Skip to main content
SpringerLink
Log in

Hyperprolaktinämie

  • Living reference work entry
  • First Online:
Reproduktionsmedizin

Part of the book series: Springer Reference Medizin ((SRM))

  • 208 Accesses

Zusammenfassung

Prolaktin bereitet häufig Probleme bei der Interpretation und ist daher ein möglicher Ausgangspunkt fragwürdiger diagnostischer und therapeutischer Entscheidungen. Unsicherheit besteht oft hinsichtlich der Notwendigkeit einer bildgebenden Diagnostik, dem Follow-up auffälliger Werte, dem Verhalten bei Zyklusstörungen, bei Kinderwunsch, in der Schwangerschaft und Stillzeit. Das Kapitel beschäftigt sich mit den genannten Punkten, fasst das praxisrelevante Wissen zusammen und erarbeitet mögliche Flussschemata für das tägliche Handeln in der Routine.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Literatur

  • Arden KC, Boutin JM, Djiane J, Kelly PA, Cavenee WK (1990) The receptors for prolactin and growth hormone are localized in the same region of human chromosome 5. Cytogenet Cell Genet 53:161–165

    Article  CAS  PubMed  Google Scholar 

  • Astwood EB (1941) The regulation of corpus luteum function by hypophysial luteotrophin. Endocrinology 29:309–319

    Article  Google Scholar 

  • Auriemma RS, Pivonello R, Perone Y, Grasso LF, Ferreri L, Simeoli C, Iacuaniello D, Gasperi M, Colao A (2013a) Safety of long-term treatment with cabergoline on cardiac valve disease in patients with prolactinomas. Eur J Endocrinol 169:359–366

    Article  CAS  PubMed  Google Scholar 

  • Auriemma RS, Perone Y, Di Sarno A, Grasso LF, Guerra E, Gasperi M, Pivonello R, Colao A (2013b) Results of a single-center observational 10-year survey study on recurrence of hyperprolactinemia after pregnancy and lactation. J Clin Endocrinol Metab 98:372–379

    Article  CAS  PubMed  Google Scholar 

  • Barlier A, Jaquet P (2006) Quinagolide – a valuable treatment option for hyperprolactinaemia. Eur J Endocrinol 154:187–195

    Article  CAS  PubMed  Google Scholar 

  • Ben-Jonathan N, Mershon JL, Allen DL, Steinmetz RW (1996) Extrapituitary prolactin: distribution, regulation and clinical aspects. Endocr Rev 17:639–669

    PubMed  CAS  Google Scholar 

  • Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev 19:225–268

    Article  CAS  PubMed  Google Scholar 

  • Clemens JA, Roush ME, Fuller RW (1978) Evidence that serotonin neurons stimulate secretion of prolactin releasing factor. Life Sci 22:2209–2213

    Article  CAS  PubMed  Google Scholar 

  • Colao A, Di Sarno A, Cappabianca P, Di Somma C, Pivonello R, Lombardi G (2003) Withdrawal of long-term cabergoline therapy for tumoral and nontumoral hyperprolactinemia. N Engl J Med 349:2023–2033

    Article  CAS  PubMed  Google Scholar 

  • Dekkers OM, Lagro J, Burman P, Jørgensen JO, Romijn JA, Pereira AM (2010) Recurrence of hyperprolactinemia after withdrawal of dopamine agonists: systematic review and meta-analysis. J Clin Endocrinol Metab 95:43–51

    Article  CAS  PubMed  Google Scholar 

  • Goffin V, Shiverick KT, Kelly PA, Martial JA (1996) Sequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen and related proteins in mammals. Endocr Rev 17:385–410

    PubMed  CAS  Google Scholar 

  • Goffin V, Binart N, Touraine P, Kelly PA (2002) Prolactin. The new biology of an old hormone. Annu Rev Physiol 64:47–67

    Article  CAS  PubMed  Google Scholar 

  • Golander A, Hurley T, Barret J, Hizi A, Handwerger S (1978) Prolactin synthesis by human chorion-decidual tissue: a possible source of prolactin in the amniotic fluid. Science 202:311–313

    Article  CAS  PubMed  Google Scholar 

  • Jacobs LS, Snyder PJ, Wilbur JF, Utiger RD, Daughaday WH (1971) Increased serum prolactin after administration of synthetic thyrotropin releasing hormone (TRH) in man. J Clin Endocrinol Metab 33:996–998

    Article  CAS  PubMed  Google Scholar 

  • Maslar IA, Riddick DH (1979) Prolactin production by human endometrium during the normal menstrual cycle. Am J Obstet Gynecol 135:751–754

    Article  CAS  PubMed  Google Scholar 

  • McNatty KP, Sawers RS, McNeilly AS (1974) A possible role for prolactin in control of steroid secretion by the Graafian follicle. Nature 250:653–655

    Article  CAS  PubMed  Google Scholar 

  • Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA, Endocrine Society (2011) Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:273–288

    Article  CAS  PubMed  Google Scholar 

  • Molitch ME, Russell EJ (1990) The pituitary „incidentaloma“. Ann Intern Med 112:925–931

    Article  CAS  PubMed  Google Scholar 

  • Naliato EC, Violante AH, Caldas D, Farias ML, Bussade I, Lamounier Filho A, Loureiro CR, Fontes R, Schrank Y, Loures T, Colao A (2008) Bone density in women with prolactinoma treated with dopamine agonists. Pituitary 11:21–28

    Article  CAS  PubMed  Google Scholar 

  • Nawroth F (2005) Hyperprolactinemia and the regular menstrual cycle in asymptomatic women – should it be treated during therapy of infertility? Reprod Biomed Online 11:581–588

    Article  CAS  PubMed  Google Scholar 

  • Nawroth F, Ludwig M (2007) Persistierende Hyperprolaktinämie ohne Zyklusstörungen. Frauenarzt 48:454–459

    Google Scholar 

  • Ono M, Miki N, Amano K, Kawamata T, Seki T, Makino R, Takano K, Izumi S, Okada Y, Hori T (2010) Individualized high-dose cabergoline therapy for hyperprolactinemic infertility in women with micro- and macroprolactinomas. J Clin Endocrinol Metab 95:2672–2679

    Article  CAS  PubMed  Google Scholar 

  • Phelps JY, Bugg EM, Shamblott MJ, Vlahos NP, Whelan J, Zacur HA (2003) Prolactin gene expression in human ovarian follicular cells. Fertil Steril 79:182–185

    Article  PubMed  Google Scholar 

  • Posner BI, Kelly PA, Shiu RP, Friesen HG (1974) Studies of insulin, growth hormone and prolactin binding: tissue distribution, species variation and characterization. Endocrinology 95:521–531

    Article  CAS  PubMed  Google Scholar 

  • Raber W, Gessl A, Nowotny P, Vierhapper H (2003) Hyperprolactinaemia in hypothyroidism: clinical significance and impact of TSH normalization. Clin Endocrinol 58:185–191

    Article  Google Scholar 

  • Riddle O, Bates RW, Dykshorn SW (1933) The preparation, identification and assay of prolactin – a hormone of the anterior pituitary. Am J Phys 105:191–216

    CAS  Google Scholar 

  • Schade R, Andersohn F, Suissa S, Haverkamp W, Garbe E (2007) Dopamine agonists and the risk of cardiac-valve regurgitation. N Engl J Med 356:29–38

    Article  CAS  PubMed  Google Scholar 

  • Schlechte J, Dolan K, Sherman B, Chapler F, Luciano A (1989) The natural history of untreated hyperprolactinemia: a prospective analysis. J Clin Endocrinol Metab 68:412–418

    Article  CAS  PubMed  Google Scholar 

  • Sinha YN (1995) Structural variants of prolactin: occurrence and physiological significance. Endocr Rev 16:354–396

    Article  CAS  PubMed  Google Scholar 

  • Tan T, Cabrita IZ, Hensman D, Grogono J, Dhillo WS, Baynes KC, Eliahoo J, Meeran K, Robinson S, Nihoyannopoulos P, Martin NM (2010) Assessment of cardiac valve dysfunction in patients receiving cabergoline treatment for hyperprolactinaemia. Clin Endocrinol 73:369–374

    Article  CAS  Google Scholar 

  • Vartej P, Poiana C, Vartej I (2001) Effects of hyperprolactinemia on osteoporotic fracture risk in premenopausal women. Gynecol Endocrinol 15:43–47

    Article  CAS  PubMed  Google Scholar 

  • Velasquez EV, Trigo RV, Creus S, Campo S, Croxatto HB (2006a) Pituitary-ovarian axis during lactational amenorrhoea. I. Longitudinal assessment of follicular growth, gonadotrophins, sex steroids and inhibin levels before and after recovery of menstrual cyclicity. Hum Reprod 21:909–915

    Article  CAS  PubMed  Google Scholar 

  • Velasquez EV, Creus S, Trigo RV, Cigorraga SB, Pellizzari EH, Croxatto HB, Campo S (2006b) Pituitary-ovarian axis during lactational amenorrhoea. II. Longitudinal assessment of serum FSH polymorphism before and after recovery of menstrual cycles. Hum Reprod 21:916–923

    Article  CAS  PubMed  Google Scholar 

  • Verhelst J, Abs R (2003) Hyperprolactinemia: pathophysiology and management. Treat Endocrinol 2:23–32

    Article  PubMed  Google Scholar 

  • Yazigi RA, Quintero CH, Salameh WA (1997) Prolactin disorders. Fertil Steril 67:215–225

    Article  CAS  PubMed  Google Scholar 

  • Zanettini R, Antonini A, Gatto G, Gentile R, Tesei S, Pezzoli G (2007) Valvular heart disease and the use of dopamine agonists for Parkinson’s disease. N Engl J Med 356:39–46

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Facharzt-Zentrum für Kinderwunsch, Pränatale Medizin, Endokrinologie und Osteologie, amedes MVZ Hamburg, Hamburg, Deutschland

    Frank Nawroth

Authors
  1. Frank Nawroth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Frank Nawroth .

Editor information

Editors and Affiliations

  1. Facharzt-Zentrum für Kinderwunsch, Pränatale Medizin, Endokrinologie und Osteologie Hamburg GmbH, amedes experts, Hamburg, Germany

    Klaus Diedrich

  2. SYNLAB Holding Deutschland GmbH, Augsburg, Hamburg, Germany

    Michael Ludwig

  3. Sektion für gynäkologische Endokrinologie und Reproduktionsmedizin, UNIVERSITÄTSKLINIKUM Schleswig-Holstein – Campus Lübeck, Lübeck, Schleswig-Holstein, Germany

    Georg Griesinger

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Nawroth, F. (2018). Hyperprolaktinämie. In: Diedrich, K., Ludwig, M., Griesinger, G. (eds) Reproduktionsmedizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-55601-6_5-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-55601-6_5-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-55601-6

  • Online ISBN: 978-3-662-55601-6

  • eBook Packages: Springer Referenz Medizin

Publish with us

Policies and ethics

Search

Navigation