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Neuroblastom und andere Nebennierentumoren bei Kindern und Jugendlichen

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Book cover Kinderchirurgie

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Das Neuroblastom ist der häufigste, maligne extrakranielle Tumor des Kindesalters. Es gehört zur Gruppe der embryonalen Tumoren mit entsprechender Zellmorphologie und einer starken Bevorzugung des frühen Kindesalters. Es entsteht aus den Neuroblasten des sympathischen Nervensystems, d. h. des Nebennierenmarks, des Grenzstrangs und der sympathischen Paraganglien. Etwa 75 % der Neuroblastome finden sich im Retroperitoneum (davon 50 % ausgehend von den Nebennieren, 25 % vom sympathischen Grenzstrang), 20 % im Thorax, 3–4 % im Becken und 1–2 % im Hals. Das biologische Verhalten von Neuroblastomen ist sehr variabel mit hochmalignem aggressivem Wachstum bis zur Ausdifferenzierung in benigne Ganglioneurome oder bei sehr jungen Kindern auch spontanen Regressionen. Wichtige prognostische Faktoren sind dabei das Alter der Patienten, das Tumorstadium und molekulargenetische Marker.

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Authors and Affiliations

  1. Kinderchirurgische Klinik und Poliklinik, Dr. von Haunersches Kinderspital, München, Deutschland

    Dietrich von Schweinitz

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  1. Dietrich von Schweinitz
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Correspondence to Dietrich von Schweinitz .

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  1. Kinderchirurgische Klinik und Poliklinik, Klinikum der Universität München Kinderchirurgische Klinik und Poliklinik, München, Bayern, Germany

    Dietrich von Schweinitz

  2. Abt. Kinderchirurgie, Medizinische Hochschule Hannover (MHH) Kinderklinik, Hannover, Germany

    Benno Ure

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von Schweinitz, D. (2018). Neuroblastom und andere Nebennierentumoren bei Kindern und Jugendlichen. In: von Schweinitz, D., Ure, B. (eds) Kinderchirurgie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53390-1_84-1

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  • DOI: https://doi.org/10.1007/978-3-662-53390-1_84-1

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