Skip to main content
SpringerLink
Log in

Keimzelltumoren und seltene gonadale Tumoren bei Kindern und Jugendlichen

  • Living reference work entry
  • First Online:
Uroonkologie

Part of the book series: Springer Reference Medizin ((SRM))

  • 125 Accesses

Zusammenfassung

Die gonadalen Tumoren bei Kindern und Jugendlichen umfassen eine klinisch äußerst heterogene Gruppe von Tumoren. Sie zeigen ein charakteristisches Muster der Alters- und Geschlechtsverteilung in Bezug auf die verschiedenen histologischen Entitäten. Diese altersabhängigen Unterschiede korrelieren mit einer unterschiedlichen Tumorbiologie und Prognose. Die Diagnostik umfasst die Messung der Tumormarker AFP und β-HCG, eine endokrinologische Status sowie die radiologische Schnittbilddiagnostik. Die multimodale Therapie der malignen Tumoren erfolgt risikostratifiziert innerhalb aktueller kinderonkologischer Therapieoptimierungsstudien und -register. In niedrigen Stadien kann nach kompletter Resektion auf die adjuvante Chemotherapie verzichtet werden, allerdings nur, wenn ein konsequentes Nachsorgeschema eingehalten wird. Bei fortgeschrittenen Stadien erreicht die platin-basierte Chemotherapie die Kontrolle einer metastatischen Erkrankung. Ebenso kann sie bei großen Tumoren in einem neoadjuvanten Setting dem Erreichen einer kompletten Tumorresektion dienen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Literatur

  • Ablin AR (1981) Malignant germ cell tumors in children. Front Radiat Ther Oncol 16:141–149

    Article  CAS  Google Scholar 

  • Ablin AR, Krailo MD, Ramsay NK et al (1991) Results of treatment of malignant germ cell tumors in 93 children: a report from the Childrens Cancer Study Group. J Clin Oncol 9:1782–1792

    Article  CAS  Google Scholar 

  • Bamberg M, Kortmann RD, Calaminus G et al (1999) Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89. J Clin Oncol 17:2585–2592

    Article  CAS  Google Scholar 

  • Baranzelli MC, Kramar A, Bouffet E et al (1999) Prognostic factors in children with localized malignant nonseminomatous germ cell tumors. J Clin Oncol 17:1212–1219

    Article  CAS  Google Scholar 

  • Blohm ME, Vesterling-Hörner D, Calaminus G et al (1998) Alpha 1-fetoprotein (AFP) reference values in infants up to 2 years of age. Pediatr Hematol Oncol 15:135–142

    Article  CAS  Google Scholar 

  • Calaminus G, Bamberg M, Jürgens H et al (2004) Impact of surgery, chemotherapy and irradiation on long term outcome of intracranial malignant non-germinomatous germ cell tumors: results of the German Cooperative Trial MAKEI 89. Klin Pädiatr 216:141–149

    Article  CAS  Google Scholar 

  • Cheng L, Roth LM, Zhang S et al (2011) KIT gene mutation and amplification in dysgerminoma of the ovary. Cancer 117:2096–2103

    Article  CAS  Google Scholar 

  • Cushing B, Giller R, Cullen JW et al (2004) Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study – Pediatric Oncology Group 9049 and Children’s Cancer Group 8882. J Clin Oncol 22:2691–2700

    Article  CAS  Google Scholar 

  • Ernestus K, Pietsch T, Gessler M et al (2006) Structure, use, and risks of biomaterial repositories of embryonal tumors. Klin Pädiatr 218:132–138

    Article  CAS  Google Scholar 

  • Frappaz D, Conter C (2007) Testicular neoplasms in children: lymphatic or metastatic involvement is rare. Rev Prat 57:368–369

    PubMed  Google Scholar 

  • Fritsch MK, Schneider DT, Schuster AE et al (2006) Activation of Wnt/beta-catenin signaling in distinct histologic subtypes of human germ cell tumors. Pediatr Dev Pathol 9:115–131

    Article  CAS  Google Scholar 

  • Flamant F, Schwartz L, Delons E, Caillaud JM, Hartmann O, Lemerle J (1984) Nonseminomatous malignant germ cell tumors in children: multidrug therapy in stages III and IV. Cancer 54:1687–1691

    Article  CAS  Google Scholar 

  • Fustino N, Rakheja D, Ateek CS et al (2011) Bone morphogenetic protein signalling activity distinguishes histological subsets of paediatric germ cell tumours. Int J Androl 34:e218–e233

    Article  CAS  Google Scholar 

  • Giannarini G, Dieckmann KP, Albers P et al (2010) Organ-sparing surgery for adult testicular tumours: a systematic review of the literature. Eur Urol 57:780–790

    Article  Google Scholar 

  • Göbel U, Gutjahr P, Jürgens H et al (1986) Cooperative therapy study of nontesticular germ cell tumors MAKEI 83 of the Society of Pediatric Oncology: analysis after 3 years. Klin Pädiatr 198:237–244

    Article  Google Scholar 

  • Göbel U, Bamberg M, Engert J et al (1991) Treatment of non-testicular germ cell tumors in children and adolescents with BEP and VIP: initial results of the MAKEI 89 therapy study. Klin Pädiatr 203:236–245

    Article  Google Scholar 

  • Göbel U, Calaminus G, Engert J et al (1998) Teratomas in infancy and childhood. Med Pediatr Oncol 31:8–15

    Article  Google Scholar 

  • Göbel U, Schneider DT, Calaminus G et al (2000) Germ-cell tumors in childhood and adolescence. Ann Oncol 11:263–271

    Article  Google Scholar 

  • Göbel U, Schneider DT, Calaminus G et al (2001) Multimodal treatment of malignant sacrococcygeal germ cell tumors: a prospective analysis of 66 patients of the German cooperative protocols MAKEI 83/86 and 89. J Clin Oncol 19:1943–1950

    Article  Google Scholar 

  • Göbel U, Calaminus G, Schneider DT et al (2004) Klinik, Symptomatik und Therapiestrategien bei Keimzelltumoren des Ovars. Gynäkologe 37:806–814

    Article  Google Scholar 

  • Haas RJ, Göbel U, Harms D et al (1989) Malignant testicular tumors in children. Concept of the cooperative therapy study MAHO 88 based on MAHO 82. Klin Pädiatr 201:269–274

    Article  CAS  Google Scholar 

  • Haas RJ, Schmidt P, Göbel U et al (1993) Therapy of testicular germ cell tumors. Current status of the MAHO studies. Klin Padiatr 205:225–230

    Article  CAS  Google Scholar 

  • Harms D, Jänig U (1986) Germ cell tumours of childhood. Report of 170 cases including 59 pure and partial yolk-sac tumours. Virchows Arch A Pathol Anat Histopathol 409:223–239

    Article  CAS  Google Scholar 

  • Hennes E, Zahn S, Lopes LF et al (2012) Molecular genetic analysis of bilateral ovarian germ cell tumors. Klin Pädiatr 224:359–365

    Article  CAS  Google Scholar 

  • Hersmus R, de Leeuw BH, Stoop H et al (2009) A novel SRY missense mutation affecting nuclear import in a 46,XY female patient with bilateral gonadoblastoma. Eur J Hum Genet 17:1642–1649

    Article  Google Scholar 

  • Hofmann M, Schlegel PG, Hippert F et al (2013) Testicular sex cord stromal tumors: analysis of patients from the MAKEI study. Pediatr Blood Cancer 60:1651–1655

    Article  CAS  Google Scholar 

  • Honecker F, Kersemaekers AM, Molier M et al (2004) Involvement of E-cadherin and beta-catenin in germ cell tumours and in normal male fetal germ cell development. J Pathol 204:167–174

    Article  CAS  Google Scholar 

  • Isurugi K, Aso Y, Ishida H et al (1977) Prepubertal XY gonadal dysgenesis. Pediatrics 59:569–573

    CAS  PubMed  Google Scholar 

  • Kaatsch P, Kaletsch U, Michaelis J. Annual report of the German Childhood Cancer Registry 2004. http://www.kinderkrebsregister.de. Zugegriffen am 02.05.2019

  • Looijenga LH, Verkerk AJ, Dekker MC et al (1998) Genomic imprinting in testicular germ cell tumours. APMIS 106:187–195

    Article  CAS  Google Scholar 

  • Lopes LF, Macedo CR, Pontes EM et al (2009) Cisplatin and etoposide in childhood germ cell tumor: brazilian pediatric oncology society protocol GCT-91. J Clin Oncol 27:1297–1303

    Article  CAS  Google Scholar 

  • Mann JR, Raafat F, Robinson K et al (1998) UKCCSG’s germ cell tumour (GCT) studies: improving outcome for children with malignant extracranial non-gonadal tumours – carboplatin, etoposide, and bleomycin are effective and less toxic than previous regimens Med Pediatr Oncol 30:217–227

    Article  CAS  Google Scholar 

  • Mann JR, Raafat F, Robinson K et al (2000) The United Kingdom Children’s Cancer Study Group’s second germ cell tumor study: carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. J Clin Oncol 18:3809–3818

    Article  CAS  Google Scholar 

  • Murray MJ, Saini HK, van Dongen S et al (2010) The two most common histological subtypes of malignant germ cell tumour are distinguished by global microRNA profiles, associated with differential transcription factor expression. Mol Cancer 9:290

    Article  Google Scholar 

  • Murray MJ, Halsall DJ, Hook CE et al (2011) Identification of microRNAs From the miR-371~373 and miR-302 clusters as potential serum biomarkers of malignant germ cell tumors. Am J Clin Pathol 135:119–125

    Article  CAS  Google Scholar 

  • Neumann JC, Lillard K, Damoulis V et al (2011) Zebrafish models of germ cell tumor. Methods Cell Biol 105:3–24

    PubMed  PubMed Central  Google Scholar 

  • Nichols CR, Heerema NA, Palmer C et al (1987) Klinefelter’s syndrome associated with mediastinal germ cell neoplasms. J Clin Oncol 5:1290–1294

    Article  CAS  Google Scholar 

  • Okpanyi V, Schneider DT, Zahn S et al (2011) Analysis of the adenomatous polyposis coli (APC) gene in childhood and adolescent germ cell tumors. Pediatr Blood Cancer 56:384–391

    Article  Google Scholar 

  • Oosterhuis JW, Looijenga LH (2005) Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer 5:210–222

    Article  CAS  Google Scholar 

  • Palmer RD, Barbosa-Morais NL, Gooding EL et al (2008) Pediatric malignant germ cell tumors show characteristic transcriptome profiles. Cancer Res 68:4239–4247

    Article  CAS  Google Scholar 

  • Palmer RD, Murray MJ, Saini HK et al (2010) Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets. Cancer Res 70:2911–2923

    Article  CAS  Google Scholar 

  • Perlman EJ, Cushing B, Hawkins E et al (1994) Cytogenetic analysis of childhood endodermal sinus tumors: a Pediatric Oncology Group study. Pediatr Pathol 14:695–708

    Article  CAS  Google Scholar 

  • Pleskacova J, Hersmus R, Oosterhuis JW et al (2010) Tumor risk in disorders of sex development. Sex Dev 4(4–4):259–269

    Article  CAS  Google Scholar 

  • Rapley EA, Hockley S, Warren W et al (2004) Somatic mutations of KIT in familial testicular germ cell tumours. Br J Cancer 90:2397–2401

    Article  CAS  Google Scholar 

  • Riopel MA, Spellerberg A, Griffin CA et al (1998) Genetic analysis of ovarian germ cell tumors by comparative genomic hybridization. Cancer Res 58:3105–3110

    CAS  PubMed  Google Scholar 

  • Schmidt P, Haas RJ, Göbel U et al (2002) Results of the German studies (MAHO) for treatment of testicular germ cell tumors in children – an update. Klin Pädiatr 214:167–172

    Article  CAS  Google Scholar 

  • Schneider DT (2015) Sex cord stromal tumors: it is networking-or not working. Pediatr Blood Cancer 62:2065–2066

    Article  Google Scholar 

  • Schneider DT, Hilgenfeld E, Schwabe D et al (1999) Acute myelogenous leukemia after treatment for malignant germ cell tumors in children. J Clin Oncol 17:3226–3233

    Article  CAS  Google Scholar 

  • Schneider DT, Calaminus G, Reinhard H et al (2000) Primary mediastinal germ cell tumors in children and adolescents: results of the German cooperative protocols MAKEI 83/86, 89, and 96. J Clin Oncol 18:832–839

    Article  CAS  Google Scholar 

  • Schneider DT, Schuster AE, Fritsch MK et al (2001a) Genetic analysis of childhood germ cell tumors with comparative genomic hybridization. Klin Pädiatr 213:204–211

    Article  CAS  Google Scholar 

  • Schneider DT, Calaminus G, Göbel U (2001b) Diagnostic value of alpha 1-fetoprotein and beta-human chorionic gonadotropin in infancy and childhood. Pediatr Hematol Oncol 18:11–26

    Article  CAS  Google Scholar 

  • Schneider DT, Schuster AE, Fritsch MK et al (2001c) Multipoint imprinting analysis indicates a common precursor cell for gonadal and nongonadal pediatric germ cell tumors. Cancer Res 61:7268–7276

    CAS  PubMed  Google Scholar 

  • Schneider DT, Calaminus G, Koch S et al (2004) Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols. Pediatr Blood Cancer 42:169–175

    Article  Google Scholar 

  • Schneider DT, Calaminus G, Harms D et al (2005) Ovarian sex cord-stromal tumors in children and adolescents. J Reprod Med 50:439–446

    PubMed  Google Scholar 

  • Sievers S, Alemazkour K, Zahn S et al (2005) IGF2/H19 imprinting analysis with the methylation-sensitive single nucleotide primer extension method in human germ cell tumors reflects their origin from different stages of primordial germ cell development. Genes Chromosomes Cancer 44:256–264

    Article  CAS  Google Scholar 

  • Slade I, Bacchelli C, Davies H et al (2011) DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome. J Med Genet 48:273–278

    Article  CAS  Google Scholar 

  • Skakkebaek NE (2004) Testicular dysgenesis syndrome: new epidemiological evidence. Int J Androl 27:189–191

    Article  Google Scholar 

  • Tröbs RB, Krauss M, Geyer C et al (2007) Surgery in infants and children with testicular and paratesticular tumours: a single centre experience over a 25-year-period. Klin Padiatr 219:146–151

    Article  Google Scholar 

  • Wessalowski R, Blohm M, Calaminus G et al (1997) Treatment results in children and adolescents with loco-regional recurrences of abdominal germ cell tumors (GCTs): a pilot-study with PEI chemotherapy and regional deep hyperthermia (RHT) in comparison to a matched cohort. Klin Pädiatr 209:250–256

    Article  CAS  Google Scholar 

  • Wessalowski R, Schneider DT, Mils O et al (2003) An approach to cure: PEI chemotherapy and regional deep hyperthermia in children and adolescents with unresectable malignant tumors. Klin Pädiatr 215:303–309

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Kinder-und Jugendmedizin, Klinikum Dortmund, Dortmund, Deutschland

    Dominik T. Schneider

Authors
  1. Dominik T. Schneider
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dominik T. Schneider .

Editor information

Editors and Affiliations

  1. Helios Marien Klinikum Duisburg, Duisburg, Nordrhein-Westfalen, Germany

    Herbert Rübben

  2. Urologische Klinik/Poliklinik, Universitätsklinikum Rostock, Rostock, Mecklenburg-Vorpommern, Germany

    Oliver Hakenberg

  3. Klinik und Poliklinik für Urologie , Universitätsklinikum Jena, Jena, Thüringen, Germany

    Marc-Oliver Grimm

  4. Caritaskrankenhaus St. Josef, Regensburg, Germany

    Maximilian Burger

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Schneider, D.T. (2019). Keimzelltumoren und seltene gonadale Tumoren bei Kindern und Jugendlichen. In: Rübben, H., Hakenberg, O., Grimm, MO., Burger, M. (eds) Uroonkologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54652-9_79-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-54652-9_79-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-54652-9

  • Online ISBN: 978-3-662-54652-9

  • eBook Packages: Springer Referenz Medizin

Publish with us

Policies and ethics

Search

Navigation