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Neurotrophins and Skin Aging

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Textbook of Aging Skin

Abstract

Cutaneous aging is a complex biological phenomenon that consists of two superimposed components: intrinsic (true aging) and extrinsic (photoaging) aging. Intrinsic aging is largely genetically determined and represents an inevitable change attributable to the passage of time alone. The intrinsic rate of skin aging in any individual is influenced by personal and environmental factors (primarily to UV). Detailed mechanisms for each of intrinsic and extrinsic factors will be discussed in this chapter.

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References

  1. Botchkareva NV, Botchkarev VA, Welker P, Airaksinen M, Roth W, Suvanto P, Muller-Rover S, Hadshiew IM, Peters C, Paus R. New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control. Am J Pathol. 2000;156(3):1041–53.

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Botchkarev VA, Botchkareva NV, Peters EM, Paus R. Epithelial growth control by neurotrophins: leads and lessons from the hair follicle. Prog Brain Res. 2004;146:493–513.

    CAS  PubMed  Google Scholar 

  3. Adly MA, Assaf H, Hussein MR. Age-associated decrease of the nerve growth factor protein expression in the human skin: preliminary findings. J Dermatol Sci. 2006;42(3):268–71.

    CAS  PubMed  Google Scholar 

  4. Teng KK, Hempstead BL. Neurotrophins and their receptors: signaling trios in complex biological systems. Cell Mol Life Sci. 2004;61(1):35–48.

    CAS  PubMed  Google Scholar 

  5. Segal RA. Selectivity in neurotrophin signaling: theme and variations. Annu Rev Neurosci. 2003;26:299–330.

    CAS  PubMed  Google Scholar 

  6. Dechant G, Barde YA. The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system. Nat Neurosci. 2002;5(11):1131–6.

    CAS  PubMed  Google Scholar 

  7. Nykjaer A, Willnow TE, Petersen CM. p75NTR – live or let die. Curr Opin Neurobiol. 2005;15(1):49–57.

    CAS  PubMed  Google Scholar 

  8. Yaar M, Zhai S, Fine RE, Eisenhauer PB, Arble BL, Stewart KB, Gilchrest BA. Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling. J Biol Chem. 2002;277(10):7720–5.

    CAS  PubMed  Google Scholar 

  9. Peters EM, Hansen MG, Overall RW, Nakamura M, Pertile P, Klapp BF, Arck PC, Paus R. Control of human hair growth by neurotrophins: brain-derived neurotrophic factor inhibits hair shaft elongation, induces catagen, and stimulates follicular transforming growth factor beta2 expression. J Invest Dermatol. 2005;124(4):675–85.

    CAS  PubMed  Google Scholar 

  10. Peters EM, Hendrix S, Golz G, Klapp BF, Arck PC, Paus R. Nerve growth factor and its precursor differentially regulate hair cycle progression in mice. J Histochem Cytochem. 2006;54(3):275–88.

    CAS  PubMed  Google Scholar 

  11. Botchkareva NV, Botchkarev VA, Albers KM, Metz M, Paus R. Distinct roles for nerve growth factor and brain-derived neurotrophic factor in controlling the rate of hair follicle morphogenesis. J Invest Dermatol. 2000;114(2):314–20.

    CAS  PubMed  Google Scholar 

  12. Sariola H. The neurotrophic factors in non-neuronal tissues. Cell Mol Life Sci. 2001;58(8):1061–6.

    CAS  PubMed  Google Scholar 

  13. Ernfors P, Lee KF, Jaenisch R. Target derived and putative local actions of neurotrophins in the peripheral nervous system. Prog Brain Res. 1994;103:43–54.

    CAS  PubMed  Google Scholar 

  14. Yaar M, Grossman K, Eller M, Gilchrest BA. Evidence for nerve growth factor-mediated paracrine effects in human epidermis. J Cell Biol. 1991;115(3):821–8.

    CAS  PubMed  Google Scholar 

  15. Yaar M, Eller MS, DiBenedetto P, Reenstra WR, Zhai S, McQuaid T, Archambault M, Gilchrest BA. The trk family of receptors mediates nerve growth factor and neurotrophin-3 effects in melanocytes. J Clin Invest. 1994;94(4):1550–62.

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Botchkarev VA, Metz M, Botchkareva NV, Welker P, Lommatzsch M, Renz H, Paus R. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 act as “epitheliotrophins” in murine skin. Lab Invest. 1999;79(5):557–72.

    CAS  PubMed  Google Scholar 

  17. Adly MA, Assaf HA, Nada EA, Soliman M, Hussein M. Human scalp skin and hair follicles express neurotrophin-3 and its high-affinity receptor tyrosine kinase C, and show hair cycle-dependent alterations in expression. Br J Dermatol. 2005;153(3):514–20.

    CAS  PubMed  Google Scholar 

  18. Bonini S, Rasi G, Bracci-Laudiero ML, Procoli A, Aloe L. Nerve growth factor: neurotrophin or cytokine? Int Arch Allergy Immunol. 2003;131(2):80–4.

    CAS  PubMed  Google Scholar 

  19. Aloe L. Nerve growth factor, human skin ulcers and vascularization. Our experience. Prog Brain Res. 2004;146:515–22.

    CAS  PubMed  Google Scholar 

  20. Marco E, Di Marchisio PC, Bondanza S, Franzi AT, Cancedda R, De Luca M. Growth-regulated synthesis and secretion of biologically active nerve growth factor by human keratinocytes. J Biol Chem. 1991;266(32):21718–22.

    PubMed  Google Scholar 

  21. Adly MA, Assaf HA, Nada EA, Soliman M, Hussein M. Expression of nerve growth factor and its high-affinity receptor, tyrosine kinase A proteins, in the human scalp skin. J Cutan Pathol. 2006;33(8):559–68.

    PubMed  Google Scholar 

  22. Pincelli C, Sevignani C, Manfredini R, Grande A, Fantini F, Bracci-Laudiero L, Aloe L, Ferrari S, Cossarizza A, Giannetti A. Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes. J Invest Dermatol. 1994;103(1):13–8.

    CAS  PubMed  Google Scholar 

  23. Stefanato CM, Yaar M, Bhawan J, Phillips TJ, Kosmadaki MG, Botchkarev V, Gilchrest BA. Modulations of nerve growth factor and Bcl-2 in ultraviolet-irradiated human epidermis. J Cutan Pathol. 2003;30(6):351–7.

    PubMed  Google Scholar 

  24. Paus R, Luftl M, Czarnetzki BM. Nerve growth factor modulates keratinocyte proliferation in murine skin organ culture. Br J Dermatol. 1994;130(2):174–80.

    CAS  PubMed  Google Scholar 

  25. Marconi A, Vaschieri C, Zanoli S, Giannetti A, Pincelli C. Nerve growth factor protects human keratinocytes from ultraviolet-B-induced apoptosis. J Invest Dermatol. 1999;113(6):920–7.

    CAS  PubMed  Google Scholar 

  26. Marconi A, Terracina M, Fila C, Franchi J, Bonte F, Romagnoli G, Maurelli R, Failla CM, Dumas M, Pincelli C. Expression and function of neurotrophins and their receptors in cultured human keratinocytes. J Invest Dermatol. 2003;121(6):1515–21.

    CAS  PubMed  Google Scholar 

  27. Pincelli C. Nerve growth factor and keratinocytes: a role in psoriasis. Eur J Dermatol. 2000;10(2):85–90.

    CAS  PubMed  Google Scholar 

  28. Pincelli C, Haake AR, Benassi L, Grassilli E, Magnoni C, Ottani D, Polakowska R, Franceschi C, Giannetti A. Autocrine nerve growth factor protects human keratinocytes from apoptosis through its high affinity receptor (TRK): a role for BCL-2. J Invest Dermatol. 1997;109(6):757–64.

    CAS  PubMed  Google Scholar 

  29. Pincelli C, Yaar M. Nerve growth factor: its significance in cutaneous biology. J Investig Dermatol Symp Proc. 1997;2(1):31–6.

    CAS  PubMed  Google Scholar 

  30. Wehrli P, Viard I, Bullani R, Tschopp J, French LE. Death receptors in cutaneous biology and disease. J Invest Dermatol. 2000;115(2):141–8.

    CAS  PubMed  Google Scholar 

  31. Botchkarev VA, Botchkareva NV, Albers KM, Chen LH, Welker P, Paus R. A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression. FASEB J. 2000;14(13):1931–42.

    CAS  PubMed  Google Scholar 

  32. Adly MA, Assaf HA, Hussein MR. Expression pattern of p75 neurotrophin receptor protein in the human scalp skin and hair follice: hair cycle-dependent expression. J Am Acad Dermatol. 2009;60(1):99–109.

    PubMed  Google Scholar 

  33. Krygier S, Djakiew D. The neurotrophin receptor p75NTR is a tumor suppressor in human prostate cancer. Anticancer Res. 2001;21(6A):3749–55.

    CAS  PubMed  Google Scholar 

  34. Nakagawara A. Trk receptor tyrosine kinases: a bridge between cancer and neural development. Cancer Lett. 2001;169(2):107–14.

    CAS  PubMed  Google Scholar 

  35. Peacocke M, Yaar M, Mansur CP, Chao MV, Gilchrest BA. Induction of nerve growth factor receptors on cultured human melanocytes. Proc Natl Acad Sci U S A. 1988;85(14):5282–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Marco E, Di Mathor M, Bondanza S, Cutuli N, Marchisio PC, Cancedda R, De Luca M. Nerve growth factor binds to normal human keratinocytes through high and low affinity receptors and stimulates their growth by a novel autocrine loop. J Biol Chem. 1993;268(30):22838–46.

    PubMed  Google Scholar 

  37. Zhai S, Yaar M, Doyle SM, Gilchrest BA. Nerve growth factor rescues pigment cells from ultraviolet-induced apoptosis by upregulating BCL-2 levels. Exp Cell Res. 1996;224(2):335–43.

    CAS  PubMed  Google Scholar 

  38. Alleva E, Petruzzi S, Cirulli F, Aloe L. NGF regulatory role in stress and coping of rodents and humans. Pharmacol Biochem Behav. 1996;54(1):65–72.

    CAS  PubMed  Google Scholar 

  39. Alberch J, Perez-Navarro E, Arenas E, Marsal J. Involvement of nerve growth factor and its receptor in the regulation of the cholinergic function in aged rats. J Neurochem. 1991;57(5):1483–7.

    CAS  PubMed  Google Scholar 

  40. Garcia-Suarez O, Germana A, Hannestad J, Perez-Perez M, Esteban I, Naves FJ, Vega JA. Changes in the expression of the nerve growth factor receptors TrkA and p75LNGR in the rat thymus with ageing and increased nerve growth factor plasma levels. Cell Tissue Res. 2000;301(2):225–34.

    CAS  PubMed  Google Scholar 

  41. Backman C, Rose GM, Hoffer BJ, Henry MA, Bartus RT, Friden P, Granholm AC. Systemic administration of a nerve growth factor conjugate reverses age-related cognitive dysfunction and prevents cholinergic neuron atrophy. J Neurosci. 1996;16(17):5437–42.

    CAS  PubMed  Google Scholar 

  42. Amendola T, Aloe L. Developmental expression of nerve growth factor in the eye of rats affected by inherited retinopathy: correlative aspects with retinal structural degeneration. Arch Ital Biol. 2002;140(2):81–90.

    CAS  PubMed  Google Scholar 

  43. Aloe L. Rita Levi-Montalcini: the discovery of nerve growth factor and modern neurobiology. Trends Cell Biol. 2004;14(7):395–9.

    CAS  PubMed  Google Scholar 

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Correspondence to Mohamed A. Adly .

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Adly, M.A., Assaf, H., Hussein, M.R. (2017). Neurotrophins and Skin Aging. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47398-6_15

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  • DOI: https://doi.org/10.1007/978-3-662-47398-6_15

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47397-9

  • Online ISBN: 978-3-662-47398-6

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