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Hyaluronan and the Process of Aging in Skin

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Textbook of Aging Skin

Abstract

Hyaluronan is a major component of the extracellular matrix of skin and important in the metabolism of both epidermis and dermis. Hyaluronan is responsible for hydration, nutrient exchange, and protects against free radical damage via a multitude of signaling pathways. It is also involved in basic biological processes such as cell renewal, differentiation, and motility. An overview is provided here that provides recent information, bringing up-to-date advances in hyaluronan and matrix biology with a particular emphasis on the process of aging in human skin. The differences between hyaluronan applied exogenously and that occurring naturally in the body are articulated. A brief history is also provided of various commercial hyaluronan-containing skin-care products, including topical applications, as injectable skin fillers, and in nanoparticle delivery systems.

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Authors and Affiliations

  1. The Department of Basic Biomedical Sciences, Touro College of Osteopathic Medicine, 10027, New York, NY, USA

    Diana Alyce Rivers & Robert Stern

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  1. Diana Alyce Rivers
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  2. Robert Stern
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Correspondence to Robert Stern .

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Editors and Affiliations

  1. Winton Hill Business Center, The Procter & Gamble Company , Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Margoshes-Miller Consulting, LLC, Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Rivers, D.A., Stern, R. (2017). Hyaluronan and the Process of Aging in Skin. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47398-6_22

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  • DOI: https://doi.org/10.1007/978-3-662-47398-6_22

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  • Print ISBN: 978-3-662-47397-9

  • Online ISBN: 978-3-662-47398-6

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