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Proteoglycans in Skin Aging

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Abstract

Proteoglycans are ubiquitous macromolecules of extracellular matrix, cell surface, and some intracellular granules. They are composed of a glycoprotein core to which one or several glycosaminoglycan chains are attached by covalent linkage. More than 40 different genes encode proteoglycans. Most of them are expressed in skin cells. However, only some of the protein products have been confirmed to reside in skin.

Skin proteoglycans contribute to tissue hydration, resistance and resilience, molecular filtration. They also control cell behavior and cell–cell or cell–matrix interactions. Additionally, by their polyanionic properties, proteoglycans constitute the biological reservoir of many cytokines and growth factors. Such a diversity of functions supposes that any changes of their expression or structure during aging may perturb the tissue homeostasis significantly

In this chapter, we’ll review the different types of proteoglycans present in the skin and their main biological functions, with special interest to the alterations of these molecules during aging. The review will show that proteoglycans may play a major role in skin homeostasis and in its functional and architectural properties. Large areas remain, however, unknown at this time and many consequences on skin physiology have still to be investigated. Design of new experimental models, especially in vivo, will permit to better study the implication of proteoglycan alterations in the defects linked to skin aging.

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Authors and Affiliations

  1. Laboratoire de Biochimie, CNRS UMR 7369, Faculté de Médecine, Université de Reims-Champagne-Ardenne, 51 rue Cognacq Jay, 51095 Cedex, Reims, France

    François-Xavier Maquart, Stéphane Brézillon & Yanusz Wegrowski

  2. Centre National de la Recherche Scientifique, CNRS UMR 7369, Reims, France

    François-Xavier Maquart, Stéphane Brézillon & Yanusz Wegrowski

  3. Centre Hospitalier et Universitaire (CHU) de Reims, Reims, France

    François-Xavier Maquart

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  1. François-Xavier Maquart
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  2. Stéphane Brézillon
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  3. Yanusz Wegrowski
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Correspondence to François-Xavier Maquart .

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Editors and Affiliations

  1. Winton Hill Business Center, The Procter & Gamble Company , Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Margoshes-Miller Consulting, LLC, Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Maquart, FX., Brézillon, S., Wegrowski, Y. (2017). Proteoglycans in Skin Aging. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47398-6_11

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