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Endokrine Kontrolle der Ovarfunktion

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Reproduktionsmedizin

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Zusammenfassung

In diesem Kapitel sollen die strukturellen und endokrinologischen Zusammenhänge der Ovarfunktion und deren Regulation erläutert werden. Das Wissen um diese Vorgänge ist für das Verstehen von pathophysiologischen Veränderungen der Endokrinologie sowie für das Ableiten einer kausalen Therapie essenziell.

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Literatur

  • Adams TE, Norman RL, Spies HG (1981) Gonadotropin-releasing hormone receptor binding and pituitary responsiveness in estradiol-primed monkeys. Science 213(4514):1388–1390

    Article  CAS  PubMed  Google Scholar 

  • Andersen CY, Byskov AG (2006) Estradiol and regulation of anti-Müllerian hormone, inhibin-A, and inhibin-B secretion: analysis of small antral and preovulatory human follicles’ fluid. J Clin Endocrinol Metab 91(10):4064–4069

    Article  CAS  PubMed  Google Scholar 

  • Baerwald AR, Adams GP, Pierson RA (2003) A new model for ovarian follicular development during the human menstrual cycle. Fertil Steril 80(1):116–122

    Article  PubMed  Google Scholar 

  • Berg MH van den, van Dulmen-den Broeder E, Overbeek A, Twisk JW, Schats R, van Leeuwen FE, Kaspers GJ, Lambalk CB (2010) Comparison of ovarian function markers in users of hormonal contraceptives during the hormone-free interval and subsequent natural early follicular phases. Hum Reprod 25:1520–1527

    Google Scholar 

  • Brougham MF, Crofton PM, Johnson EJ, Evans N, Anderson RA, Wallace WH (2012) Anti-Müllerian hormone is a marker of gonadotoxicity in pre- and postpubertal girls treated for cancer: a prospective study. J Clin Endocrinol Metab 97(6):2059–2067. https://doi.org/10.1210/jc.2011-3180. Epub 2012 Apr 3

    Article  CAS  Google Scholar 

  • Brown GM (1992) Day-night rhythm disturbance, pineal function and human disease. Horm Res 37(3):105–111. Review. PubMed PMID: 1427635

    Article  PubMed  Google Scholar 

  • Bulling A, Berg FD, Berg U, Duffy DM, Stouffer RL, Ojeda SR, Gratzl M, Mayerhofer A (2000) Identification of an ovarian voltage-activated Na+-channel type: hints to involvement in luteolysis. Mol Endocrinol 14(7):1064–1074

    Article  CAS  PubMed  Google Scholar 

  • Burger HG (1993) Evidence for a negative feedback role of inhibin in follicle stimulating hormone regulation in women. Hum Reprod 8(2):129–132

    Article  CAS  PubMed  Google Scholar 

  • Cagnacci A, Soldani R, Yen SS (1995) Exogenous melatonin enhances luteinizing hormone levels of women in the follicular but not in the luteal menstrual phase. Fertil Steril 63(5):996–999. PubMed PMID: 7720945

    Google Scholar 

  • Carmel PD, Araki S, Ferin M (1976) Prolonged stalk portal blood collection in rhesus monkeys: pulsatile release of gonadotrophin releasing hormone (GnRH). Endocrinology 99:243

    Article  CAS  PubMed  Google Scholar 

  • Channing CP, Schaerf FW, Anderson LD, Tsafriri A (1980) Ovarian follicular and luteal physiology. Int Rev Physiol 22:117–201

    CAS  PubMed  Google Scholar 

  • Christian CA, Moenter SM (2010) The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges. Endocr Rev 31(4):544–577. [Epub 2010 Mar 17]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Clark IJ (1995) The preovulatory LH surge – a case of a neuroendocrine switch. Trends Endocrinol 6:241

    Article  Google Scholar 

  • Craig J, Orisaka M, Wang H, Orisaka S, Thompson W, Zhu C, Kotsuji F, Tsang BK (2007) Gonadotropin and intra-ovarian signals regulating follicle development and atresia: the delicate balance between life and death. Front Biosci 1(12):3628–3639

    Article  Google Scholar 

  • Dewailly D, Robin G, Peigne M, Decanter C, Pigny P, Catteau-Jonard S (2016) Interactions between androgens, FSH, anti-Müllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary. Hum Reprod Update 22(6):709–724. Epub 2016 Aug 27. Review. PubMed PMID: 27566840

    Article  CAS  PubMed  Google Scholar 

  • Dodé C, Hardelin JP (2004) Kallmann syndrome: fibroblast growth factor signaling insufficiency? J Mol Med (Berl) 82(11):725–734

    Article  CAS  Google Scholar 

  • Döderlein G (1985) Aufbau des weiblichen Genitaltraktes. In: Krebs D, Schwalm H, Wulf KH, Schmidt-Matthiessen H (Hrsg) Reproduktion, Störungen in der Frühgravidität, Bd 3 Klinik der Frauenheilkunde und Geburtshilfe. Urban & Schwarzenberg, München

    Google Scholar 

  • Donadeu FX, Esteves CL, Doyle LK, Walker CA, Schauer SN, Diaz CA (2011) Phospholipase Cβ3 mediates LH-induced granulosa cell differentiation. Endocrinology 152(7):2857–2869

    Article  CAS  PubMed  Google Scholar 

  • Duffy DM (2011) Prostaglandin dehydrogenase (PGDH) in granulosa cells of primate periovulatory follicles is regulated by the ovulatory gonadotropin surge via multiple G proteins. Mol Cell Endocrinol 333(2):119–126. [Epub 2010 Dec 16]

    Article  CAS  PubMed  Google Scholar 

  • Duffy DM, Stewart DR, Stouffer RL (1999) Titrating luteinizing hormone replacement to sustain the structure and function of the corpus luteum after gonadotropin-releasing hormone antagonist treatment in rhesus monkeys. J Clin Endocrinol Metab 84(1):342–349

    CAS  PubMed  Google Scholar 

  • Durlinger AL, Gruijters MJ, Kramer P, Karels B, Kumar TR, Matzuk MM, Rose UM, de Jong FH, Uilenbroek JT, Grootegoed JA et al (2001) Anti-Mullerian hormone attenuates the effects of FSH on follicle development in the mouse ovary. Endocrinology 142:4891–4899

    Article  CAS  PubMed  Google Scholar 

  • Faddy M, Gosden R (2007) Numbers of ovarian follicles and testing germ line renewal in the postnatal ovary: facts and fallacies. Cell Cycle 6(15):1951–1952

    Article  CAS  PubMed  Google Scholar 

  • García-Galiano D, Pinilla L, Tena-Sempere M (2012) Sex steroids and the control of the kiss1 system: developmental roles and major regulatory actions. J Neuroendocrinol 24(1):22–33

    Article  PubMed  CAS  Google Scholar 

  • Graaf R de (1672/1966) JAMA 195(4):324. https://doi.org/10.1001/jama.1966.03100040130050

    Article  Google Scholar 

  • Hagen CP, Vestergaard S, Juul A, Skakkebaek NE, Andersson AM, Main KM, Hjollund NH, Ernst E, Bonde JP, Anderson RA et al (2012) Low concentration of circulating anti-Mu ̈llerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study. Fertil Steril 98:1602–1608

    Article  CAS  PubMed  Google Scholar 

  • Himelstein-Braw R, Byskov AG, Peters H, Faber M (1976) Follicular atresia in the infant human ovary. J Reprod Fertil 46(1):55–59

    Article  CAS  PubMed  Google Scholar 

  • Hsueh AJ, Kawamura K, Cheng Y, Fauser BC (2015) Intraovarien control of early folliculogenesis. Endocr Rev 36:1–24

    Article  CAS  PubMed  Google Scholar 

  • Hwang JJ, Lin SW, Teng CH, Ke FC, Lee MT (1996) Relaxin modulates the ovulatory process and increases secretion of different gelatinases from granulosa and theca-interstitial cells in rats. Biol Reprod 55(6):1276–1283

    Article  CAS  PubMed  Google Scholar 

  • Ijzendoorn MH van, Huffmeijer R, Alink LR, Bakermans-Kranenburg MJ, Tops M (2011) the impact of oxytocin administration on charitable donating is moderated byexperiences of parental love-withdrawal Front Psychol 2:258

    Google Scholar 

  • Jayasena CN, Nijher GM, Abbara A, Murphy KG, Lim A, Patel D, Mehta A, Todd C, Donaldson M, Trew GH, Ghatei MA, Bloom SR, Dhillo WS (2010) Twice-weekly administration of kisspeptin-54 for 8 weeks stimulates release of reproductive hormones in women with hypothalamic amenorrhea. Clin Pharmacol Ther 88(6):840–847

    Article  CAS  PubMed  Google Scholar 

  • Kallio S, Puurunen J, Ruokonen A, Vaskivuo T, Piltonen T, Tapanainen JS (2013) Antimullerian hormone levels decrease in women using combined contraception independently of administration route. Fertil Steril 99:1305–1310

    Article  CAS  PubMed  Google Scholar 

  • Kalra SP (1993) Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone releasing hormone discharge. Endocr Rev 14(5):507–538

    CAS  PubMed  Google Scholar 

  • Karsch FJ, Sutton GP (1976) An intra-ovarian site for the luteolytic action of estrogen in the rhesus monkey. Endocrinology 98(3):553–561

    Article  CAS  PubMed  Google Scholar 

  • Kelsey TW, Wright P, Nelson SM, Anderson RA, Wallace WH (2011) A validated model of serum anti-Mu ̈llerian hormone from conception to menopause. PloS one 6:e22024

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Khan-Dawood FS, Yang J, Anwer K, Dawood MY (1995) Bioactive oxytocin in human and baboon corpora lutea. J Endocrinol 47(3):525–532

    Article  Google Scholar 

  • Knight PG, Glister C (2006) TGF-beta superfamily members and ovarian follicle development. Reproduction 132(2):191–206

    Article  CAS  PubMed  Google Scholar 

  • Ko C, Gieske MC, Al-Alem L, Hahn Y, Su W, Gong MC, Iglarz M, Koo Y (2006) Endothelin-2 in ovarian follicle rupture. Endocrinology 147(4):1770–1779

    Article  CAS  PubMed  Google Scholar 

  • Kol S, Adashi EY (1995) Intraovarian factors regulating ovarian function. Curr Opin Obstet Gynecol 7(3):209–213

    Article  CAS  PubMed  Google Scholar 

  • Koob GF, Le Brun C, Martinez JL Jr et al (1985) Use of arginine vasopressin antagonists in elucidating the mechanism of action for behavioral effects of arginine vasopressin. In: Schrier RW (Hrsg) Vasopressin. Raven, New York

    Google Scholar 

  • Loutradis D, Patsoula E, Minas V, Koussidis GA, Antsaklis A, Michalas S, Makrigiannakis A (2006) FSH receptor gene polymorphisms have a role for different ovarian response to stimulation in patients entering IVF/ICSI-ET programs. J Assist Reprod Genet 23(4):177–184

    Article  PubMed  PubMed Central  Google Scholar 

  • Ludwig M (2009) Regulation der Ovarfunktion, Kap. 5. In: Leidenberger F, Strowitzki T, Ortmann O (Hrsg) Klinische Endokrinologie für Frauenärzte, 4. Aufl. Springer, Berlin/Heidelberg/New York

    Google Scholar 

  • Ludwig M et al (2007) Sexuelle Differenzierung und Entwichlung. In: Diedrich K, Holzgreve W, Jonat W, Weiss S-MA (Hrsg) Gynäkologie und Geburtshilfe, 2. Aufl. Springer, Berlin/Heidelberg/New York

    Google Scholar 

  • Markosyan N, Duffy DM (2009) Prostaglandin E2 acts via multiple receptors to regulate plasminogen-dependent proteolysis in the primate periovulatory follicle. Endocrinology 150(1):435–444

    Article  CAS  PubMed  Google Scholar 

  • Marut EL, Williams RF, Cowan BD, Lynch A, Lerner SP, Hodgen GD (1981) Pulsatile pituitary gonadotropin secretion during maturation of the dominant follicle in monkeys: estrogen positive feedback enhances the biological activity of LH. Endocrinology 109(6):2270–2272

    Article  CAS  PubMed  Google Scholar 

  • Maseelall PB, Seungdamrong A, Weiss G, Wojtczuk AS, Donnelly R, Stouffer RL, Goldsmith LT (2009) Expression of LGR7 in the primate corpus luteum implicates the corpus luteum as a relaxin target organ. Ann N Y Acad Sci 1160:147–151

    Article  CAS  PubMed  Google Scholar 

  • Matsuda-Minehata F, Inoue N, Goto Y, Manabe N (2006) The regulation of ovarian granulosa cell death by pro- and anti-apoptotic molecules. J Reprod Dev 52(6):695–705

    Article  CAS  PubMed  Google Scholar 

  • McGee EA, Hsueh AJ (2000) Initial and cyclic recruitment of ovarian follicles. Endocr Rev 21(2):200–214

    CAS  PubMed  Google Scholar 

  • Mukhopadhyay AK, Leidenberger FA, Lichtenberg V (1979) A comparison of bioactivity and immunoactivity of luteinizing hormone stored in and released in vitro from pituitary glands of rats under various gonadal states. Endocrinology 104(4):925–931

    Article  CAS  PubMed  Google Scholar 

  • Murdoch WJ, Murphy CJ, Van Kirk EA, Shen Y (2010) Mechanisms and pathobiology of ovulation. Soc Reprod Fertil Suppl 67:189–201

    CAS  PubMed  Google Scholar 

  • Nakhuda GS, Douglas NC, Thornton MH, Guarnaccia MM, Lobo R, Sauer MV (2011) Anti-Müllerian hormone testing is useful for individualization of stimulation Protocols in oocyte donors. Reprod BioMed Online 22(1):88–93

    Article  Google Scholar 

  • Neill JD, Patton JM, Dailey RA, Tsou RC, Tindall GT (1977) Luteinizing hormone releasing hormone (LHRH) in pituitary stalk blood of rhesus monkeys: relationship to level of LH release. Endocrinology 101(2):430–434

    Article  CAS  PubMed  Google Scholar 

  • Nelson SM, Stewart F, Fleming R, Freeman DJ (2010) Longitudinal assessment of antimullerian hormone during pregnancy-relationship with maternal adiposity, insulin, and adiponectin. Fertil Steril 93:1356–1358

    Article  CAS  PubMed  Google Scholar 

  • Norman RL, Gliessman P, Lindstrom SA, Hill J, Spies HG (1982) Reinitiation of ovulatory cycles in pituitary stalk-sectioned rhesus monkeys: evidence for a specific hypothalamic message for the preovulatory release of luteinizing hormone. Endocrinology 111(6):1874–1882

    Article  CAS  PubMed  Google Scholar 

  • O’Brien MJ, Pendola JK, Eppig JJ (2003) A revised protocol for in vitro development of mouse oocytes from primordial follicles dramatically improves their developmental competence. Biol Reprod 68(5):1682–1686. [Epub 2002 Dec 11]

    Article  PubMed  CAS  Google Scholar 

  • Ohnishi J, Ohnishi E, Shibuya H, Takahashi T (2005) Functions for proteinases in the ovulatory process. Biochim Biophys Acta 1751(1):95–109

    Article  CAS  PubMed  Google Scholar 

  • Oktem O, Oktay K (2008) The ovary: anatomy and function throughout human life. Ann N Y Acad Sci 1127:1–9

    Article  CAS  PubMed  Google Scholar 

  • Oktem O, Urman B (2010) Understanding follicle growth in vivo. Hum Reprod 25(12):2944–2954

    Article  PubMed  Google Scholar 

  • Pellatt L, Rice S, Dilaver N, Heshri A, Galea R, Brincat M, Brown K, Simpson ER, Mason HD (2011) Anti-Müllerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells. Fertil Steril 96(5):1246–1251.e1

    Article  CAS  PubMed  Google Scholar 

  • Pinilla L, Seoane LM, Gonzalez L, Carro E, Aguilar E, Casanueva FF, Dieguez C (1999) Regulation of serum leptin levels by gonadal function in rats. Eur J Endocrinol 140(5):468–473

    Article  CAS  PubMed  Google Scholar 

  • Plaza S, Chanut-Delalande H, Fernandes I, Wassarman PM, Payre F (2010) From A to Z: apical structures and zona pellucida-domain proteins. Trends Cell Biol 20(9):524–532

    Article  CAS  PubMed  Google Scholar 

  • Raciborski (1875) Periodische Fruchtbarkeit und Unfruchtbarkeit [zit. in Albrecht A (1936)]. Arch Gynaekol Obst 161(1):23–51

    Google Scholar 

  • Robertson DM, Klein R, de Vos FL, McLachlan RI, Wettenhall RE, Hearn MT, Burger HG, de Kretser DM (1987) The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin. Biochem Biophys Res Commun 149(2):744–749

    Article  CAS  PubMed  Google Scholar 

  • Rossmanith WG (1991) Zirkadiane und ultradiane Rhythmen in der Gonadotropinsekratioin: Regulationi durch ovarielle Steroide. Geburtsh Frauenheilkd 51:585

    Article  CAS  Google Scholar 

  • Rossmanith WG (1993) Ultradian and circadian patterns in luteinizing hormone secretion during reproductive life in women. Hum Reprod. 8(Suppl 2):77–83. Review

    Article  CAS  PubMed  Google Scholar 

  • Rossmanith WG, Wirth U (1993) Einflüsse des Schlafes auf die Gonadotropinsekretion. Geburtsh Frauenheilkd 53:735

    Article  CAS  Google Scholar 

  • Sahu A, Crowley WR, Kalra SP (1994) Hypothalamic neuropeptide-Y gene expression increases before the onset of the ovarian steroid-induced luteinizing hormone surge. Endocrinology 134(3):1018–1022

    Article  CAS  PubMed  Google Scholar 

  • Shirasuna K, Shimizu T, Hayashi KG, Nagai K, Matsui M, Miyamoto A (2007) Positive association, in local release, of luteal oxytocin with endothelin 1 and prostaglandin F2alpha during spontaneous luteolysis in the cow: a possible intermediatory role for luteolytic cascade within the corpus luteum. Biol Reprod 76(6):965–970

    Article  CAS  PubMed  Google Scholar 

  • Shoham Z, Schacter M, Loumaye E, Weissman A, MacNamee M, Insler V (1995) The luteinizing hormone surge--the final stage in ovulation induction: modern aspects of ovulation triggering. Fertil Steril 64(2):237–251

    Article  CAS  PubMed  Google Scholar 

  • Somunkiran A, Yavuz T, Yucel O, Ozdemir I (2007) Anti-Müllerian hormone levels during hormonal contraception in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 134(2):196–201

    Article  CAS  PubMed  Google Scholar 

  • Speroff L, Glass RH, Kase NG (1984) Clinical gynecologic endocrinology and infertility, 3. Aufl. Williams & Wilkins, Baltimore/London

    Google Scholar 

  • Stouffer RL (1996) Corpus luteum formation and demise. In: Adashi EY, Rock JA, Rosenwaks Z (Hrsg) Reproductive endocrinology, surgery, and technology. Lippincott-Raven, New York, S 263–263

    Google Scholar 

  • Strowitzki T (2009) Entwicklung und Funktion der weiblichen Fortpflanzungsorgane. In: Leidenberger F, Strowitzki T, Ortmann O (Hrsg) Klinische Endokrinologie für Frauenärzte, 4. Aufl. Springer, Berlin/Heidelberg/New York

    Google Scholar 

  • Tolikas A, Tsakos E, Gerou S, Prapas Y, Loufopoulos A (2011) Anti-Mullerian hormone (AMH) levels in serum and follicular fluid as predictors of ovarian response in stimulated (IVF and ICSI) cycles. Hum Fertil (Camb) 14(4):246–253

    Article  CAS  Google Scholar 

  • Vaiarelli A, Venturella R, Vizziello D, Bulletti F, Ubaldi FM (2017) Dual ovarian stimulation and random start in assisted reproductive technologies: from ovarian biology to clinical application. Curr Opin Obstet Gynecol 29(3):153–159

    Article  PubMed  Google Scholar 

  • Walters KA, Allan CM, Handelsman DJ (2008) Androgen actions and the ovary. Biol Reprod 78(3):380–389. [Epub 2007 Nov 14] Review

    Article  CAS  PubMed  Google Scholar 

  • Wildt L, Marshall G, Knobil E (1980) Experimental induction of puberty in the infantile female rhesus monkey. Science 207(4437):1373–1375

    Article  CAS  PubMed  Google Scholar 

  • Wilhelm D, Koopman P (2006) The makings of maleness: towards an integrated view of male sexual development. Nat Rev Genet 7(8):620–631

    Article  CAS  PubMed  Google Scholar 

  • Wunder DM, Bersinger NA, Yared M, Kretschmer R, Birkhäuser MH (2008) Statistically significant changes of antimüllerian hormone and inhibin levels during the physiologic menstrual cycle in reproductive age women. Fertil Steril 89(4):927–933

    Article  CAS  PubMed  Google Scholar 

  • Yates AP, Rustamov O, Roberts SA, Lim HY, Pemberton PW, Smith A, Nardo LG (2011) Anti-Mullerian hormone-tailored stimulation protocols improve outcomes whilst reducing adverse effects and costs of IVF. Hum Reprod 26(9):2353–2362

    Article  CAS  PubMed  Google Scholar 

  • Ying SY (1988) Inhibins, activins, and follistatins: gonadal proteins modulating the secretion of follicle-stimulating hormone. Endocr Rev 9:267

    Article  CAS  PubMed  Google Scholar 

  • Zeleznik AJ (1998) In vivo responses of the primate corpus luteum to luteinizing hormone and chorionic gonadotropin. Proc Natl Acad Sci U S A 95(18):11002–11007

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Gynaekologicum Hamburg, Kinderwunschzentrum Altonaer Strasse, Hamburg, Deutschland

    Tim Cordes

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  1. Tim Cordes
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Correspondence to Tim Cordes .

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  1. Facharzt-Zentrum für Kinderwunsch, Pränatale Medizin, Endokrinologie und Osteologie Hamburg GmbH, amedes experts, Hamburg, Germany

    Klaus Diedrich

  2. SYNLAB Holding Deutschland GmbH, Augsburg, Hamburg, Germany

    Michael Ludwig

  3. Sektion für gynäkologische Endokrinologie und Reproduktionsmedizin, Universitätsklinikum Schleswig-Holstein – Campus Lübeck, Lübeck, Schleswig-Holstein, Germany

    Georg Griesinger

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Cordes, T. (2019). Endokrine Kontrolle der Ovarfunktion. In: Diedrich, K., Ludwig, M., Griesinger, G. (eds) Reproduktionsmedizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-55601-6_3-1

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