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Polkörper- und Präimplantationsdiagnostik

  • Living reference work entry
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Reproduktionsmedizin

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Präimplantationsdiagnostik bezeichnet die Untersuchung von Eizellen oder Embryonen vor dem Transfer in den Uterus. Generell kann unterschieden werden zwischen der Diagnose von strukturellen/numerischen Chromosomen-Fehlverteilungen (PGS) und der Diagnose von genetischen Erkrankungen oder Prädispositionen (PID). Untersuchungen der Eizelle erfolgen am 1. und 2. Polkörper und zumeist in Ländern mit gesetzlichen Einschränkungen. Untersuchungen an Embryonen werden zumeist an Trophektodermzellen der Blastozyste durchgeführt. Der Einsatz und Nutzen der PID ist unumstritten. Hingegen wird PGS in Verbindung mit Next Generation Sequencing zur Darstellung aller Chromosomen weltweit am häufigsten eingesetzt. Neuere Studien zeigen, dass die Rate an Embryonen mit Mosaik-Diagnose und die Häufigkeit von aneuploiden Embryonen von labor- als auch klinikspezifischen Einflüssen beeinflusst zu sein scheint. Daher wird der Nutzen von PGS kontrovers diskutiert.

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Authors and Affiliations

  1. ilabcomm GmbH, St. Augustin, Deutschland

    Markus Montag

  2. Klinik für Gynäkologische Endokrinologie und Reproduktionsmedizin, Medizinische Universität Innsbruck, Innsbruck, Österreich

    Bettina Toth

  3. Abt. für Gynäkologische Endokrinologie und Fertilitätsstörungen, Universitätsklinikum Heidelberg Frauenklinik, Heidelberg, Deutschland

    Thomas Strowitzki

Authors
  1. Markus Montag
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  2. Bettina Toth
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  3. Thomas Strowitzki
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Correspondence to Markus Montag .

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  1. Facharzt-Zentrum für Kinderwunsch, Pränatale Medizin, Endokrinologie und Osteologie Hamburg GmbH, amedes experts, Hamburg, Germany

    Klaus Diedrich

  2. SYNLAB Holding Deutschland GmbH, Augsburg, Hamburg, Germany

    Michael Ludwig

  3. Sektion für gynäkologische Endokrinologie und Reproduktionsmedizin, UNIVERSITÄTSKLINIKUM Schleswig-Holstein – Campus Lübeck, Lübeck, Schleswig-Holstein, Germany

    Georg Griesinger

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© 2019 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

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Montag, M., Toth, B., Strowitzki, T. (2019). Polkörper- und Präimplantationsdiagnostik. In: Diedrich, K., Ludwig, M., Griesinger, G. (eds) Reproduktionsmedizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-55601-6_28-1

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  • DOI: https://doi.org/10.1007/978-3-662-55601-6_28-1

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  • Print ISBN: 978-3-662-55601-6

  • Online ISBN: 978-3-662-55601-6

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