Carbohydrate-Active Enzymes from Hyperthermophiles: Biochemistry and Applications
Carbohydrate-active enzymes (cazymes) are enzymatic activities involved in the hydrolysis, synthesis, recognition, and binding of carbohydrates, thereby contributing to the metabolism and mobilization of sugars and glycoconjugates (glycoproteins and glycolipids). Cazymes play a central role in glycobiology, a relatively new discipline, which aims to recognize the confluence of the traditional disciplines of carbohydrate chemistry and biochemistry with modern understanding of the cellular and molecular biology of glycans (Varki et al. 2008). In the centrality of glycobiology in life science, the study of cazymes is fundamental for the understanding of the biochemical and enzymatic processes at the basis of glycan mobilization, which regulate important cellular events including energy metabolism, intracellular regulatory switch, protein trafficking, signal transduction, cell–cell interaction, host–parasite interaction, and many others.
The study of cazymes is also recognized...
KeywordsGlycoside Hydrolase Bovine Spongiform Encephalopathy Family GH13 CAZy Database Trehalose Synthesis
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