Macrocyclic lactone (16-membered macrocyclic lactone, avermectins).
Mode of Action
Glutamate-gated chloride channel modulator. Nematocidal Drugs, Ectoparasiticides: Antagonists and Modulators of Chloride Channels.
Ivermectin application increases the release of GABA (γ-aminobutyric acid) at the presynaptic nerve ending leading to the opening of the chloride ion channels and thus increasing the GABA binding at the motor neuron.
- Dourmishew AL et al (2005) Ivermectin: pharmacology and application in dermatology. Int J Dermatol 44:1981–1988Google Scholar