Zusammenfassung
Epidemiologischer Hauptrisikofaktor eines Demenzsyndroms ist das Alter. Die Ursachen der Demenzen sind sehr heterogen und reichen von vermeidbaren zu behandelbaren Erkrankungen bis zu neurodegenerativen Demenzformen, deren Manifestation durch eine Reihe behandelbarer Faktoren zu beeinflussen ist. Die wichtigste Demenzursache in der westlichen Welt ist die sog. Alzheimer-Krankheit mit charakteristischen Eiweißablagerungen im Gehirn (Plaques und Neurofibrillen). Die mit Abstand häufigste Demenzform ist die gemischte Demenz mit einer Kombination von Alzheimer- und vaskulären Hirnveränderungen. Für Prävention und Gesundheitsförderung kommt den folgenden bekannten Risikofaktoren in der Europäischen Union eine hohe Bedeutung zu: Depression, Bewegungsmangel, Adipositas, Hypertonus, Diabetes mellitus und Nikotinismus. Daneben gibt es eine Reihe von Faktoren, deren Bedeutung erst in den letzten Jahren untersucht wurde, z. B. Lebensereignisse, Beruf, Umweltverschmutzung, Wahrnehmungsstörungen, Einsamkeit, Zahnhygiene, Schlaf u. v. a. Häufig übersehen werden potenzielle Demenzursachen, die im Vorfeld zu behandeln oder ganz zu vermeiden sind wie Infektionen und Schädel-Hirn-Verletzungen.
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Notes
- 1.
Wegen der besseren Lesbarkeit werden zur Beschreibung eines veränderten Risikos im Folgenden nicht die „Relativen Risiken (RR)“ oder „Risikoquotienten (Hazard Ratios, HR)“, sondern vereinfacht die Abweichung in Prozent (%) gegenüber Kontrollgruppen angegeben, die den Risikofaktor nicht aufweisen.
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Förstl, H., Förstl, S. (2020). Demenzerkrankungen – Prävalenz, Bedeutung und Implikationen für die Prävention und Gesundheitsförderung. In: Tiemann, M., Mohokum, M. (eds) Prävention und Gesundheitsförderung. Springer Reference Pflege – Therapie – Gesundheit . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-55793-8_58-1
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