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Zytostatika-assoziierte Toxizitäten in der geriatrischen Onkologie

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Geriatrische Onkologie

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Zytostatika sind wichtige Bausteine für die Krebstherapie. Veränderte Organfunktionen, Komorbiditäten und Begleitmedikationen beeinflussen das Toxizitätsprofil von Zytostatika bei älteren Patienten. Die Studienlage zur Altersspezifität von Zytostatikatoxizität ist limitiert. Ältere Patienten sind in vielen klinischen Studien nicht repräsentativ vertreten. Für die meisten Zytostatika sind bei fehlenden signifikanten Einschränkungen der Organfunktionen keine altersspezifisch erhöhten Toxizitätsraten beschrieben. Letztlich obliegt es der klinischen Erfahrung eines interdisziplinären onkologischen Teams, eine Abwägung zwischen Toxizitätsrisiko mit drohender Lebensqualitätseinschränkung auf der einen und Effektivität einer Zytostatikatherapie auf der anderen Seite vorzunehmen. In diesem Kapitel werden Besonderheiten des geriatrischen Patienten im Hinblick auf die Toxizität von Zytostatika einschließlich moderner zielgerichteter Therapien dargelegt.

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  1. Klinik für Innere Medizin 2, Marien-Hospital, Pastor-Janßen-Str. 8-38, 46483, Wesel, Deutschland

    Henning Schulze-Bergkamen

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  1. II. Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany

    Matthias Ebert

  2. II. Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany

    Nicolai Härtel

  3. Klinik für Innere Medizin II, Universitätsklinikum Jena, Jena, Thüringen, Germany

    Ulrich Wedding

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  1. II. Medizinischen Klinik, Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland

    Matthias Ebert

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Schulze-Bergkamen, H. (2016). Zytostatika-assoziierte Toxizitäten in der geriatrischen Onkologie. In: Ebert, M., Härtel, N., Wedding, U. (eds) Geriatrische Onkologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49083-9_6-1

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