The islets of Langerhansare endocrine cell cluster well ordered in lobules, of 0.3–0.7 mm in diameter, containing from 3,000 to 4,000 cells, and located mainly in the tail region of the pancreatic gland. Discovered in 1869, though representing only 2 % of the whole organ, they serve to coordinate the physiological control of the glycemic values in the blood. Five different hormone-secreting cell types constitute the islets’ cytoarchitecture: alpha cells producing glucagon, beta cells producing insulin and amylin, delta cells producing somatostatin, PP cells (gamma cells) producing the pancreatic polypeptide, and epsilon cells producing ghrelin. In human beings, the alpha and beta cells are in close relationship with each other. Representing nearly 90 % of the total islet cells, their secretive activity is modulated by the blood glucose levels: when low concentrations of sugar are detected, the islets respond with the glucagon secretion to induce the glucose release from the hepatic...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
David SW, Marchetti P (2014) Encapsulated islets for diabetes therapy: history, current progress, and critical issues requiring solution. Adv Drug Deliv Rev 67–68:35–73
Domìnguez-Bendala J, Pileggi A, Ricordi C (2013) Islet cell therapy and pancreatic stem cells, Chapter 70. In: Atala A, Lanza R (eds) Handbook of stem cells, 2nd edn. Academic, New York, pp 835–853
Patel T, Salvatori M, Hemal S et al (2014) Pancreatic islets regeneration: the bioengineering approach, Chapter 41. In: Orlando G, Lerut JP, Soker S, Stratta RJ (eds) Regenerative medicine applications in organ transplantation, 1st edn. Academic, New York, pp 599–607
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
De Bartolo, L., Messina, A. (2016). Langerhans Islet. In: Drioli, E., Giorno, L. (eds) Encyclopedia of Membranes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44324-8_713
Download citation
DOI: https://doi.org/10.1007/978-3-662-44324-8_713
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-44323-1
Online ISBN: 978-3-662-44324-8
eBook Packages: Chemistry and Materials ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics