Encyclopedia of Parasitology

2016 Edition
| Editors: Heinz Mehlhorn

Infection Dosis

Reference work entry
DOI: https://doi.org/10.1007/978-3-662-43978-4_3965

It is widely accepted that the entomological inoculation rate (= EIR) is significantly correlated with the introduction of a patent infection with Plasmodium falciparum and other parasitic species. However, the question arose: how many sporozoites are needed to establish a patent infection? With respect to P. vivax in humans, it was published that as few as 10 sporozoites can be sufficient to establish a patent infection, while volunteer infections with P. falciparum showed that bites of five mosquitoes bearing more than 10 sporozoites are required to lead to a successful infection. These findings would indicate that in the case of P. falciparum, a higher rate of EIR is needed to spread malaria in a given region. In other coccidian parasites (  Eimeria , Toxoplasma,   Sarcocystis ,   Isospora , Cryptosporidium, etc.), it is widely unknown how many oocysts are needed to establish a patent infection.

Further Reading

  1. Sinden RE et al (2012) The design and interpretation of laboratory assays measuring mosquito transmission of Plasmodium. Trends Parasitol 28:457–465CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany