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Aging and Melanocytes Stimulating Cytokine Expressed by Keratinocyte and Fibroblast

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Textbook of Aging Skin
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Abstract

In the skin pigmentation, the actinic damage plays a major role, but the effect of chronologic cellular aging is also critical. Melanocytes, keratinocytes, and fibroblasts, whose paracrine effects on melanocytes play an important role in the epidermal pigmentation. The relationship of aging a cytokine secretion will be discussed in this chapter.

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References

  1. Leyden JJ. Clinical features of aging skin. Br J Dermatol. 1990;122(35):1–3.

    Article  PubMed  Google Scholar 

  2. Yada Y, Higuchi K, Imokawa G. Effect of endothelins on signal transduction and proliferation in human melanocytes. J Biol Chem. 1991;266:18352–7.

    CAS  PubMed  Google Scholar 

  3. Imokawa G, Yada Y, Miyagishi M. Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes. J Biol Chem. 1992;267:24675–80.

    CAS  PubMed  Google Scholar 

  4. Imokawa G, Miyagishi M, Yada Y. Endothelin-1 as a new melanogen: coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis. J Invest Dermatol. 1995;105:32–7.

    Article  CAS  PubMed  Google Scholar 

  5. Imokawa G, Yada Y, Kimura N, et al. Granulocyte/macrophage colony-stimulating factor is an intrinsic keratinocyte-derived growth factor for human melanocytes in UVA-induced melanosis. Biochem J. 1996;313:625–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Grabbe J, Welker P, Dippel E, et al. Stem cell factor, a novel cutaneous growth factor for mast cells and melanocytes. Arch Dermatol Res. 1994;161:78–84.

    Article  Google Scholar 

  7. Halaban R, Langdon R, Birchall N, et al. Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes. J Cell Biol. 1988;107:1611–9.

    Article  CAS  PubMed  Google Scholar 

  8. Puri N, van der Weel MB, de Wit FS, et al. Basic fibroblast growth factor promotes melanin synthesis by melanocytes. Arch Dermatol Res. 1996;288:633–5.

    Article  CAS  PubMed  Google Scholar 

  9. Scott G, Stoler M, Sarkar S, et al. Localization of basic fibroblast growth factor mRNA in melanocytic lesion by in situ hybridization. J Invest Dermatol. 1991;96:318–22.

    Article  CAS  PubMed  Google Scholar 

  10. Matsumoto K, Tajima H, Nakamura T. Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth. Biochem Biophys Res Commun. 1991;176:45–51.

    Article  CAS  PubMed  Google Scholar 

  11. Imokawa G, Yada Y, Morisaki N, et al. Characterization of keratinocyte- and fibroblast-derived mitogens for human melanocytes – their roles in stimulated cutaneous pigmentation. Melanogenesis and malignant melanoma. In: Hori Y, Hearing VJ, Nakayama J, editors. Biochemistry, cell biology, molecular biology, pathophysiology, diagnosis and treatment. Amsterdam: Elsevier; 1996. p. 35–48.

    Google Scholar 

  12. Matsumoto K, Okazaki H, Nakamura T. Up-regulation of Hepatocyte growth factor gene expression by interleukin-1 in human skin fibroblasts. Biochem Biophys Res Commun. 1992;188:235–43.

    Article  CAS  PubMed  Google Scholar 

  13. Maas-Szabowski N, Fusenig N. Interleukin-1-induced growth factor expression in postmitotic and resting fibroblasts. J Invest Dermatol. 1996;107:849–55.

    Article  CAS  PubMed  Google Scholar 

  14. Mildner M, Mlitz V, Gruber F, et al. Hepatocyte growth factor establishes autocrine and paracrine feedback loops for the protection of skin cells after UV irradiation. J Invest Dermatol. 2007;127:2637–44.

    Article  CAS  PubMed  Google Scholar 

  15. Kadono S, Manaka I, Kawashima M, et al. The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis. J Invest Dermatol. 2001;116:571–7.

    Article  CAS  PubMed  Google Scholar 

  16. Hattori H, Kawashima M, Ichikawa Y, et al. The epidermal stem cell factor is over-expressed in lentigo senilis: Implication for the mechanism of hyperpigmentation. J Invest Dermatol. 2004;122:1256–65.

    Article  CAS  PubMed  Google Scholar 

  17. Teraki E, Tajima S, Manaka I, et al. Role of endothelin-1 in hyperpigmentation in seborrheic keratosis. Br J Dermatol. 1996;135:918–23.

    Article  CAS  PubMed  Google Scholar 

  18. Okazaki M, Yoshimura K, Uchida G, et al. Correlation between age and the secretions of melanocyte-stimulating cytokines in cultured keratinocytes and fibroblasts. Br J Dermatol. 2005;153(s3):23–9.

    Article  CAS  PubMed  Google Scholar 

  19. Boyce ST, Ham RG. Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture. J Invest Dermatol. 1983;81.

    Google Scholar 

  20. Miyazaki M, Gohda E, Kaji K, et al. Increased Hepatocyte growth factor production by aging human fibroblasts mainly due to autocrine stimulation by interleukin-1. Biochem Biophys Res Commun. 1998;246:255–60.

    Article  CAS  PubMed  Google Scholar 

  21. Tadokoro T, Yamaguchi Y, Batzer J, et al. Mechanisms of skin tanning in different racial/ethnic groups in response to ultraviolet radiation. J Invest Dermatol. 2005;124:1326–32.

    Article  CAS  PubMed  Google Scholar 

  22. Wagner JK, Parra EJ, Norton HL. Skin responses to ultraviolet radiation: effects of constitutive pigmentation, sex, and ancestry. Pigment Cell Res. 2002;15:385–90.

    Article  PubMed  Google Scholar 

  23. Hachiya A, Kobayashi A, Ohuchi A, et al. The paracrine role of stem cell factor/c-kit signaling in the activation of human melanocytes in ultraviolet B-induced pigmentation. J Invest Dermatol. 2001;116:578–86.

    Article  CAS  PubMed  Google Scholar 

  24. Murphy JE, Robert C, Kupper TS. Interleukin-1 and Cutaneous inflammation: a crucial link between innate and acquired immunity. J Invest Dermatol. 2000;114:602–8.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Mutsumi Okazaki .

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Okazaki, M. (2017). Aging and Melanocytes Stimulating Cytokine Expressed by Keratinocyte and Fibroblast. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47398-6_38

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  • DOI: https://doi.org/10.1007/978-3-662-47398-6_38

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47397-9

  • Online ISBN: 978-3-662-47398-6

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