Chemical Class
Macrocyclic lactone (16-membered macrocyclic lactone, avermectins).
Mode of Action
Glutamate-gated chloride channel modulator. Nematocidal Drugs, Ectoparasiticides: Antagonists and Modulators of Chloride Channels.
Ivermectin application increases the release of GABA (γ-aminobutyric acid) at the presynaptic nerve ending leading to the opening of the chloride ion channels and thus increasing the GABA binding at the motor neuron.
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Further Reading
Dourmishew AL et al (2005) Ivermectin: pharmacology and application in dermatology. Int J Dermatol 44:1981–1988
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Mehlhorn, H. (2016). Ivermectin. In: Mehlhorn, H. (eds) Encyclopedia of Parasitology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43978-4_1635
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DOI: https://doi.org/10.1007/978-3-662-43978-4_1635
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