Zusammenfassung
Der Begriff Kurzdarmsyndrom (KDS) beschreibt einen Zustand der Malabsorption, bei dem die verbleibende intestinale Funktion nicht zur Hydratation, der Homöostase der Elektrolyte und einem Gedeihen ausreicht. Das Syndrom tritt meist nach Resektion von großen Dünndarmanteilen auf, kann jedoch in seltenen Fällen auch angeboren sein (Wales et al. 2013). Das KDS ist ebenfalls definiert als die Abhängigkeit von einer parenteralen Ernährung (PN) infolge eines funktionellen oder anatomischen Verlusts von Darm (Andorsky et al. 2001).
This is a preview of subscription content, log in via an institution to check access.
Literatur
Andorsky DJ, Lund DP, Lillehei CW, Jaksic T, Dicanzio J, Richardson DS et al (2001) Nutritional and other postoperative management of neonates with short bowel syndrome correlates with clinical outcomes. J Pediatr 139(1):27–33. https://doi.org/10.1067/mpd.2001.114481
Ardura MI, Lewis J, Tansmore JL, Harp PL, Dienhart MC, Balint JP (2015) Central catheter-associated bloodstream infection reduction with ethanol lock prophylaxis in pediatric intestinal failure. Broadening quality improvement initiatives from hospital to home. JAMA Pediatr 169(4):324–331. https://doi.org/10.1001/jamapediatrics.2014.3291
Ba’ath ME, Almond S, King B, Bianchi A, Khalil BA, Morabito A (2012) Short bowel syndrome. A practical pathway leading to successful enteral autonomy. World J Surg 36(5):1044–1048. https://doi.org/10.1007/s00268-012-1512-5
Bianchi A (1980) Intestinal loop lengthening – a technique for increasing small intestinal length. J Pediatr Surg 15(2):145–151
Carter BA, Cohran VC, Cole CR, Corkins MR, Dimmitt RA, Duggan C et al (2017) Outcomes from a 12-week, open-label, multicenter clinical trial of teduglutide in pediatric short bowel syndrome. J Pediatr 181:102–111.e5. https://doi.org/10.1016/j.jpeds.2016.10.027
Colomb V, Dabbas-Tyan M, Taupin P, Talbotec C, Révillon Y, Jan D et al (2007) Long-term outcome of children receiving home parenteral nutrition. A 20-year single-center experience in 302 patients. J Pediatr Gastroenterol Nutr 44(3):347–353. https://doi.org/10.1097/MPG.0b013e31802c6971
Diamond IR, Grant RC, Pencharz PB, de Silva N, Feldman BM, Fitzgerald P et al (2017) Preventing the progression of intestinal failure-associated liver disease in infants using a composite lipid emulsion. A pilot randomized controlled trial of SMOFlipid. JPEN J Parenter Enteral Nutr 41(5):866–877. https://doi.org/10.1177/0148607115626921
DiBaise JK, Young RJ, Vanderhoof JA (2004) Intestinal rehabilitation and the short bowel syndrome. Part 1. Am J Gastroenterol 99(7):1386–1395. https://doi.org/10.1111/j.1572-0241.2004.30345.x
Duggan CP, Jaksic T (2017) Pediatric intestinal failure. N Engl J Med 377(7):666–675. https://doi.org/10.1056/NEJMra1602650
Fitzgibbons S, Ching YA, Valim C, Zhou J, Iglesias J, Duggan C, Jaksic T (2009) Relationship between serum citrulline levels and progression to parenteral nutrition independence in children with short bowel syndrome. J Pediatr Surg 44(5):928–932. https://doi.org/10.1016/j.jpedsurg.2009.01.034
Frongia G, Kessler M, Weih S, Nickkholgh A, Mehrabi A, Holland-Cunz S (2013) Comparison of LILT and STEP procedures in children with short bowel syndrome – a systematic review of the literature. J Pediatr Surg 48(8):1794–1805. https://doi.org/10.1016/j.jpedsurg.2013.05.018
Goulet O, Olieman J, Ksiazyk J, Spolidoro J, Tibboe D, Köhler H et al (2013) Neonatal short bowel syndrome as a model of intestinal failure. Physiological background for enteral feeding. Clin Nutr 32(2):162–171. https://doi.org/10.1016/j.clnu.2012.09.007
Grant D, Abu-Elmagd K, Mazariegos G, Vianna R, Langnas A, Mangus R et al (2015) Intestinal transplant registry report. Global activity and trends. Am J Transplant 15(1):210–219. https://doi.org/10.1111/ajt.12979
Gutierrez IM, Kang KH, Calvert CE, Johnson VM, Zurakowski D, Kamin D et al (2012) Risk factors for small bowel bacterial overgrowth and diagnostic yield of duodenal aspirates in children with intestinal failure. A retrospective review. J Pediatr Surg 47(6):1150–1154. https://doi.org/10.1016/j.jpedsurg.2012.03.019
Javid PJ, Collier S, Richardson D, Iglesias J, Gura K, Lo C et al (2005) The role of enteral nutrition in the reversal of parenteral nutrition-associated liver dysfunction in infants. J Pediatr Surg 40(6):1015–1018. https://doi.org/10.1016/j.jpedsurg.2005.03.019
Jeppesen PB, Gilroy R, Pertkiewicz M, Allard JP, Messing B, O’Keefe SJ (2011) Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome. Gut 60(7):902–914. https://doi.org/10.1136/gut.2010.218271
Jones BA, Hull MA, Potanos KM, Zurakowski D, Fitzgibbons SC, Ching YA et al (2013) Report of 111 consecutive patients enrolled in the International Serial Transverse Enteroplasty (STEP) data registry. A retrospective observational study. J Am Coll Surg 216(3):438–446. https://doi.org/10.1016/j.jamcollsurg.2012.12.018
Kelly DA (1998) Liver complications of pediatric parenteral nutrition – epidemiology. Nutrition 14(1):153–157
Kim HB, Fauza D, Garza J, Oh J-T, Nurko S, Jaksic T (2003) Serial transverse enteroplasty (STEP). A novel bowel lengthening procedure. J Pediatr Surg 38(3):425–429. https://doi.org/10.1053/jpsu.2003.50073
Kunz AN, Noel JM, Fairchok MP (2004) Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome. J Pediatr Gastroenterol Nutr 38(4):457–458
Mazariegos GV, Steffick DE, Horslen S, Farmer D, Fryer J, Grant D et al (2010) Intestine transplantation in the United States, 1999–2008. Am J Transplant 10(4 Pt 2):1020–1034. https://doi.org/10.1111/j.1600-6143.2010.03044.x
Mercer DF, Hobson BD, Gerhardt BK, Grant WJ, Vargas LM, Langnas AN, Quiros-Tejeira RE (2014) Serial transverse enteroplasty allows children with short bowel to wean from parenteral nutrition. J Pediatr 164(1):93–98. https://doi.org/10.1016/j.jpeds.2013.08.039
Oh PS, Fingeret AL, Shah MY, Ventura KA, Brodlie S, Ovchinsky N et al (2014) Improved tolerance for enteral nutrition after serial transverse enteroplasty (STEP) in infants and children with short bowel syndrome – a seven-year single-center experience. J Pediatr Surg 49(11):1589–1592. https://doi.org/10.1016/j.jpedsurg.2014.07.019
O’Keefe SJD, Jeppesen PB, Gilroy R, Pertkiewicz M, Allard JP, Messing B (2013) Safety and efficacy of teduglutide after 52 weeks of treatment in patients with short bowel intestinal failure. Clin Gastroenterol Hepatol 11(7):815–23.e1-3. https://doi.org/10.1016/j.cgh.2012.12.029
Oliveira C, Nasr A, Brindle M, Wales PW (2012) Ethanol locks to prevent catheter-related bloodstream infections in parenteral nutrition. A meta-analysis. Pediatrics 129(2):318–329. https://doi.org/10.1542/peds.2011-1602
O’Neil M, Teitelbaum DH, Harris MB (2014) Total body sodium depletion and poor weight gain in children and young adults with an ileostomy. A case series. Nutr Clin Prac 29(3):397–401. https://doi.org/10.1177/0884533614528543
Pakarinen MP (2015) Autologous intestinal reconstruction surgery as part of comprehensive management of intestinal failure. Pediatr Surg Int 31(5):453–464. https://doi.org/10.1007/s00383-015-3696-x
Park HW, Lee NM, Kim JH, Kim KS, Kim S-N (2015) Parenteral fish oil-containing lipid emulsions may reverse parenteral nutrition-associated cholestasis in neonates. A systematic review and meta-analysis. J Nutr 145(2):277–283. https://doi.org/10.3945/jn.114.204974
Smith JM, Skeans MA, Horslen SP, Edwards EB, Harper AM, Snyder JJ et al (2017) OPTN/SRTR 2015 annual sata report. Intestine. Am J Transplant 17(Suppl 1):252–285. https://doi.org/10.1111/ajt.14127
Struijs M-C, Diamond IR, de Silva N, Wales PW (2009) Establishing norms for intestinal length in children. J Pediatr Surg 44(5):933–938. https://doi.org/10.1016/j.jpedsurg.2009.01.031
Sudan D (2014) The current state of intestine transplantation. Indications, techniques, outcomes and challenges. Am J Transplant 14(9):1976–1984. https://doi.org/10.1111/ajt.12812
Varkey J, Simrén M, Jalanko H, Oltean M, Saalman R, Gudjonsdottir A et al (2015) Fifteen years’ experience of intestinal and multivisceral transplantation in the Nordic countries. Scand J Gastroenterol 50(3):278–290. https://doi.org/10.3109/00365521.2014.999255
Wales PW, Jancelewicz T, Romao RL, Piper HG, de Silva NT, Avitzur Y (2013) Delayed primary serial transverse enteroplasty as a novel management strategy for infants with congenital ultra-short bowel syndrome. J Pediatr Surg 48(5):993–999. https://doi.org/10.1016/j.jpedsurg.2013.02.015
Weber TR, Powell MA (1996) Early improvement in intestinal function after isoperistaltic bowel lengthening. J Pediatr Surg 31(1):61–63 discussion 63–4
Wessel JJ, Kocoshis SA (2007) Nutritional management of infants with short bowel syndrome. Semin Perinatol 31(2):104–111. https://doi.org/10.1053/j.semperi.2007.02.009
Wester T, Borg H, Naji H, Stenström P, Westbacke G, Lilja HE (2014) Serial transverse enteroplasty to facilitate enteral autonomy in selected children with short bowel syndrome. Br J Surg 101(10):1329–1333. https://doi.org/10.1002/bjs.9583
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 © Springer-Verlag GmbH Deutschland
About this entry
Cite this entry
Lacher, M. (2018). Kurzdarmsyndrom bei Kindern. In: von Schweinitz, D., Ure, B. (eds) Kinderchirurgie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53390-1_50-1
Download citation
DOI: https://doi.org/10.1007/978-3-662-53390-1_50-1
Received:
Accepted:
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-53390-1
Online ISBN: 978-3-662-53390-1
eBook Packages: Springer Referenz Medizin