Abstract
Skin aging is defined by two skin phenotypes: photoaging-induced hypertrophy and intrinsic aging-associated atrophy. Accumulating evidence suggests that impaired reactive oxygen species metabolism induces oxidative damage and causes age-related changes in the skin. To prevent the morphological changes from oxidative injuries, cells possess multiple antioxidative components, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase. Noble metal nanoparticles, such as platinum (Pt) and palladium (Pd) nanoparticles, are considered to function as antioxidants due to their strong catalytic activity. Pt nanoparticles show apparent SOD and catalase activity, while Pd nanoparticles exhibit weak activity. Interestingly, Pd nanoparticles prevent the oxidative deterioration of Pt nanoparticles, which helps to extend the SOD/catalase activity. A transdermal treatment with a mixture of Pt and Pd nanoparticles, called PAPLAL, completely reversed skin thinning associated with the normalization of lipid peroxidation in Sod1 −/− mice, which exhibited aging-like skin atrophy accompanied by the imbalance of extracellular matrix homeostasis. Furthermore, PAPLAL normalized the expression of extracellular matrix-related genes in the skin of Sod1 −/− mice. Other materials, such as vitamin C derivative, collagen peptides, and resveratrol, also attenuate age-related skin pathologies via the normalization of reactive oxygen species metabolism in the skin. These findings suggest that redox regulation in the skin is a beneficial strategy for the treatment of aging-related skin diseases caused by oxidative damage.
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Shibuya, S., Watanabe, K., Yokote, K., Shimizu, T. (2017). Platinum and Palladium Nanoparticles Regulate the Redox Balance and Protect Against Age-Related Skin Changes in Mice. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47398-6_120
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DOI: https://doi.org/10.1007/978-3-662-47398-6_120
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