Table 3 Frequent antibodies in patients with systemic scleroderma (SSc)
From: Scleroderma
Autoantibodies | Associated organ involvement | Frequency % | |
|---|---|---|---|
SSc-typical autoantibodies | Anti-centromere | Pulmonary arterial hypertension | 40 |
Anti-Scl-70 (topoisomerase-1) | Digital ulcerations, pulmonary fibrosis | 30 | |
Anti-RNA polymerase III | Renal crisis, extensive skin fibrosis, paraneoplasia | 5 | |
Anti-PM-Scl | Myositis, pulmonary involvement | 5 | |
U1-RNP | Joint involvement | 5 | |
SSc-associated Autoantibodies | Ro, La | Parotid gland (Sjögren’s syndrome) | 20–25 |
CCP | Arthritis | 5 | |
RF | Arthritis | 5 | |
M-2 | Liver (primary biliary cirrhosis) | 4 | |