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Erkrankungen des autonomen Nervensystems

  • Christina HaubrichEmail author
Living reference work entry
Part of the Springer Reference Medizin book series (SRM)

Zusammenfassung

Autonome Funktionsstörungen können das sympathische, parasympathische oder enterische Nervensystem isoliert oder in Kombination betreffen. Ursächlich hierfür sind Erkrankungen sowohl des peripheren als auch des zentralen Nervensystems. Dieses Kapitel gibt einen Überblick über die Verlaufsformen und Therapie autonomer Funktionsstörungen. Für den Einsatz zusatzdiagnostischer Verfahren wird ein Algorithmus empfohlen, der sich am klinischen Beschwerdebild orientiert. Sofern autoimmune, metabolische, infektiöse oder auch degenerative Erkrankungen nachweisbar sind, besteht die Möglichkeit, dass durch die Behandlung der Ursache eine Verbesserung der autonomen Nervenfunktionen erzielt werden kann.

Literatur

  1. Arbogast SD, Alshekhlee A, Hussain Z, McNeeley K, Chelimsky TC (2009) Hypotension unawareness in profound orthostatic hypotension. Am J Med 122(6):574–580CrossRefPubMedGoogle Scholar
  2. Beach TG et al (2010) Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol 119:689–702CrossRefPubMedPubMedCentralGoogle Scholar
  3. Blackett H, Walker R, Wood B (2009) Urinary dysfunction in Parkinson’s disease: a review. Parkinsonism Relat Disord 15:81–87CrossRefPubMedGoogle Scholar
  4. Bradbury S, Eggleston C (1925) Postural hypotension: a report of three cases. Am Heart J 1:73–86CrossRefGoogle Scholar
  5. Brignole M, Ungar A, Bartoletti A, Ponassi I, Lagi A, Mussi C, Ribani MA, Tava G, Disertori M, Quartieri F, Alboni P, Raviele A, Ammirati F, Scivales A, De Santo T, Evaluation of Guidelines in Syncope Study 2 ( EGSYS-2) GROUP (2006) Standardized-care pathway vs. usual management of syncope patients presenting as emergencies at general hospitals. Europace 8(8):644–650CrossRefPubMedGoogle Scholar
  6. Brignole M, Menozzi C, Moya A, Andresen D, Blanc JJ, Krahn AD, Wieling W, Beiras X, Deharo JC, Russo V, Tomaino M, Sutton R (2012) Pacemaker therapy in patients with neurally mediated syncope and documented asystole third international study on Syncope of Uncertain Etiology (ISSUE-3): a randomized trial. Circulation 125:2566–2571CrossRefPubMedGoogle Scholar
  7. Chaudhuri KR, Schapira AH (2009) Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol 8:464–474CrossRefPubMedGoogle Scholar
  8. Coon EA, Sletten DM, Suarez MD et al (2015) Clinical features and autonomic testing predict survival in multiple system atrophy. Brain 138(12):3623–3631CrossRefPubMedPubMedCentralGoogle Scholar
  9. Costantino G, Sun BC, Barbic F, Bossi I, Casazza G, Dipaola F, McDermott D, Quinn J, Reed MJ, Sheldon RS (2016) Syncope clinical management in the emergency department: a consensus from the first international workshop on syncope risk stratification in the emergency department. Eur Heart J 37(19):1493–1498CrossRefPubMedGoogle Scholar
  10. Dutsch M et al (2002) Small fiber dysfunction predominates in Fabry neuropathy. J Clin Neurophysiol 19:575–586CrossRefPubMedGoogle Scholar
  11. England JD, Gronseth GS, Franklin G, Carter GT, Kinsella LJ, Cohen JA, Asbury AK, Szigeti K, Lupski JR, Latov N, Lewis RA, Low PA, Fisher MA, Herrmann D, Howard JF, Lauria G, Miller RG, Polydefkis M, Sumner AJ (2009) Evaluation of distal symmetric polyneuropathy: the role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Muscle Nerve 39:106–115CrossRefPubMedGoogle Scholar
  12. Faber CG, Hoeijmakers JG, Ahn HS, Cheng X, Han C, Choi JS, Estacion M, Lauria G, Vanhoutte EK, Gerrits MM, Dib-Hajj S, Drenth JP, Waxman SG, Merkies IS (2012) Gain of function Naν1.7 mutations in idiopathic small fiber neuropathy. Ann Neurol 71(1):26–39CrossRefPubMedGoogle Scholar
  13. Flachenecker P (2007) Autonomic dysfunction in Guillain-Barré syndrome and multiple sclerosis. J Neurol 254(Suppl 2):II96–I101PubMedGoogle Scholar
  14. Iodice V et al (2009) Efficacy of immunotherapy in seropositive and seronegative putative autoimmune autonomic ganglionopathy. Neurology 72:2002–2008CrossRefPubMedPubMedCentralGoogle Scholar
  15. Kaplan SA, Te AE, Blaivas JG (1995) Urodynamic findings in patients with diabetic cystopathy. J Urol 153:342–344CrossRefPubMedGoogle Scholar
  16. Kaufmann H, Biaggioni I (2003) Autonomic failure in neurodegenerative disorders. Semin Neurol 23:351–363CrossRefPubMedGoogle Scholar
  17. Kimpinski K, Iodice V, Burton DD, Camilleri M, Mullan BP, Lipp A, Sandroni P, Gehrking TL, Sletten DM, Ahlskog JE, Fealey RD, Singer W, Low PA (2012) The role of autonomic testing in the differentiation of Parkinson's disease from multiple system atrophy. J Neurol Sci 317(1–2):92–96CrossRefPubMedPubMedCentralGoogle Scholar
  18. Koike H et al (2010) Clinicopathological features of acute autonomic and sensory neuropathy. Brain 133:2881–2896CrossRefPubMedGoogle Scholar
  19. Koike H, Watanabe H, Sobue G (2013) The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features. J Neurol Neurosurg Psychiatry 84:98–106CrossRefPubMedGoogle Scholar
  20. Kollensperger M et al (2010) Presentation, diagnosis, and management of multiple system atrophy in Europe: final analysis of the European multiple system atrophy registry. Mov Disord 25:2604–2612CrossRefPubMedGoogle Scholar
  21. Lende M van der, Surges R, Sander JW, Thijs RD (2016) Cardiac arrhythmias during or after epileptic seizures. J Neurol Neurosurg Psychiatry, 87(1):69–74Google Scholar
  22. Lucchinetti CF, Kimmel DW, Lennon VA (1998) Paraneoplastic and oncologic profiles of patients seropositive for type 1 antineuronal nuclear autoantibodies. Neurology 50:652–657CrossRefPubMedGoogle Scholar
  23. Maleki D, Locke III GR, Camilleri M; Zinsmeister R, Yawn BR, Leibson C, Melton III LJ (2000) Gastrointestinal Tract Symptoms Among Persons with Diabetes Mellitus in the Community. Arch Intern Med 160(18):2808–2816PubMedGoogle Scholar
  24. McKeon A, Lennon VA, Lachance DH, Fealey RD, Pittock SJ (2009) Ganglionic acetylcholine receptor autoantibody: oncological, neurological, and serological accompaniments. Arch Neurol 66:735–741PubMedPubMedCentralGoogle Scholar
  25. Moseley L, Birklein F, Baron R, Maihöfner C, Kingery WS, van Hilten JJ (2011) Clinical features and pathophysiology of complex regional pain syndrome. Lancet Neurol 10:637–648CrossRefPubMedPubMedCentralGoogle Scholar
  26. Palma JA, Fernandez-Cordon C, Coon EA et al (2015) Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis. Clin Auton Res 25(1):69–75CrossRefPubMedPubMedCentralGoogle Scholar
  27. Pavlakis PP et al (2011) Peripheral neuropathies in Sjögren syndrome: a new reappraisal. J Neurol Neurosurg Psychiatry 82:798–802CrossRefPubMedGoogle Scholar
  28. Said G, Planté-Bordeneuve V (2012) TTR-familial amyloid polyneuropathy – neurological aspects. Amyloid 19(Suppl. 1):25–27CrossRefPubMedGoogle Scholar
  29. Sharabi Y, Goldstein DS (2011) Mechanisms of orthostatic hypotension and supine hypertension in Parkinson disease. J Neurol Sci 310:123–128CrossRefPubMedPubMedCentralGoogle Scholar
  30. Shibao C, Lipsitz LA, Biaggioni I (2013) ASH position paper: evaluation and treatment of orthostatic hypotension. J Clin Hypertens (Greenwich) 15(3):147–153CrossRefGoogle Scholar
  31. Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, Bernardi L, Valensi P (2010) Toronto Diabetic Neuropathy Expert Group. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care 33(10):2285–2293Google Scholar
  32. Thaisetthawatkul P et al (2004) Autonomic dysfunction in dementia with Lewy bodies. Neurology 62:1804–1809CrossRefPubMedGoogle Scholar
  33. Treglia G et al (2011) Diagnostic performance of iodine-123-metaiodobenzylguanidine scintigraphy in differential diagnosis between Parkinson's disease and multiple-system atrophy: a systematic review and a meta-analysis. Clin Neurol Neurosurg 113:823–829CrossRefPubMedGoogle Scholar
  34. Vernino S et al (2000) Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N Engl J Med 343:847–855CrossRefPubMedGoogle Scholar
  35. Wang N, Gibbons CH, Lafo J, Freeman R (2013) α-Synuclein in cutaneous autonomic nerves. Neurology 81:1604–1610CrossRefPubMedPubMedCentralGoogle Scholar
  36. Ziegler D, Gries FA, Spuler M, Lessmann F (1992) The epidemiology of diabetic neuropathy. Diabetic Cardiovascular Autonomic Neuropathy Multicenter Study Group. J Diabetes Complicat 6:49–57CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Deutschland 2018

Authors and Affiliations

  1. 1.Facharzt-Zentrum DüsseldorfDüsseldorfDeutschland
  2. 2.Klinik für NeurologieUniversitätsklinikum AachenAachenDeutschland

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