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Molekulare Grundlagen der Karzinogenese und molekularbiologische Untersuchungsmethoden

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Uroonkologie

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Durch die Entwicklung von zielgerichteten Medikamenten („targeted drugs“), deren Wirksamkeit auf der Inhibition bedeutsamer biologischer Prozesse der Tumorzellen und anderer Zellen im Tumor beruht, hat die Kenntnis molekularer Veränderungen solider Tumoren einen neuen Stellenwert im klinischen Alltag erhalten. Darüber hinaus bilden sie die Grundlage der „molekularen Diagnostik“. Diese eignet sich nicht nur zum Nachweis von Tumoren, sondern wird uns in die Lage versetzen, die Prognose und das Therapieansprechen für den einzelnen Patienten individuell zu definieren. Dies kann z. B. für die Einschätzung der Prognose nach operativer Therapie, die Wahl einer Therapie (z. B. adjuvant) oder die Auswahl von „targeted drugs“ genutzt werden.

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Literatur

  • Albala J, Humphrey-Smith I (2003) Protein arrays, biochips, and proteomics. The next phase of genomic discovery. Dekker, New York

    Book  Google Scholar 

  • Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, Colaprico A, Wendl MC, Kim J, Reardon B, Ng PKS, Jeong KJ, Cao S, Wang ZX, Gao JJ, Gao QS, Wang F, Liu EM, Mularoni L, Rubio-Perez C, Nagarajan N, Cortes-Ciriano I, Zhou DC, Liang WW, Hess JM, Yellapantula VD, Tamborero D, Gonzalez-Perez A, Suphavilai C, Ko JY, Khurana E, Park PJ, Van Allen EM, Liang H, Lawrence MS, Godzik A, Lopez-Bigas N, Stuart J, Wheeler D, Getz G, Chen K, Lazar AJ, Mills GB, Karchin R, Ding L, Grp MW, Network CGAR (2018) Comprehensive characterization of cancer driver genes and mutations. Cell 173:371–385

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, Orntoft T, Lukas J, Bartek J (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434:864–870

    Article  CAS  PubMed  Google Scholar 

  • Baylin SB, Jones PA (2016) Epigenetic determinants of cancer. Csh Perspect Biol 8

    Google Scholar 

  • Beaudet AL, Belmont JW (2008) Array-based DNA diagnostics: let the revolution begin. Annu Rev Med 59:113–129

    Article  CAS  PubMed  Google Scholar 

  • Bernot A (2004) Genome, transcriptome and proteome analysis. Wiley, Hoboken/Weinheim

    Google Scholar 

  • Besaratinia A, Cockburn M, Tommasi S (2013) Alterations of DNA methylome in human bladder cancer. Epigenetics 8:1013–1022

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Blume-Jensen P, Hunter T (2001) Oncogenic kinase signalling. Nature 411:355–365

    Article  CAS  PubMed  Google Scholar 

  • Brabletz T (2012) EMT and MET in metastasis: where are the cancer stem cells? Cancer cell 22:699–701

    Article  CAS  PubMed  Google Scholar 

  • Cancer Genome Atlas Research N (2014) Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 507:315–322

    Article  CAS  Google Scholar 

  • Cancer Genome Atlas Research N, Creighton CJ, Morgan M, Gunaratne PH, Wheeler DA, Gibbs RA, Robertson AG, Chu A, Beroukhim R, Cibulskis K, Signoretti S, Vandin F, Wu H-T, Raphael BJ, Verhaak RGW, Tamboli P, Torres-Garcia W, Akbani R, Weinstein JN, Reuter V, Hsieh JJ, Brannon AR, Hakimi AA, Jacobsen A, Ciriello G, Reva B, Ricketts CJ, Linehan WM, Stuart JM, Rathmell WK, Shen H, Laird PW, Muzny D, Davis C, Morgan M, Xi L, Chang K, Kakkar N, Trevino LR, Benton S, Reid JG, Morton D, Doddapaneni H, Han Y, Lewis L, Dinh H, Kovar C, Zhu Y, Santibanez J, Wang M, Hale W, Kalra D, Creighton CJ, Wheeler DA, Gibbs RA, Getz G, Cibulskis K, Lawrence MS, Sougnez C, Carter SL, Sivachenko A, Lichtenstein L, Stewart C, Voet D, Fisher S, Gabriel SB, Lander E, Beroukhim R, Schumacher SE, Tabak B, Saksena G, Onofrio RC, Carter SL, Cherniack AD, Gentry J, Ardlie K, Sougnez C, Getz G, Gabriel SB, Meyerson M, Robertson AG, Chu A, Chun H-JE, Mungall AJ, Sipahimalani P, Stoll D, Ally A, Balasundaram M, Butterfield YSN, Carlsen R, Carter C, Chuah E, Coope RJN, Dhalla N, Gorski S, Guin R, Hirst C, Hirst M, Holt RA, Lebovitz C, Lee D, Li HI, Mayo M, Moore RA, Pleasance E, Plettner P, Schein JE, Shafiei A, Slobodan JR, Tam A, Thiessen N, Varhol RJ, Wye N, Zhao Y, Birol I, Jones SJM, Marra MA, Auman JT, Tan D, Jones CD, Hoadley KA, Mieczkowski PA, Mose LE, Jefferys SR, Topal MD, Liquori C, Turman YJ, Shi Y, Waring S, Buda E, Walsh J, Wu J, Bodenheimer T, Hoyle AP, Simons JV, Soloway MG, Balu S, Parker JS, Hayes DN, Perou CM, Kucherlapati R, Park P, Shen H, Triche T Jr, Weisenberger DJ, Lai PH, Bootwalla MS, Maglinte DT, Mahurkar S, Berman BP, Van Den Berg DJ, Cope L, Baylin SB, Laird PW, Creighton CJ, Wheeler DA, Getz G, Noble MS, DiCara D, Zhang H, Cho J, Heiman DI, Gehlenborg N, Voet D, Mallard W, Lin P, Frazer S, Stojanov P, Liu Y, Zhou L, Kim J, Lawrence MS, Chin L, Vandin F, Wu H-T, Raphael BJ, Benz C, Yau C, Reynolds SM, Shmulevich I, Verhaak RGW, Torres-Garcia W, Vegesna R, Kim H, Zhang W, Cogdell D, Jonasch E, Ding Z, Lu Y, Akbani R, Zhang N, Unruh AK, Casasent TD, Wakefield C, Tsavachidou D, Chin L, Mills GB, Weinstein JN, Jacobsen A, Brannon R, Ciriello G, Schultz N, Hakimi AA, Reva B, Antipin Y, Gao J, Cerami E, Gross B, Aksoy BA, Sinha R, Weinhold N, Sumer SO, Taylor BS, Shen R, Ostrovnaya I, Hsieh JJ, Berger MF, Ladanyi M, Sander C, Fei SS, Stout A, Spellman PT, Rubin DL, Liu TT, Stuart JM, Ng S, Paull EO, Carlin D, Goldstein T, Waltman P, Ellrott K, Zhu J, Haussler D, Gunaratne PH, Xiao W, Shelton C, Gardner J, Penny R, Sherman M, Mallery D, Morris S, Paulauskis J, Burnett K, Shelton T, Signoretti S, Kaelin WG, Choueiri T, Atkins MB, Penny R, Burnett K, Mallery D, Curley E, Tickoo S, Reuter V, Rathmell WK, Thorne L, Boice L, Huang M, Fisher JC, Linehan WM, Vocke CD, Peterson J, Worrell R, Merino MJ, Schmidt LS, Tamboli P, Czerniak BA, Aldape KD, Wood CG, Boyd J, Weaver J, Iacocca MV, Petrelli N, Witkin G, Brown J, Czerwinski C, Huelsenbeck-Dill L, Rabeno B, Myers J, Morrison C, Bergsten J, Eckman J, Harr J, Smith C, Tucker K, Zach LA, Bshara W, Gaudioso C, Morrison C, Dhir R, Maranchie J, Nelson J, Parwani A, Potapova O, Fedosenko K, Cheville JC, Thompson RH, Signoretti S, Kaelin WG, Atkins MB, Tickoo S, Reuter V, Linehan WM, Vocke CD, Peterson J, Merino MJ, Schmidt LS, Tamboli P, Mosquera JM, Rubin MA, Blute ML, Rathmell WK, Pihl T, Jensen M, Sfeir R, Kahn A, Chu A, Kothiyal P, Snyder E, Pontius J, Ayala B, Backus M, Walton J, Baboud J, Berton D, Nicholls M, Srinivasan D, Raman R, Girshik S, Kigonya P, Alonso S, Sanbhadti R, Barletta S, Pot D, Sheth M, Demchok JA, Davidsen T, Wang Z, Yang L, Tarnuzzer RW, Zhang J, Eley G, Ferguson ML, Mills Shaw KR, Guyer MS, Ozenberger BA, Sofia HJ (2013) Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 499:43–49

    Article  CAS  Google Scholar 

  • Cancer Genome Atlas Research N, Abeshouse A, Ahn J, Akbani R, Ally A, Amin S, Andry CD, Annala M, Aprikian A, Armenia J, Arora A, Auman JT, Balasundaram M, Balu S, Barbieri CE, Bauer T, Benz CC, Bergeron A, Beroukhim R, Berrios M, Bivol A, Bodenheimer T, Boice L, Bootwalla MS, Borges dos Reis R, Boutros PC, Bowen J, Bowlby R, Boyd J, Bradley RK, Breggia A, Brimo F, Bristow CA, Brooks D, Broom BM, Bryce AH, Bubley G, Burks E, Butterfield YSN, Button M, Canes D, Carlotti CG, Carlsen R, Carmel M, Carroll PR, Carter SL, Cartun R, Carver BS, Chan JM, Chang MT, Chen Y, Cherniack AD, Chevalier S, Chin L, Cho J, Chu A, Chuah E, Chudamani S, Cibulskis K, Ciriello G, Clarke A, Cooperberg MR, Corcoran NM, Costello AJ, Cowan J, Crain D, Curley E, David K, Demchok JA, Demichelis F, Dhalla N, Dhir R, Doueik A, Drake B, Dvinge H, Dyakova N, Felau I, Ferguson ML, Frazer S, Freedland S, Fu Y, Gabriel SB, Gao J, Gardner J, Gastier-Foster JM, Gehlenborg N, Gerken M, Gerstein MB, Getz G, Godwin AK, Gopalan A, Graefen M, Graim K, Gribbin T, Guin R, Gupta M, Hadjipanayis A, Haider S, Hamel L, Hayes DN, Heiman DI, Hess J, Hoadley KA, Holbrook AH, Holt RA, Holway A, Hovens CM, Hoyle AP, Huang M, Hutter CM, Ittmann M, Iype L, Jefferys SR, Jones CD, Jones SJM, Juhl H, Kahles A, Kane CJ, Kasaian K, Kerger M, Khurana E, Kim J, Klein RJ, Kucherlapati R, Lacombe L, Ladanyi M, Lai PH, Laird PW, Lander ES, Latour M, Lawrence MS, Lau K, LeBien T, Lee D, Lee S, Lehmann K-V, Leraas KM, Leshchiner I, Leung R, Libertino JA, Lichtenberg TM, Lin P, Linehan WM, Ling S, Lippman SM, Liu J, Liu W, Lochovsky L, Loda M, Logothetis C, Lolla L, Longacre T, Lu Y, Luo J, Ma Y, Mahadeshwar HS, Mallery D, Mariamidze A, Marra MA, Mayo M, McCall S, McKercher G, Meng S, Mes-Masson A-M, Merino MJ, Meyerson M, Mieczkowski PA, Mills GB, Mills Shaw KR, Minner S, Moinzadeh A, Moore RA, Morris S, Morrison C, Mose LE, Mungall AJ, Murray BA, Myers JB, Naresh R, Nelson J, Nelson MA, Nelson PS, Newton Y, Noble MS, Noushmehr H, Nykter M, Pantazi A, Parfenov M, Park PJ, Parker JS, Paulauskis J, Penny R, Perou CM, Piche A, Pihl T, Pinto PA, Prandi D, Protopopov A, Ramirez NC, Rao A, Rathmell WK, Ratsch G, Ren X, Reuter VE, Reynolds SM, Rhie SK, Rieger-Christ K, Roach J, Robertson AG, Robinson B, Rubin MA, Saad F, Sadeghi S, Saksena G, Saller C, Salner A, Sanchez-Vega F, Sander C, Sandusky G, Sauter G, Sboner A, Scardino PT, Scarlata E, Schein JE, Schlomm T, Schmidt LS, Schultz N, Schumacher SE, Seidman J, Neder L, Seth S, Sharp A, Shelton C, Shelton T, Shen H, Shen R, Sherman M, Sheth M, Shi Y, Shih J, Shmulevich I, Simko J, Simon R, Simons JV, Sipahimalani P, Skelly T, Sofia HJ, Soloway MG, Song X, Sorcini A, Sougnez C, Stepa S, Stewart C, Stewart J, Stuart JM, Sullivan TB, Sun C, Sun H, Tam A, Tan D, Tang J, Tarnuzzer R, Tarvin K, Taylor BS, Teebagy P, Tenggara I, Tetu B, Tewari A, Thiessen N, Thompson T, Thorne LB, Tirapelli DP, Tomlins SA, Trevisan FA, Troncoso P, True LD, Tsourlakis MC, Tyekucheva S, Van Allen E, Van Den Berg DJ, Veluvolu U, Verhaak R, Vocke CD, Voet D, Wan Y, Wang Q, Wang W, Wang Z, Weinhold N, Weinstein JN, Weisenberger DJ, Wilkerson MD, Wise L, Witte J, Wu C-C, Wu J, Wu Y, Xu AW, Yadav SS, Yang L, Yang L, Yau C, Ye H, Yena P, Zeng T, Zenklusen JC, Zhang H, Zhang J, Zhang J, Zhang W, Zhong Y, Zhu K, Zmuda E (2015) The molecular taxonomy of primary prostate cancer. Cell 163:1011–1025

    Article  CAS  Google Scholar 

  • Castedo M, Perfettini JL, Roumie T, Andreau K, Medema R, Kroemer G (2004) Cell death by mitotic catastrophe: a molecular definition. Oncogene 23:2825–2837

    Article  CAS  PubMed  Google Scholar 

  • Chen H, Yu Y, Rong S, Wang H (2014) Evaluation of diagnostic accuracy of DNA methylation biomarkers for bladder cancer: a systematic review and meta-analysis. Biomarkers 19:189–197

    Article  CAS  PubMed  Google Scholar 

  • Chen L, Yuan LS, Qian KY, Qian GF, Zhu Y, Wu CL, Dan HC, Xiao Y, Wang XH (2018) Identification of biomarkers associated with pathological stage and prognosis of clear cell renal cell carcinoma by co-expression network analysis. Front Physiol 9

    Google Scholar 

  • Choueiri TK, Motzer RJ (2017) Systemic therapy for metastatic renal-cell carcinoma. New Engl J Med 376:354–366

    Article  CAS  PubMed  Google Scholar 

  • Clark SJ, Harrison J, Paul CL, Frommer M (1994) High sensitivity mapping of methylated cytosines. Nucleic Acids Res 22:2990–2997

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cools-Lartigue J, Spicer J, McDonald B, Gowing S, Chow S, Giannias B, Bourdeau F, Kubes P, Ferri L (2013) Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. J Clin Investig 123:3446–3458

    Article  CAS  PubMed Central  Google Scholar 

  • Cory S, Huang DCS, Adams JM (2003) The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22:8590–8607

    Article  CAS  PubMed  Google Scholar 

  • Cucchiara V, Cooperberg MR, Dall'Era M, Lin DW, Montorsi F, Schalken JA, Evans CP (2018) Genomic markers in prostate cancer decision making. Eur Urol 73:572–582

    Article  PubMed  Google Scholar 

  • Dawson MA, Kouzarides T (2012) Cancer epigenetics: from mechanism to therapy. Cell 150:12–27

    Article  CAS  PubMed  Google Scholar 

  • De Craene B, Berx G (2013) Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer 13:97–110

    Article  PubMed  CAS  Google Scholar 

  • Denny SK, Yang D, Chuang CH, Brady JJ, Lim JS, Gruner BM, Chiou SH, Schep AN, Baral J, Hamard C, Antoine M, Wislez M, Kong CS, Connolly AJ, Park KS, Sage J, Greenleaf WJ, Winslow MM (2016) Nfib promotes metastasis through a widespread increase in chromatin accessibility. Cell 166:328–342

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Di Martino E, Tomlinson DC, Williams SV, Knowles MA (2016) A place for precision medicine in bladder cancer: targeting the FGFRs. Future Oncol 12:2243–2263

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Di Resta C, Galbiati S, Carrera P, Ferrari M (2018) Next-generation sequencing approach for the diagnosis of human diseases: open challenges and new opportunities. Ejifcc 29:4–14

    PubMed  PubMed Central  Google Scholar 

  • van Dijk EL, Jaszczyszyn Y, Naquin D, Thermes C (2018) The third revolution in sequencing technology. Trends Genet 34:666–681

    Google Scholar 

  • Duffy MJ, Sturgeon CM, Soletormos G, Barak V, Molina R, Hayes DF, Diamandis EP, Bossuyt PMM (2015) Validation of new cancer biomarkers: a position statement from the European group on tumor markers. Clin Chem 61:809–820

    Article  CAS  PubMed  Google Scholar 

  • Evan GI, Vousden KH (2001) Proliferation, cell cycle and apoptosis in cancer. Nature 411:342–348

    Article  CAS  PubMed  Google Scholar 

  • Fatica A, Bozzoni I (2014) Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet 15:7–21

    Article  CAS  PubMed  Google Scholar 

  • Feinberg AP, Tycko B (2004) Timeline – The history of cancer epigenetics. Nat Rev Cancer 4:143–153

    Article  CAS  PubMed  Google Scholar 

  • Fidler IJ, Paget S (2003) The pathogenesis of cancer metastasis: the ‚seed and soil‘ hypothesis revisited. Nat Rev Cancer 3:453–458

    Article  CAS  PubMed  Google Scholar 

  • Goering W, Kloth M, Schulz WA (2012) DNA methylation changes in prostate cancer. Methods Mol Biol 863:47–66

    Article  CAS  PubMed  Google Scholar 

  • Grimm MO, Burchardt M, Schulz WA (2003) [Perspectives for molecular diagnostics exemplified by urothelial bladder carcinoma]. Perspektiven der molekularen Diagnostik dargestellt am Beispiel des Harnblasenkarzinoms. Der Urologe Ausg A 42:650–659

    Article  PubMed  Google Scholar 

  • Ha M, Kim VN (2014) Regulation of microRNA biogenesis. Nat Rev Mol Cell Bio 15:509–524

    Article  CAS  Google Scholar 

  • Haese A, de la Taille A, van Poppel H, Marberger M, Stenzl A, Mulders PFA, Huland H, Abbou CC, Remzi M, Tinzl M, Feyerabend S, Stillebroer AB, van Gils MPMQ, Schalken JA (2008) Clinical utility of the PCA3 urine assay in European men scheduled for repeat biopsy. Eur Urol 54:1081–1088

    Article  PubMed  Google Scholar 

  • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70

    Article  CAS  PubMed  Google Scholar 

  • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674

    Article  CAS  PubMed  Google Scholar 

  • He ZH, Tang FC, Lu ZC, Huang YC, Lei HQ, Li ZB, Zeng GH (2018) Analysis of differentially expressed genes, clinical value and biological pathways in prostate cancer. Am J Transl Res 10:1444–1456

    CAS  PubMed  PubMed Central  Google Scholar 

  • Heldin CH (1995) Dimerization of cell-surface receptors in signal-transduction. Cell 80:213–223

    Article  CAS  PubMed  Google Scholar 

  • Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Mark MT, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK, Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K, Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn AJ, Bissell MJ, Garcia BA, Kang Y, Rajasekhar VK, Ghajar CM, Matei I, Peinado H, Bromberg J, Lyden D (2015) Tumour exosome integrins determine organotropic metastasis. Nature 527:329–339

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Inamura K (2018) Bladder cancer: new insights into its molecular pathology. Cancers 10:100

    Google Scholar 

  • Jones PA, Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3:415–428

    Article  CAS  PubMed  Google Scholar 

  • Jones PA, Issa JPJ, Baylin S (2016) Targeting the cancer epigenome for therapy. Nat Rev Genet 17:630–641

    Article  CAS  PubMed  Google Scholar 

  • Joosten SC, Smits KM, Aarts MJ, Melotte V, Koch A, Tjan-Heijnen VC, van Engeland M (2018) Epigenetics in renal cell cancer: mechanisms and clinical applications. Nat Rev Urol 15:430–451

    Article  CAS  PubMed  Google Scholar 

  • Junker K, Fritsch T, Hartmann A, Schulze W, Schubert J (2006) Multicolor fluorescence in situ hybridization (M-FISH) on cells from urine for the detection of bladder cancer. Cytogenet Genome Res 114:279–283

    Article  CAS  PubMed  Google Scholar 

  • Kaplan RN, Rafii S, Lyden D (2006) Preparing the „soil“: the premetastatic niche. Cancer Res 66:11089–11093

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Knijnenburg TA, Wang L, Zimmermann MT, Chambwe N, Gao GF, Cherniack AD, Fan H, Shen H, Way GP, Greene CS, Liu Y, Akbani R, Feng B, Donehower LA, Miller C, Shen Y, Karimi M, Chen H, Kim P, Jia P, Shinbrot E, Zhang S, Liu J, Hu H, Bailey MH, Yau C, Wolf D, Zhao Z, Weinstein JN, Li L, Ding L, Mills GB, Laird PW, Wheeler DA, Shmulevich I, Cancer Genome Atlas Research N, Monnat RJ Jr, Xiao Y, Wang C, Caesar-Johnson SJ, Demchok JA, Felau I, Kasapi M, Ferguson ML, Hutter CM, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Zhang JJ, Chudamani S, Liu J, Lolla L, Naresh R, Pihl T, Sun Q, Wan Y, Wu Y, Cho J, DeFreitas T, Frazer S, Gehlenborg N, Getz G, Heiman DI, Kim J, Lawrence MS, Lin P, Meier S, Noble MS, Saksena G, Voet D, Zhang H, Bernard B, Chambwe N, Dhankani V, Knijnenburg T, Kramer R, Leinonen K, Liu Y, Miller M, Reynolds S, Shmulevich I, Thorsson V, Zhang W, Akbani R, Broom BM, Hegde AM, Ju Z, Kanchi RS, Korkut A, Li J, Liang H, Ling S, Liu W, Lu Y, Mills GB, Ng K-S, Rao A, Ryan M, Wang J, Weinstein JN, Zhang J, Abeshouse A, Armenia J, Chakravarty D, Chatila WK, de Bruijn I, Gao J, Gross BE, Heins ZJ, Kundra R, La K, Ladanyi M, Luna A, Nissan MG, Ochoa A, Phillips SM, Reznik E, Sanchez-Vega F, Sander C, Schultz N, Sheridan R, Sumer SO, Sun Y, Taylor BS, Wang J, Zhang H, Anur P, Peto M, Spellman P, Benz C, Stuart JM, Wong CK, Yau C, Hayes DN, Parker JS, Wilkerson MD, Ally A, Balasundaram M, Bowlby R, Brooks D, Carlsen R, Chuah E, Dhalla N, Holt R, Jones SJM, Kasaian K, Lee D, Ma Y, Marra MA, Mayo M, Moore RA, Mungall AJ, Mungall K, Robertson AG, Sadeghi S, Schein JE, Sipahimalani P, Tam A, Thiessen N, Tse K, Wong T, Berger AC, Beroukhim R, Cherniack AD, Cibulskis C, Gabriel SB, Gao GF, Ha G, Meyerson M, Schumacher SE, Shih J, Kucherlapati MH, Kucherlapati RS, Baylin S, Cope L, Danilova L, Bootwalla MS, Lai PH, Maglinte DT, Van Den Berg DJ, Weisenberger DJ, Auman JT, Balu S, Bodenheimer T, Fan C, Hoadley KA, Hoyle AP, Jefferys SR, Jones CD, Meng S, Mieczkowski PA, Mose LE, Perou AH, Perou CM, Roach J, Shi Y, Simons JV, Skelly T, Soloway MG, Tan D, Veluvolu U, Fan H, Hinoue T, Laird PW, Shen H, Zhou W, Bellair M, Chang K, Covington K, Creighton CJ, Dinh H, Doddapaneni H, Donehower LA, Drummond J, Gibbs RA, Glenn R, Hale W, Han Y, Hu J, Korchina V, Lee S, Lewis L, Li W, Liu X, Morgan M, Morton D, Muzny D, Santibanez J, Sheth M, Shinbrot E, Wang L, Wang M, Wheeler DA, Xi L, Zhao F, Hess J, Appelbaum EL, Bailey M, Cordes MG, Ding L, Fronick CC, Fulton LA, Fulton RS, Kandoth C, Mardis ER, McLellan MD, Miller CA, Schmidt HK, Wilson RK, Crain D, Curley E, Gardner J, Lau K, Mallery D, Morris S, Paulauskis J, Penny R, Shelton C, Shelton T, Sherman M, Thompson E, Yena P, Bowen J, Gastier-Foster JM, Gerken M, Leraas KM, Lichtenberg TM, Ramirez NC, Wise L, Zmuda E, Corcoran N, Costello T, Hovens C, Carvalho AL, de Carvalho AC, Fregnani JH, Longatto-Filho A, Reis RM, Scapulatempo-Neto C, Silveira HCS, Vidal DO, Burnette A, Eschbacher J, Hermes B, Noss A, Singh R, Anderson ML, Castro PD, Ittmann M, Huntsman D, Kohl B, Le X, Thorp R, Andry C, Duffy ER, Lyadov V, Paklina O, Setdikova G, Shabunin A, Tavobilov M, McPherson C, Warnick R, Berkowitz R, Cramer D, Feltmate C, Horowitz N, Kibel A, Muto M, Raut CP, Malykh A, Barnholtz-Sloan JS, Barrett W, Devine K, Fulop J, Ostrom QT, Shimmel K, Wolinsky Y, Sloan AE, De Rose A, Giuliante F, Goodman M, Karlan BY, Hagedorn CH, Eckman J, Harr J, Myers J, Tucker K, Zach LA, Deyarmin B, Hu H, Kvecher L, Larson C, Mural RJ, Somiari S, Vicha A, Zelinka T, Bennett J, Iacocca M, Rabeno B, Swanson P, Latour M, Lacombe L, Tetu B, Bergeron A, McGraw M, Staugaitis SM, Chabot J, Hibshoosh H, Sepulveda A, Su T, Wang T, Potapova O, Voronina O, Desjardins L, Mariani O, Roman-Roman S, Sastre X, Stern M-H, Cheng F, Signoretti S, Berchuck A, Bigner D, Lipp E, Marks J, McCall S, McLendon R, Secord A, Sharp A, Behera M, Brat DJ, Chen A, Delman K, Force S, Khuri F, Magliocca K, Maithel S, Olson JJ, Owonikoko T, Pickens A, Ramalingam S, Shin DM, Sica G, Van Meir EG, Zhang H, Eijckenboom W, Gillis A, Korpershoek E, Looijenga L, Oosterhuis W, Stoop H, van Kessel KE, Zwarthoff EC, Calatozzolo C, Cuppini L, Cuzzubbo S, DiMeco F, Finocchiaro G, Mattei L, Perin A, Pollo B, Chen C, Houck J, Lohavanichbutr P, Hartmann A, Stoehr C, Stoehr R, Taubert H, Wach S, Wullich B, Kycler W, Murawa D, Wiznerowicz M, Chung K, Edenfield WJ, Martin J, Baudin E, Bubley G, Bueno R, De Rienzo A, Richards WG, Kalkanis S, Mikkelsen T, Noushmehr H, Scarpace L, Girard N, Aymerich M, Campo E, Gine E, Guillermo AL, Van Bang N, Hanh PT, Phu BD, Tang Y, Colman H, Evason K, Dottino PR, Martignetti JA, Gabra H, Juhl H, Akeredolu T, Stepa S, Hoon D, Ahn K, Kang KJ, Beuschlein F, Breggia A, Birrer M, Bell D, Borad M, Bryce AH, Castle E, Chandan V, Cheville J, Copland JA, Farnell M, Flotte T, Giama N, Ho T, Kendrick M, Kocher J-P, Kopp K, Moser C, Nagorney D, O'Brien D, O'Neill BP, Patel T, Petersen G, Que F, Rivera M, Roberts L, Smallridge R, Smyrk T, Stanton M, Thompson RH, Torbenson M, Yang JD, Zhang L, Brimo F, Ajani JA, Gonzalez AMA, Behrens C, Bondaruk J, Broaddus R, Czerniak B, Esmaeli B, Fujimoto J, Gershenwald J, Guo C, Lazar AJ, Logothetis C, Meric-Bernstam F, Moran C, Ramondetta L, Rice D, Sood A, Tamboli P, Thompson T, Troncoso P, Tsao A, Wistuba I, Carter C, Haydu L, Hersey P, Jakrot V, Kakavand H, Kefford R, Lee K, Long G, Mann G, Quinn M, Saw R, Scolyer R, Shannon K, Spillane A, Stretch J, Synott M, Thompson J, Wilmott J, Al-Ahmadie H, Chan TA, Ghossein R, Gopalan A, Levine DA, Reuter V, Singer S, Singh B, Tien NV, Broudy T, Mirsaidi C, Nair P, Drwiega P, Miller J, Smith J, Zaren H, Park J-W, Hung NP, Kebebew E, Linehan WM, Metwalli AR, Pacak K, Pinto PA, Schiffman M, Schmidt LS, Vocke CD, Wentzensen N, Worrell R, Yang H, Moncrieff M, Goparaju C, Melamed J, Pass H, Botnariuc N, Caraman I, Cernat M, Chemencedji I, Clipca A, Doruc S, Gorincioi G, Mura S, Pirtac M, Stancul I, Tcaciuc D, Albert M, Alexopoulou I, Arnaout A, Bartlett J, Engel J, Gilbert S, Parfitt J, Sekhon H, Thomas G, Rassl DM, Rintoul RC, Bifulco C, Tamakawa R, Urba W, Hayward N, Timmers H, Antenucci A, Facciolo F, Grazi G, Marino M, Merola R, de Krijger R, Gimenez-Roqueplo A-P, Piche A, Chevalier S, McKercher G, Birsoy K, Barnett G, Brewer C, Farver C, Naska T, Pennell NA, Raymond D, Schilero C, Smolenski K, Williams F, Morrison C, Borgia JA, Liptay MJ, Pool M, Seder CW, Junker K, Omberg L, Dinkin M, Manikhas G, Alvaro D, Bragazzi MC, Cardinale V, Carpino G, Gaudio E, Chesla D, Cottingham S, Dubina M, Moiseenko F, Dhanasekaran R, Becker K-F, Janssen K-P, Slotta-Huspenina J, Abdel-Rahman MH, Aziz D, Bell S, Cebulla CM, Davis A, Duell R, Elder JB, Hilty J, Kumar B, Lang J, Lehman NL, Mandt R, Nguyen P, Pilarski R, Rai K, Schoenfield L, Senecal K, Wakely P, Hansen P, Lechan R, Powers J, Tischler A, Grizzle WE, Sexton KC, Kastl A, Henderson J, Porten S, Waldmann J, Fassnacht M, Asa SL, Schadendorf D, Couce M, Graefen M, Huland H, Sauter G, Schlomm T, Simon R, Tennstedt P, Olabode O, Nelson M, Bathe O, Carroll PR, Chan JM, Disaia P, Glenn P, Kelley RK, Landen CN, Phillips J, Prados M, Simko J, Smith-McCune K, VandenBerg S, Roggin K, Fehrenbach A, Kendler A, Sifri S, Steele R, Jimeno A, Carey F, Forgie I, Mannelli M, Carney M, Hernandez B, Campos B, Herold-Mende C, Jungk C, Unterberg A, von Deimling A, Bossler A, Galbraith J, Jacobus L, Knudson M, Knutson T, Ma D, Milhem M, Sigmund R, Godwin AK, Madan R, Rosenthal HG, Adebamowo C, Adebamowo SN, Boussioutas A, Beer D, Giordano T, Mes-Masson A-M, Saad F, Bocklage T, Landrum L, Mannel R, Moore K, Moxley K, Postier R, Walker J, Zuna R, Feldman M, Valdivieso F, Dhir R, Luketich J, Pinero EMM, Quintero-Aguilo M, Carlotti CG Jr, Dos Santos JS, Kemp R, Sankarankuty A, Tirapelli D, Catto J, Agnew K, Swisher E, Creaney J, Robinson B, Shelley CS, Godwin EM, Kendall S, Shipman C, Bradford C, Carey T, Haddad A, Moyer J, Peterson L, Prince M, Rozek L, Wolf G, Bowman R, Fong KM, Yang I, Korst R, Rathmell WK, Fantacone-Campbell JL, Hooke JA, Kovatich AJ, Shriver CD, DiPersio J, Drake B, Govindan R, Heath S, Ley T, Van Tine B, Westervelt P, Rubin MA, Lee JI, Aredes ND, Mariamidze A (2018) Genomic and molecular landscape of DNA damage repair deficiency across the cancer genome atlas. Cell Rep 23:239–254.e236

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP (1998) Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 4:844–847

    Article  CAS  PubMed  Google Scholar 

  • Kozomara A, Griffiths-Jones S (2014) miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res 42:D68–D73

    Article  CAS  PubMed  Google Scholar 

  • Labelle M, Hynes RO (2012) The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov 2:1091–1099

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Labelle M, Begum S, Hynes RO (2011) Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer cell 20:576–590

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lambert AW, Pattabiraman DR, Weinberg RA (2017) Emerging biological principles of metastasis. Cell 168:670–691

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lerner SP, Robertson AG (2016) Molecular subtypes of non-muscle invasive bladder cancer. Cancer cell 30:1–3

    Article  CAS  PubMed  Google Scholar 

  • Li XM, Quigg RJ, Zhou J, Gu WK, Rao PN, Reed EF (2008) Clinical utility of microarrays: current status, existing challenges and future outlook. Curr genomics 9:466–474

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liao PC, Lieu CH (2005) Cell cycle specific induction of apoptosis and necrosis by paclitaxel in the leukemic U937 cells. Life Sci 76:1623–1639

    Article  CAS  PubMed  Google Scholar 

  • Liu XB, Hao YX, Yu W, Yang X, Luo X, Zhao J, Li J, Hu XY, Li LK (2018) Long non-coding RNA emergence during renal cell carcinoma tumorigenesis. Cell Physiol Biochem 47:735–746

    Article  CAS  PubMed  Google Scholar 

  • Los M, Stroh C, Janicke RU, Engels IH, Schulze-Osthoff K (2001) Caspases: more than just killers? Trends Immunol 22:31–34

    Article  CAS  PubMed  Google Scholar 

  • Matsumura H, Ito A, Saitoh H, Winter P, Kahl G, Reuter M, Kruger DH, Terauchi R (2005) SuperSAGE. Cell Microbiol 7:11–18

    Article  CAS  PubMed  Google Scholar 

  • McGrath S, Christidis D, Perera M, Hong SK, Manning T, Vela I, Lawrentschuk N (2016) Prostate cancer biomarkers: are we hitting the mark? Prostate Int 4:130–135

    Article  PubMed  PubMed Central  Google Scholar 

  • Mercer TR, Mattick JS (2013) Structure and function of long noncoding RNAs in epigenetic regulation. Nat Struct Mol Biol 20:300–307

    Article  CAS  PubMed  Google Scholar 

  • Milas L, Milas MM, Mason KA (1999) Combination of taxanes with radiation: preclinical studies. Semin Radiat Oncol 9:12–26

    CAS  PubMed  Google Scholar 

  • Morin RD, Bainbridge M, Fejes A, Hirst M, Krzywinski M, Pugh TJ, McDonald H, Varhol R, Jones SJM, Marra MA (2008) Profiling the HeLa S3 transcriptome using randomly primed cDNA and massively parallel short-read sequencing. Biotech 45:81–94

    Google Scholar 

  • Mülhardt C (2002) Der Experimentator: Molekularbiologie/Genomics, 3. Aufl. Spektrum Akademischer Verlag, Heidelberg/Berlin

    Google Scholar 

  • Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA (2009) MicroRNAs--the micro steering wheel of tumour metastases. Nat Rev Cancer 9:293–302

    Article  CAS  PubMed  Google Scholar 

  • Nieswandt B, Hafner M, Echtenacher B, Mannel DN (1999) Lysis of tumor cells by natural killer cells in mice is impeded by platelets. Cancer Res 59:1295–1300

    CAS  PubMed  Google Scholar 

  • Ozturk S, Papageorgis P, Wong CK, Lambert AW, Abdolmaleky HM, Thiagalingam A, Cohen HT, Thiagalingam S (2016) SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. Proc Natl Acad Sci U S A 113:638–643

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pachmayr E, Treese C, Stein U (2017) Underlying mechanisms for distant metastasis – molecular biology. Visc Med 33:11–20

    Article  PubMed  PubMed Central  Google Scholar 

  • Paget S (1889) The distribution of secondary growths in cancer of the breast. Lancet 1:571–573

    Article  Google Scholar 

  • Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Jirouskova M, Degen JL (2005) Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood 105:178–185

    Article  CAS  PubMed  Google Scholar 

  • Pawlik TM, Keyomarsi K (2004) Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol 59:928–942

    Article  Google Scholar 

  • Peinado H, Lyden D, Bromberg J (2012) Transfer of cargo from exosomes to bone marrow progenitors promotes melanoma metastasis. FEBS J 279:24–24

    Google Scholar 

  • Peinado H, Zhang HY, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang YB, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden D (2017) Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer 17:302–317

    Article  CAS  PubMed  Google Scholar 

  • Perner S, Schmidt FH, Hofer MD, Kuefer R, Rubin M (2007) TMPRSS2-ETS gene fusion in prostate cancer. Urologe 46:754–760

    Article  CAS  Google Scholar 

  • Pinkel D, Albertson DG (2005) Array comparative genomic hybridization and its applications in cancer. Nat Genet 37:S11–S17

    Article  CAS  PubMed  Google Scholar 

  • Plass C, Pfister SM, Lindroth AM, Bogatyrova O, Claus R, Lichter P (2013) Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer. Nat Rev Genet 14:765–780

    Article  CAS  PubMed  Google Scholar 

  • Ricketts CJ, de Cubas AA, Fan HH, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Haake S, Hakimi AA, Henske EP, Hsieh JJ, Ho TH, Kanchi RS, Krishnan B, Kwaitkowski DJ, Lui WB, Merino MJ, Mills GB, Myers J, Nickerson ML, Reuter VE, Schmidt LS, Shelley CS, Shen H, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Vincent BG, Vocke CD, Wheeler DA, Yang LX, Kim WT, Robertson AG, Spellman PT, Rathmell WK, Linehan WM, Network CGAR (2018) The cancer genome atlas comprehensive molecular characterization of renal cell carcinoma. Cell Rep 23:313–326.e315

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo GW, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, Castro MAA, Gibb EA, Kanchi RS, Gordenin DA, Shukla SA, Sanchez-Vega F, Hansel DE, Czerniak BA, Reuter VE, Su XP, de Sa CB, Chagas VS, Mungall KL, Sadeghi S, Pedamallu CS, Lu YL, Klimczak LJ, Zhang JX, Choo C, Ojesina AI, Bullman S, Leraas KM, Lichtenberg TM, Wu CJ, Schultz N, Getz G, Meyerson M, Mills GB, McConkey DJ, Weinstein JN, Kwiatkowski DJ, Lerner SP, Network TR (2018) Comprehensive molecular characterization of muscle-invasive bladder cancer (vol 171, pg 540, 2017). Cell 174:1033–1033

    Article  CAS  PubMed  Google Scholar 

  • Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S, Chakravarty D, Daian F, Gao QS, Bailey MH, Liang WW, Foltz SM, Shmulevich I, Ding L, Heins Z, Ochoa A, Gross B, Gao JJ, Zhang HX, Kundra R, Kandoth C, Bahceci I, Dervishi L, Dogrusoz U, Zhou WD, Shen H, Laird PW, Way GP, Greene CS, Liang H, Xiao YH, Wang C, Iavarone A, Berger AH, Bivona TG, Lazar AJ, Hammer GD, Giordano T, Kwong LN, McArthur G, Huang CF, Tward AD, Frederick MJ, McCormick F, Meyerson M, Van Allen EM, Cherniack AD, Ciriello G, Sander C, Schultz N, Network CGAR (2018) Oncogenic signaling pathways in the cancer genome atlas. Cell 173:321–337

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sanjmyatav J, Junker K, Matthes S, Muehr M, Sava D, Sternal M, Wessendorf S, Kreuz M, Gajda M, Wunderlich H, Schwaenen C (2011a) Identification of genomic alterations associated with metastasis and cancer specific survival in clear cell renal cell carcinoma. J Urol 186:2078–2083

    Article  CAS  PubMed  Google Scholar 

  • Sanjmyatav J, Steiner T, Wunderlich H, Diegmann J, Gajda M, Junker K (2011b) A specific gene expression signature characterizes metastatic potential in clear cell renal cell carcinoma. J Urol 186:289–294

    Article  CAS  PubMed  Google Scholar 

  • Schlessinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103:211–225

    Article  CAS  PubMed  Google Scholar 

  • Schulz W (2005) Molecular biology of human cancers: an advanced student’s textbook. Springer, Berlin/Heidelberg/ New York, S 1–508. https://doi.org/10.1007/978-1-4020-3186-1

  • Schubert M, Junker K, Heinzelmann J (2016) Prognostic and predictive miRNA biomarkers in bladder, kidney and prostate cancer: where do we stand in biomarker development? J Cancer Res Clin 142:1673–1695

    Article  CAS  Google Scholar 

  • Schulz WA, Goering W (2016) DNA methylation in urothelial carcinoma. Epigenomics 8:1415–1428

    Article  CAS  PubMed  Google Scholar 

  • Shen H, Shih J, Hollern DP, Wang LH, Bowlby R, Tickoo SK, Thorsson V, Mungall AJ, Newton Y, Hegde AM, Armenia J, Sanchez-Vega F, Pluta J, Pyle LC, Mehra R, Reuter VE, Godoy G, Jones J, Shelley CS, Feldman DR, Vidal DO, Lesse D, Kulis T, Carcano FM, Leraas KM, Lichtenberg TM, Brooks D, Cherniack AD, Cho J, Heiman DI, Kasaian K, Liu MW, Noble MS, Xi L, Zhang HL, Zhou WD, ZenKlusen JC, Hutter CM, Felau I, Zhang JS, Schultz N, Getz G, Meyerson M, Stuart JM, Akbani R, Wheeler DA, Laird PW, Nathanson KL, Cortessis VK, Hoadley KA, Network CGAR (2018) Integrated molecular characterization of testicular germ cell tumors. Cell Rep 23:3392–3406

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sherr CJ, McCormick F (2002) The RB and p53 pathways in cancer. Cancer cell 2:103–112

    Article  CAS  PubMed  Google Scholar 

  • Siemann DW, Keng PC (1984) In situ radiation response and oxygen enhancement ratio of KHT sarcoma cells in various phases of the cell cycle. Br J Radiol 57:823–827

    Article  CAS  PubMed  Google Scholar 

  • Spiegel A, Brooks MW, Houshyar S, Reinhardt F, Ardolino M, Fessler E, Chen MB, Krall JA, DeCock J, Zervantonakis IK, Iannello A, Iwamoto Y, Cortez-Retamozo V, Kamm RD, Pittet MJ, Raulet DH, Weinberg RA (2016) Neutrophils suppress intraluminal NK cell-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells. Cancer Discov 6:630–649

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Steeg PS (2003) Metastasis suppressors alter the signal transduction of cancer cells. Nat Rev Cancer 3:55–63

    Article  CAS  PubMed  Google Scholar 

  • Stirzaker C, Taberlay PC, Statham AL, Clark SJ (2014) Mining cancer methylomes: prospects and challenges. Trends Genet 30:75–84

    Article  CAS  PubMed  Google Scholar 

  • Sun C, Bernards R (2014) Feedback and redundancy in receptor tyrosine kinase signaling: relevance to cancer therapies. Trends Biochem Sci 39:465–474

    Article  CAS  PubMed  Google Scholar 

  • Sun H, Kim P, Jia P, Park AK, Liang H, Zhao Z (2019) Distinct telomere length and molecular signatures in seminoma and non-seminoma of testicular germ cell tumor. Brief Bioinform 20(4):1502–1512

    Google Scholar 

  • Talmadge JE, Fidler IJ (2010) AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res 70:5649–5669

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Van Neste L, Hendriks RJ, Dijkstra S, Trooskens G, Cornel EB, Jannink SA, de Jong H, Hessels D, Smit FP, Melchers WJG, Leyten GHJM, de Reijke TM, Vergunst H, Kil P, Knipscheer BC, Hulsbergen-van de Kaa CA, Mulders PFA, van Oort IM, Van Criekinge W, Schalken JA (2016) Detection of high-grade prostate cancer using a urinary molecular biomarker-based risk score. Eur Urol 70:740–748

    Article  PubMed  CAS  Google Scholar 

  • Velculescu VE, Zhang L, Vogelstein B, Kinzler KW (1995) Serial analysis of gene-expression. Science 270:484–487

    Article  CAS  PubMed  Google Scholar 

  • van de Vijver MJ, He YD, van’t Veer LJ, Dai H, AAM H, Voskuil DW, Schreiber GJ, Peterse JL, Roberts C, Marton MJ, Parrish M, Atsma D, Witteveen A, Glas A, Delahaye L, van der Velde T, Bartelink H, Rodenhuis S, Rutgers ET, Friend SH, Bernards R (2002) A gene-expression signature as a predictor of survival in breast cancer. New Engl J Med 347:1999–2009

    Google Scholar 

  • Waddington CH (1942) The epigenotype. Endeavour 1:18–20

    Google Scholar 

  • Wang Z, Gerstein M, Snyder M (2009) RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 10:57–63

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wedge DC, Gundem G, Mitchell T, Woodcock DJ, Martincorena I, Ghori M, Zamora J, Butler A, Whitaker H, Kote-Jarai Z, Alexandrov LB, Van Loo P, Massie CE, Dentro S, Warren AY, Verrill C, Berney DM, Dennis N, Merson S, Hawkins S, Howat W, Lu YJ, Lambert A, Kay J, Kremeyer B, Karaszi K, Luxton H, Camacho N, Marsden L, Edwards S, Matthews L, Bo V, Leongamornlert D, McLaren S, Ng A, Yu YW, Zhang HW, Dadaev T, Thomas S, Easton DF, Ahmed M, Bancroft E, Fisher C, Livni N, Nicol D, Tavare S, Gill P, Greenman C, Khoo V, Van As N, Kumar P, Ogden C, Cahill D, Thompson A, Mayer E, Rowe E, Dudderidge T, Gnanapragasam V, Shah NC, Raine K, Jones D, Menzies A, Stebbings L, Teague J, Hazell S, Corbishley C, de Bono J, Attard G, Isaacs W, Visakorpi T, Fraser M, Boutros PC, Bristow RG, Workman P, Sander C, Hamdy FC, Futreal A, McDermott U, Al-Lazikani B, Lynch AG, Bova GS, Foster CS, Brewer DS, Neal DE, Cooper CS, Eeles RA, Grp CS, Consortium T (2018) Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets. Nat Genet 50:682–692

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xin L, Liu Y-H, Martin TA, Jiang WG (2017) The era of multigene panels comes? The clinical utility of oncotype DX and mammaprint. World J Oncol 8:34–40

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xu T, Lin CM, Cheng SQ, Min J, Li L, Meng XM, Huang C, Zhang L, Deng ZY, Li J (2018) Pathological bases and clinical impact of long noncoding RNAs in prostate cancer: a new budding star. Mol Cancer 17(1):103

    Google Scholar 

  • Zawada AM, Rogacev KS, Muller S, Rotter B, Winter P, Fliser D, Heine GH (2014) Massive analysis of cDNA Ends (MACE) and miRNA expression profiling identifies proatherogenic pathways in chronic kidney disease. Epigenetics 9:161–172

    Article  CAS  PubMed  Google Scholar 

  • Zuiverloon TCM, Beukers W, van der Keur KA, Nieuweboer AJM, Reinert T, Dyrskjot L, Orntoft TF, Zwarthoff EC (2013) Combinations of urinary biomarkers for surveillance of patients with incident nonmuscle invasive bladder cancer: the European FP7 UROMOL project. J Urol 189:1945–1951

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Klinik für Urologie, Medizinische Fakultät, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Deutschland

    Michèle J. Hoffmann

  2. Urologische und Kinderurologische Klinik Erlangen, Abt. Molekulare Urologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Deutschland

    Helge Taubert

  3. Klinik für Urologie und Kinderurologie, Universitätsklinikum des Saarlandes, Universität des Saarlandes, Homburg/Saar, Deutschland

    Kerstin Junker

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  1. Helios Marien Klinikum Duisburg, Duisburg, Nordrhein-Westfalen, Germany

    Herbert Rübben

  2. Urologische Klinik/Poliklinik, Universitätsklinikum Rostock, Rostock, Mecklenburg-Vorpommern, Germany

    Oliver Hakenberg

  3. Klinik und Poliklinik für Urologie, Universitätsklinikum Jena, Jena, Thüringen, Germany

    Marc-Oliver Grimm

  4. Caritaskrankenhaus St. Josef, Regensburg, Germany

    Maximilian Burger

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Hoffmann, M.J., Taubert, H., Junker, K. (2020). Molekulare Grundlagen der Karzinogenese und molekularbiologische Untersuchungsmethoden. In: Rübben, H., Hakenberg, O., Grimm, MO., Burger, M. (eds) Uroonkologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54652-9_11-1

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