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Gastroösophagealer Reflux bei Kindern und Jugendlichen

  • Living reference work entry
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Part of the book series: Springer Reference Medizin ((SRM))

Zusammenfassung

Gastroösophagealer Reflux bedeutet ein Zurückfließen von Mageninhalt in den Ösophagus. Das Phänomen kann physiologischerweise erfolgen oder aber gravierende gesundheitliche Konsequenzen für den Patienten nach sich ziehen. In letzterem Falle spricht man von pathologischem gastroösophagealem Reflux. Dieser äußert sich unterschiedlich in den verschiedenen Altersgruppen. Einige kinderchirurgische Erkrankungen und angeborene Fehlbildungen prädisponieren zum Auftreten eines pathologischen gastroösophagealen Refluxes. Wenn konservative Maßnahmen die Symptome nicht unter Kontrolle bringen, ist eine chirurgische Therapie indiziert. Dabei gibt es verschiedene Ansätze, darunter zum einen eine partielle oder eine vollständige Fundoplikatio. Wenn die Indikation zur Fundoplikatio gestellt wird, sollte diese nach Möglichkeit laparoskopisch erfolgen. Der Eingriff geht mit einem nicht unerheblichen Rezidivrisiko einher. Allerdings kann unbehandelter gastroösophagealer Reflux langfristig ebenfalls zu schwerwiegenden Komplikationen wie einem Barrett-Ösophagus, einer Striktur oder zu einem Speiseröhrenkarzinom führen.

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Literatur

  • Alexander F, Wyllie R, Jirousek K et al (1997) Delayed gastric emptying affects outcome of Nissen fundoplication in neurologically impaired children. Surgery 122:690–697

    Article  PubMed  CAS  Google Scholar 

  • Arj A, Razavi Zade M (2016) Proton pump inhibitors use and change in bone mineral density. Int J Rheum Dis 19:864–868

    Article  PubMed  CAS  Google Scholar 

  • ASGE Technology Committee (2017) Endoscopic anti-reflux devices (with videos). Gastrointestinal Endosc 86: 931–948

    Google Scholar 

  • Ates F, Vaezi MF (2014) Insight into the relationship between gastroesophageal reflux disease and asthma. Gastroenterol Hepatol (N Y) 10:729–736

    Google Scholar 

  • Baerg J, Thorpe D, Gasior A et al (2015) Factors associated with mortality after Nissen fundoplication in children. Eur J Pediatr Surg 25:277–283

    PubMed  Google Scholar 

  • Barsness KA, St Peter SD, Holcomb GW 3rd et al (2009) Laparoscopic fundoplication after previous open abdominal operations in infants and children. J Laparoendosc Adv Surg Tech A 19(Suppl 1):S47–S49

    Article  PubMed  Google Scholar 

  • Blane CE, Klein MD, Drongowski RA et al (1986) Gastroesophageal reflux in children: is there a place for the upper gastrointestinal study? Gastrointest Radiol 11:346–348

    Article  PubMed  CAS  Google Scholar 

  • Boronat AC, Ferreira-Maia AP, Matijasevich A et al (2017) Epidemiology of functional gastrointestinal disorders in children and adolescents: a systematic review. World J Gastroenterol 23:3915–3927

    Article  PubMed  PubMed Central  Google Scholar 

  • Boyle MI, Jespersgaard C, Brøndum-Nielsen K et al (2015) Cornelia de Lange syndrome. Clin Genet 88:1–12

    Article  PubMed  CAS  Google Scholar 

  • Brar TS, Draganov PV, Yang D (2017) Endoluminal therapy for gastroesophageal reflux disease: in between the pill and the knife? Dig Dis Sci 62:16–25

    Article  PubMed  CAS  Google Scholar 

  • Briganti V, Oriolo L, Calisti A (2003) Reflux strictures of the oesophagus in children: personal experience with preoperative dilatation followed by anterior funduplication. Pediatr Surg Int 19:544–547

    Article  PubMed  Google Scholar 

  • Brown RA, Wynchank S, Rode H et al (1997) Is a gastric drainage procedure necessary at the time of antireflux surgery? J Pediatr Gastroenterol Nutr 25:377–380

    Article  PubMed  CAS  Google Scholar 

  • Bustorff-Silva J, Fonkalsrud EW, Perez CA et al (1999) Gastric emptying procedures decrease the risk of postoperative recurrent reflux in children with delayed gastric emptying. J Pediatr Surg 34:79–82

    Article  PubMed  CAS  Google Scholar 

  • Cabrera J, Davis M, Horn D et al (2011) Esophageal pH monitoring with the BRAVO capsule: experience in a single tertiary medical center. J Pediatr Gastroenterol Nutr 53:404–408

    PubMed  Google Scholar 

  • Caldaro T, Garganese MC, Torroni F et al (2011) Delayed gastric emptying and typical scintigraphic gastric curves in children with gastroesophageal reflux disease: could pyloromyotomy improve this condition? J Pediatr Surg 46:863–869

    Article  PubMed  Google Scholar 

  • Carr MM, Nguyen A, Nagy M et al (2000) Clinical presentation as a guide to the identification of GERD in children. Int J Pediatr Otorhinolaryngol 54:27–32

    Article  PubMed  CAS  Google Scholar 

  • Carroll AE, Garrison MM, Christakis DA (2002) A systematic review of nonpharmacological and nonsurgical therapies for gastroesophageal reflux in infants. Arch Pediatr Adolesc Med 156:109–113

    Article  PubMed  Google Scholar 

  • Caubet JC, Szajewska H, Shamir R et al (2016) Non-IgE-mediated gastrointestinal food allergies in children. Pediatr Allergy Immunol 28:6–17

    Article  PubMed  Google Scholar 

  • Chamond C, Morineau M, Gouizi G et al (2008) Preventive antireflux surgery in patients with congenital diaphragmatic hernia. World J Surg 32:2454–2458

    Article  PubMed  Google Scholar 

  • Chandrasekar S, Welch RJ, Watson H (2006) Congenital mixed hiatus hernia in a neonate. Arch Dis Child Fetal Neonatal Ed 91:F317

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cheng AW, Shaul DB, Lau ST et al (2014) Laparoscopic redo nissen fundoplication after previous open antireflux surgery in infants and children. J Laparoendosc Adv Surg Tech A 24:359–361

    Article  PubMed  Google Scholar 

  • Cohen S, Bueno de Mesquita M, Mimouni FB (2015) Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review. Br J Clin Pharmacol 80:200–208

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Collis JL (1957) An operation for hiatus hernia for short esophagus. J Thorac Surg 34:1957

    Google Scholar 

  • Corrado G, Cavaliere M, D’Eufemia P et al (2000) Sandifer’s syndrome in a breast-fed infant. Am J Perinatol 17:147–150

    Article  PubMed  CAS  Google Scholar 

  • Corvaglia L, Silvia Martini S, Aceti A et al (2013) Nonpharmacological management of gastroesophageal reflux in preterm infants. Biomed Res Int 2013:141967

    Article  PubMed  PubMed Central  Google Scholar 

  • Cribbs RK, Heiss KF, Clabby ML et al (2008) Gastric fundoplication is effective in promoting weight gain in children with severe congenital heart defects. J Pediatr Surg 43:283–289

    Article  PubMed  Google Scholar 

  • Cundy TP, Harling L, Marcus HJ et al (2014) Meta analysis of robot-assisted versus conventional laparoscopic fundoplication in children. J Pediatr Surg 49:646–652

    Article  PubMed  Google Scholar 

  • Dariel A, Rozé JC, Piloquet H et al (2010) Impact of prophylactic fundoplication on survival without growth disorder in left congenital diaphragmatic hernia requiring a patch repair. J Pediatr 157:688–690

    Article  PubMed  Google Scholar 

  • DeAntonio JH, Parrish DW, Rosati SF et al (2017) Laparoscopic gastroesophageal dissociation in neurologically impaired children with gastroesophageal reflux disease. J Pediatr Surg. pii: S0022-3468(17)30632-2. https://doi.org/10.1016/j.jpedsurg.2017.10.010. [Epub vor Druck]

  • Diamond IR, Mah K, Kim PC et al (2007) Predicting the need for fundoplication at the time of congenital diaphragmatic hernia repair. J Pediatr Surg 42:1066–1070

    Article  PubMed  Google Scholar 

  • Donoso F, Lilja HE (2017) Risk factors for anastomotic strictures after esophageal atresia repair: prophylactic proton pump inhibitors do not reduce the incidence of strictures. Eur J Pediatr Surg 27:50–55

    PubMed  Google Scholar 

  • Durkin ET, Schroth MK, Helin M et al (2008) Early laparoscopic fundoplication and gastrostomy in infants with spinal muscular atrophy type I. J Pediatr Surg 43:2031–2037

    Article  PubMed  Google Scholar 

  • Dziekiewicz MA, Banaszkiewicz A, Urzykowska A et al (2015) Gastroesophageal reflux disease in children with cystic fibrosis. Adv Exp Med Biol 873:1–7

    Article  PubMed  Google Scholar 

  • Ehrenpreis ED, Deepak P, Sifuentes H et al (2013) The metoclopramide black box warning for tardive dyskinesia: effect on clinical practice, adverse event reporting, and prescription drug lawsuits. Am J Gastroenterol 108:866–872

    Article  PubMed  CAS  Google Scholar 

  • Fass R, Cahn F, Scotti DJ et al (2017) Systematic review and meta-analysis of controlled and prospective cohort efficacy studies of endoscopic radiofrequency for treatment of gastroesophageal reflux disease. Surg Endosc 23. https://doi.org/10.1007/s00464-017-5431-2. [Epub vor Druck]

  • Fike FB, Mortellaro VE, Pettiford JN et al (2011) Diagnosis of gastroesophageal reflux disease in infants. Pediatr Surg Int 27:791–797

    Article  PubMed  Google Scholar 

  • Fonkalsrud EW, Ament ME (1996) Gastroesophageal reflux in childhood. Curr Probl Surg 33:1–70

    Article  PubMed  CAS  Google Scholar 

  • Fox D, Morrato E, Campagna EJ et al (2011) Outcomes of laparoscopic versus open fundoplication in children’s hospitals: 2005–2008. Pediatrics 127:872–880

    Article  PubMed  PubMed Central  Google Scholar 

  • Fraser JD, Aguayo P, Sharp SW et al (2009) The safety of laparoscopy in pediatric patients with ventriculoperitoneal shunts. J Laparoendosc Adv Surg Tech A 19:675–678

    Article  PubMed  Google Scholar 

  • Friedmacher F, Kroneis B, Huber-Zeyringer A et al (2017) Postoperative complications and functional outcome after esophageal atresia repair: results from longitudinal single-center follow-up. J Gastrointest Surg 21:927–935

    Article  PubMed  Google Scholar 

  • Fu LY, Moon RY (2012) Apparent life-threatening events: an update. Pediatr Rev 33:361–368

    Article  PubMed  Google Scholar 

  • Fyhn TJ, Knatten CK, Edwin B et al (2015) Randomized controlled trial of laparoscopic and open Nissen fundoplication in children. Ann Surg 261:1061–1067

    Article  PubMed  Google Scholar 

  • Ganz RA (2017) A modern magnetic implant for gastroesophageal reflux disease. Clin Gastroenterol Hepatol 15:1326–1337

    Article  PubMed  Google Scholar 

  • Garey CL, Laituri CA, Aguayo P et al (2011) Outcomes in children with hypoplastic left heart syndrome undergoing open fundoplication. J Pediatr Surg 46:859–862

    Article  PubMed  Google Scholar 

  • Garland JS, Alex CP, Johnston N et al (2014) Association between tracheal pepsin, a reliable marker of gastric aspiration, and head of bed elevation among ventilated neonates. J Neonatal Perinatal Med 7:185–192

    PubMed  CAS  Google Scholar 

  • Giuliano C, Wilhelm SM, Kale-Pradhan PB et al (2012) Are proton pump inhibitors associated with the development of community-acquired pneumonia? A meta-analysis. Expert Rev Clin Pharmacol 5:337–344

    Article  PubMed  CAS  Google Scholar 

  • Glen P, Chassé M, Doyle MA et al (2014) Partial versus complete fundoplication for the correction of pediatric GERD: a systematic review and meta-analysis. PLoS One 9:e112417

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gold BD (2006) Is gastroesophageal reflux disease really a life-long disease: do babies who regurgitate grow up to be adults with GERD complications? Am J Gastroenterol 101:641–644

    Article  PubMed  Google Scholar 

  • Goldani HA, Nunes DL, Ferreira CT (2012) Managing gastroesophageal reflux disease in children: the role of endoscopy. World J Gastrointest Endosc 4:339–346

    Article  PubMed  PubMed Central  Google Scholar 

  • Guner YS, Elliott S, Marr CC et al (2009) Anterior fundoplication at the time of congenital diaphragmatic hernia repair. Pediatr Surg Int 25:715–718

    Article  PubMed  PubMed Central  Google Scholar 

  • Hagander L, Muszynska C, Arnbjornsson E et al (2012) Prophylactic treatment with proton pump inhibitors in children operated on for oesophageal atresia. Eur J Pediatr Surg 22:139–142

    Article  PubMed  Google Scholar 

  • Heinrich M, Kain A, Bergmann F et al (2017) Parents reported reduced symptoms and improved satisfaction after fundoplication and their perceptions were an important outcome measure. Acta Paediatr 106:168–173

    Article  PubMed  Google Scholar 

  • Hendrickson RJ, Fenton L, Hall D et al (2003) Congenital paraesophageal hiatal hernia. J Am Coll Surg 196:483

    Article  PubMed  Google Scholar 

  • Hoffman I, Tertychnyy A, Ectors N et al (2007) Duodenogastro-esophageal reflux in children with refractory gastro-esophageal reflux disease. J Pediatr 151:307–311

    Article  PubMed  Google Scholar 

  • Horvath A, Dziechciarz P, Szajewska H (2008) The effect of thickened-feed interventions on gastroesophageal reflux in infants: systematic review and meta-analysis of randomized, controlled trials. Pediatrics 122:e1268–e1277

    Article  PubMed  Google Scholar 

  • Horwood JF, Calvert W, Mullassery D et al (2015) Simple fundoplication versus additional vagotomy and pyloroplasty in neurologically impaired children – a single centre experience. J Pediatr Surg 50:275–279

    Article  PubMed  Google Scholar 

  • Hsieh H, Frenette A, Michaud L et al (2017) Intestinal metaplasia of the esophagus in children with esophageal atresia. J Pediatr Gastroenterol Nutr 65:e1–e4

    Article  PubMed  Google Scholar 

  • Irwin S, Barmherzig R, Gelfand A (2017) Recurrent gastrointestinal disturbance: abdominal migraine and cyclic vomiting syndrome. Curr Neurol Neurosci Rep 17:21

    Article  PubMed  Google Scholar 

  • Johnson LF, Demeester TR (1974) Twenty-four-hour pH monitoring of the distal esophagus. A quantitative measure of gastroesophageal reflux. Am J Gastroenterol 62:325–332

    PubMed  CAS  Google Scholar 

  • Kawahara H, Tazuke Y, Soh H et al (2015) Causal relationship between delayed gastric emptying and gastroesophageal reflux in patients with neurological impairment. Pediatr Surg Int 31:917–923

    Article  PubMed  Google Scholar 

  • Khatami A, Allameh MM, Shahnazi M et al (2015) A comparison between gastroesophagheal ultrasonography vs. barium swallow in determining the pattern of gastroesophageal reflux in a pediatric population. Med Ultrason 17:22–27

    Article  PubMed  Google Scholar 

  • Kohn GP, Price RR, DeMeester SR (2013) Guidelines for the management of hiatal hernia. Surg Endosc 27:4409–4428

    Article  PubMed  Google Scholar 

  • Kuo B, Urma D (2006) Esophagus – anatomy and development. GI Motility online. https://doi.org/10.1038/gimo6. https://www.nature.com/gimo/contents/pt1/full/gimo6.html. Zugegriffen am 08.11.2017

  • Lall A, Morabito A, Bianchi A (2006) „Total Gastric Dissociation (TGD)“ in difficult clinical situations. Eur J Pediatr Surg 16:396–398

    Article  PubMed  CAS  Google Scholar 

  • Lansdale N, McNiff M, Morecroft J et al (2015) Long-term and ‚patient-reported‘ outcomes of total esophagogastric dissociation versus laparoscopic fundoplication for gastroesophageal reflux disease in the severely neurodisabled child. J Pediatr Surg 50:1828–1832

    Article  PubMed  Google Scholar 

  • Lewis PO, Litchfield JM, Tharp JL (2016) Risk and severity of hospital-acquired Clostridium difficile infection in patients taking proton pump inhibitors. Pharmacotherapy 36:986–993

    Article  PubMed  CAS  Google Scholar 

  • Liu DC, Flattmann GJ, Karam MT et al (2000) Laparoscopic fundoplication in children with previous abdominal surgery. J Pediatr Surg 35:334–337

    Article  PubMed  CAS  Google Scholar 

  • Liu DC, Somme S, Mavrelis PG et al (2005) Stretta as the initial antireflux procedure in children. J Pediatr Surg 40:148–151

    Article  PubMed  Google Scholar 

  • Liu YW, Wu JF, Chen HL et al (2016) The correlation between endoscopic reflux esophagitis and combined multichannel intraluminal impedance-pH monitoring in children. Pediatr Neonatol 57:385–389

    Article  PubMed  Google Scholar 

  • Lo WK, Chan WW (2013) Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis. Clin Gastroenterol Hepatol 11:483–490

    Article  PubMed  CAS  Google Scholar 

  • Lopez M, Kalfa N, Forgues D et al (2008) Laparoscopic redo fundoplication in children: failure causes and feasibility. J Pediatr Surg 43(10):1885–1890. https://doi.org/10.1016/j.jpedsurg.2008.05.032

    Article  PubMed  Google Scholar 

  • Lopez-Fernandez S, Hernandez F, Hernandez-Martin S et al (2014) Failed Nissen fundoplication in children: causes and management. Eur J Pediatr Surg 24:79–82

    PubMed  Google Scholar 

  • Lowe D, Hsu R (2017) Barrett metaplasia. https://www.ncbi.nlm.nih.gov/books/NBK459330/. Zugegriffen am 08.11.2017

  • Mandell GA, Wolfson PJ, Adkins ES et al (1999) Cost-effective imaging approach to the nonbilious vomiting infant. Pediatrics 103:1198–1202

    Article  PubMed  CAS  Google Scholar 

  • Marseglia L, Manti S, D’Angelo G et al (2015) Gastroesophageal reflux and congenital gastrointestinal malformations. World J Gastroenterol 21:8508–8515

    Article  PubMed  PubMed Central  Google Scholar 

  • Matsuo K, Palmer JB (2008) Anatomy and physiology of feeding and swallowing – normal and abnormal. Phys Med Rehabil Clin N Am 19:691–707

    Article  PubMed  PubMed Central  Google Scholar 

  • Mauritz FA, Blomberg BA, Stellato RK et al (2013) Complete versus partial fundoplication in children with gastroesophageal reflux disease: results of a systematic review and meta-analysis. J Gastrointest Surg 17:1883–1892

    Article  PubMed  CAS  Google Scholar 

  • Maxson RT, Harp S, Jackson RJ et al (1994) Delayed gastric emptying in neurologically impaired children with gastroesophageal reflux: the role of pyloroplasty. J Pediatr Surg 29:726–729

    Article  PubMed  CAS  Google Scholar 

  • Meyers WF, Roberts CC, Johnson DG et al (1985) Value of tests for evaluation of gastroesophageal reflux in children. J Pediatr Surg 20:515–520

    Article  PubMed  CAS  Google Scholar 

  • Mizuno M, Kobayashi M, Sasaki A et al (2012) Early experience with single-incision laparoscopic Nissen fundoplication for gastroesophageal reflux disease in patients with mental retardation via a gastrostomy site incision: report of five cases. Surg Today 42:601–604

    Article  PubMed  Google Scholar 

  • Monti MC, Borrelli P, Nosetti L et al (2017) Incidence of apparent life-threatening events and post-neonatal risk factors. Acta Paediatr 106:204–210

    Article  PubMed  Google Scholar 

  • Mortellaro VE, Chen MK, Pincus D et al (2009) Infectious risk to ventriculo-peritoneal shunts from gastrointestinal surgery in the pediatric population. J Pediatr Surg 44:1201–1204

    Article  PubMed  Google Scholar 

  • Muensterer OJ, Perger L, Hansen EN et al (2011) Single-incision pediatric endosurgical Nissen fundoplication. J Laparoendosc Adv Surg Tech A 21:641–645

    Article  PubMed  Google Scholar 

  • Muñoz JV, Herreros B, Sanchiz V et al (2003) Dental and periodontal lesions in patients with gastro-oesophageal reflux disease. Dig Liver Dis 35:461–467

    Article  PubMed  Google Scholar 

  • Murase N, Uchida H, Kaneko K et al (2015) Prophylactic effect of H2 blocker for anastomotic stricture after esophageal atresia repair. Pediatr Int 57:461–464

    Article  PubMed  CAS  Google Scholar 

  • Nakayama Y, Ida S (2017) Endoscopic findings of esophagogastric junction in children. Dig Endosc 29(Suppl 2):11–17

    Article  PubMed  Google Scholar 

  • Nowaczyk MJM (2013) Smith-Lemli-Opitz syndrome. In: Pagon RA, Adam MP, Ardinger HH et al (Hrsg) GeneReviews. University of Washington, Seattle, S 1993–2017

    Google Scholar 

  • Okuyama H, Urao M, Starr GA et al (1997) A comparison of the efficacy of pyloromyotomy and pyloroplasty in patients with gastroesophageal reflux and delayed gastric emptying. J Pediatr Surg 32:316–319

    Article  PubMed  CAS  Google Scholar 

  • Orenstein SR, Shalaby TM, Kelsey SF et al (2006) Natural history of infant reflux esophagitis: symptoms and morphometric histology during one year without pharmacotherapy. Am J Gastroenterol 101:628–640

    Article  PubMed  Google Scholar 

  • Ostlie DJ, St Peter SD, Snyder CL et al (2007) A financial analysis of pediatric laparoscopic versus open fundoplication. J Laparoendosc Adv Surg Tech A 17:493–496

    Article  PubMed  Google Scholar 

  • Putnam LR, Harting MT, Tsao K et al (2016) Congenital diaphragmatic hernia defect size and infant morbidity at discharge. Pediatrics 138. pii: e20162043

    Article  PubMed  Google Scholar 

  • Pyun JE, Choi DM, Lee JH et al (2015) Achalasia previously diagnosed as gastroesophageal reflux disease by relying on esophageal impedance-pH monitoring: use of high-resolution esophageal manometry in children. Pediatr Gastroenterol Hepatol Nutr 18:55–59

    Article  PubMed  PubMed Central  Google Scholar 

  • Reusens H, Matthyssens L, Vercauteren C et al (2017) Multicentre survey on the current surgical management of oesophageal atresia in Belgium and Luxembourg. J Pediatr Surg 52:239–246

    Article  PubMed  Google Scholar 

  • Rhee D, Zhang Y, Chang DC et al (2011) Population-based comparison of open vs laparoscopic esophagogastric fundoplication in children: application of the Agency for Healthcare Research and Quality pediatric quality indicators. J Pediatr Surg 46:648–654

    Article  PubMed  Google Scholar 

  • Robertson JO, Jarboe MD (2017) Long-term outcomes of transoral incisionless fundoplication in a high-risk pediatric population. J Laparoendosc Adv Surg Tech A. https://doi.org/10.1089/lap.2017.0257. [Epub vor Druck]

  • Rosen R, Rodriguez L, Nurko S (2016) Pediatric rumination subtypes: a study using high-resolution esophageal manometry with impedance. Neurogastroenterol Motil. https://doi.org/10.1111/nmo.12998. Epub 21.12.2016

  • Rossi V, Mazzola C, Leonelli L et al (2015) Long-term outcome and need of re-operation in gastro-esophageal reflux surgery in children. Pediatr Surg Int 32:277–283

    Article  PubMed  Google Scholar 

  • Rothenberg SS (2005) The first decade’s experience with laparoscopic Nissen fundoplication in infants and children. J Pediatr Surg 40:142–147

    Article  PubMed  Google Scholar 

  • Rothenberg SS, Chin A (2010) Laparoscopic Collis-Nissen for recurrent severe reflux in pediatric patients with esophageal atresia and recurrent hiatal hernia. J Laparoendosc Adv Surg Tech A 20:787–790

    Article  PubMed  Google Scholar 

  • Roussel JM, Pandit S (2017) Esophagitis, eosinophilic. https://www.ncbi.nlm.nih.gov/books/NBK459297/. Zugegriffen am 08.11.2017

  • Ru W, Wu P et al (2016) Laparoscopic versus open Nissen fundoplication in children: a systematic review and meta-analysis. J Pediatr Surg 51:1731–1736

    Article  PubMed  Google Scholar 

  • Salemme M, Villanacci V, Cengia G et al (2016) Intestinal metaplasia in Barrett’s oesophagus: an essential factor to predict the risk of dysplasia and cancer development. Dig Liver Dis 48:144–147

    Article  PubMed  Google Scholar 

  • Salvatore S, Hauser B, Vandemaele K et al (2005) Gastroesophageal reflux disease in infants: how much is predictable with questionnaires, pH-metry, endoscopy and histology? J Pediatr Gastroenterol Nutr 40:210–215

    Article  PubMed  Google Scholar 

  • Savino A, Cecamore C, Matronola MF et al (2012) US in the diagnosis of gastroesophageal reflux in children. Pediatr Radiol 42:515–524

    Article  PubMed  Google Scholar 

  • Schneider A, Gottrand F, Sfeir R et al (2012) Postoperative lower esophageal dilation in children following the performance of Nissen fundoplication. Eur J Pediatr Surg 22:399–403

    Article  PubMed  Google Scholar 

  • Shah SR, Jegapragasan M, Fox MD et al (2010) A review of laparoscopic Nissen fundoplication in children weighing less than 5 kg. J Pediatr Surg 45:1165–1168

    Article  PubMed  Google Scholar 

  • Shariff F, Kiely E, Curry J et al (2010) Outcome after laparoscopic fundoplication in children under 1 year. J Laparoendosc Adv Surg Tech A 20:661–664

    Article  PubMed  Google Scholar 

  • Shawyer AC, Pemberton J, Flageole H (2014) Post-operative management of esophageal atresia-tracheoesophageal fistula and gastroesophageal reflux: a Canadian Association of Pediatric Surgeons annual meeting survey. J Pediatr Surg 49:716–719

    Article  PubMed  Google Scholar 

  • Sheiko MA, Feinstein JA, Capocelli KE et al (2013) Diagnostic yield of EGD in children: a retrospective single-center study of 1000 cases. Gastrointest Endosc 78:47–54

    Article  PubMed  PubMed Central  Google Scholar 

  • Short HL, Braykov NP, Bost JE et al (2017) Variation in preoperative testing and antireflux surgery in infants. Pediatrics e20170536. https://doi.org/10.1542/peds.2017-0536. [Epub vor Druck]. PMID: 28752820

  • St Peter SD, Valusek PA, Calkins CM et al (2007) Use of esophagocrural sutures and minimal esophageal dissection reduces the incidence of postoperative transmigration of laparoscopic Nissen fundoplication wrap. J Pediatr Surg 42:25–29

    Article  PubMed  Google Scholar 

  • St Peter SD, Barnhart DC, Ostlie DJ et al (2011) Minimal vs extensive esophageal mobilization during laparoscopic fundoplication: a prospective randomized trial. J Pediatr Surg 46:163–168

    Article  PubMed  PubMed Central  Google Scholar 

  • Stenström P, Anderberg M, Börjesson A et al (2017) Prolonged use of proton pump inhibitors as stricture prophylaxis in infants with reconstructed esophageal atresia. Eur J Pediatr Surg 27:192–195

    Article  PubMed  Google Scholar 

  • Tannuri AC, Tannuri U, Mathias AL et al (2008) Gastroesophageal reflux disease in children: efficacy of Nissen fundoplication in treating digestive and respiratory symptoms. Experience of a single center. Dis Esophagus 21:746–750

    Article  PubMed  CAS  Google Scholar 

  • Thompson LD, McElhinney DB, Jue KL (1999) Gastroesophageal reflux after repair of atrioventricular septal defect in infants with trisomy 21: a comparison of medical and surgical therapy. J Pediatr Surg 34:1359–1363

    Article  PubMed  CAS  Google Scholar 

  • Tiboni SG, Patel Y, Lander AD et al (2011) Management of gastroesophageal reflux associated with malrotation in children. J Pediatr Surg 46:289–291

    Article  PubMed  Google Scholar 

  • Tieder JS, Bonkowsky JL, Etzel RA et al (2016) Brief resolved unexplained events (formerly apparent life-threatening events) and evaluation of lower-risk infants. Pediatrics 137. pii: e20160590

    Google Scholar 

  • Tolia V, Vandenplas Y (2009) Systematic review: the extra-oesophageal symptoms of gastro-oesophageal reflux disease in children. Aliment Pharmacol Ther 29:258–272

    Article  PubMed  CAS  Google Scholar 

  • US Food and Drug Administration (FDA) (2017) Consumer update: do not use infant sleep positioners due to the risk of suffocation. https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm227575.htm. Zugegriffen am 08.11.2017

  • Uslu Kızılkan N, Bozkurt MF, Saltık Temizel IN et al (2016) Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux. World J Gastroenterol 22:9595–9603

    Article  PubMed  PubMed Central  Google Scholar 

  • Uzun H, Alagoz D, Okur M et al (2012) Do gastrointestinal and respiratory signs and symptoms correlate with the severity of gastroesophageal reflux? BMC Gastroenterol 12:22

    Article  PubMed  PubMed Central  Google Scholar 

  • Valusek PA, St Peter SD, Tsao K et al (2007) The use of fundoplication for prevention of apparent life-threatening events. J Pediatr Surg 42:1022–1024

    Article  PubMed  Google Scholar 

  • Vandenplas Y (1999) Diagnosis and treatment of gastroesophageal reflux disease in infants and children. World J Gastroenterol 5:375–382

    Article  PubMed  Google Scholar 

  • Vergouwe FW, IJsselstijn H, Wijnen RM (2015) Screening and surveillance in esophageal atresia patients: current knowledge and future perspectives. Eur J Pediatr Surg 25:345–352

    Article  PubMed  Google Scholar 

  • Wang JH, Luo JY, Dong L et al (2004) Composite score of reflux symptoms in diagnosis of gastroesophageal reflux disease. World J Gastroenterol 10:3332–3335

    Article  PubMed  PubMed Central  Google Scholar 

  • Weesner KM, Rosenthal A (1983) Gastroesophageal reflux in association with congenital heart disease. Clin Pediatr (Phila) 22:424–426

    Article  CAS  Google Scholar 

  • Wild YK, Heyman MB, Vittinghoff E (2011) Gastroesophageal reflux is not associated with dental erosion in children. Gastroenterology 141:1605–1611

    Article  PubMed  Google Scholar 

  • World Gastroenterology Organisation Global Guidelines (2015) GERD – global perspective on gastroesophageal reflux disease. Update October 2015. http://www.worldgastroenterology.org/guidelines/global-guidelines/gastroesophageal-reflux-disease/gastroesophageal-reflux-disease-english. Zugegriffen am 08.11.2017

  • Yuan N, Wang CH, Trela A et al (2007) Laparoscopic Nissen fundoplication during gastrostomy tube placement and noninvasive ventilation may improve survival in type I and severe type II spinal muscular atrophy. J Child Neurol 22:727–731

    Article  PubMed  Google Scholar 

  • Yüksel F, Doğan M, Karataş D et al (2013) Clinical presentation of gastroesophageal reflux disease in children with chronic otitis media with effusion. J Craniofac Surg 24:380–383

    Article  PubMed  PubMed Central  Google Scholar 

  • Zani A, Eaton S, Hoellwarth ME et al (2014) International survey on the management of esophageal atresia. Eur J Pediatr Surg 24:3–8

    Article  PubMed  Google Scholar 

  • Zentilin P, Savarino V, Mastracci L et al (2005) Reassessment of the diagnostic value of histology in patients with GERD, using multiple biopsy sites and an appropriate control group. Am J Gastroenterol 100:2299–2306

    Article  PubMed  Google Scholar 

  • Zimbric G, Bonkowsky JL, Jackson WD et al (2012) Adverse outcomes associated with gastroesophageal reflux disease are rare following an apparent life-threatening event. J Hosp Med 7:476–481

    Article  PubMed  Google Scholar 

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Correspondence to Oliver J. Muensterer .

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Muensterer, O.J. (2018). Gastroösophagealer Reflux bei Kindern und Jugendlichen. In: von Schweinitz, D., Ure, B. (eds) Kinderchirurgie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53390-1_40-1

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