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Peroxisome Proliferator-Activated Receptors: Role in Skin Health and Appearance of Photoaged Skin

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Textbook of Aging Skin

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Abstract

The outermost layers of the epidermis are critical for providing a barrier against environmental factors. An intact epidermal barrier is critical for preventing moisture loss and maintaining the health. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. There is evidence that similar to other nuclear receptors, PPARs perform a significant role in skin homeostasis. The emphasis of this chapter will be the role of PPARs in the maintenance and improvement of human epidermal skin conditions.

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Acknowledgment

The authors would like to thank Susan Krein, Vickie Foy, Priya Vaidyanathan, and Robert Marriott for their contributions to this research.

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Authors and Affiliations

  1. Unilever Research and Development, Trumbull, CT, USA

    Stacy S. Hawkins, Jean Adamus & Helen Meldrum

  2. General Electric Company, Cardiff, UK

    William Shingleton

Authors
  1. Stacy S. Hawkins
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  2. William Shingleton
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  3. Jean Adamus
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  4. Helen Meldrum
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Corresponding author

Correspondence to Stacy S. Hawkins .

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Editors and Affiliations

  1. Winton Hill Business Center, The Procter & Gamble Company , Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Margoshes-Miller Consulting, LLC, Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Hawkins, S.S., Shingleton, W., Adamus, J., Meldrum, H. (2017). Peroxisome Proliferator-Activated Receptors: Role in Skin Health and Appearance of Photoaged Skin. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47398-6_21

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  • DOI: https://doi.org/10.1007/978-3-662-47398-6_21

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