Encyclopedia of Parasitology

2016 Edition
| Editors: Heinz Mehlhorn

Ivermectin

Reference work entry
DOI: https://doi.org/10.1007/978-3-662-43978-4_1635

Chemical Class

Macrocyclic lactone (16-membered macrocyclic lactone, avermectins).

Mode of Action

Glutamate-gated chloride channel modulator. Nematocidal Drugs,  Ectoparasiticides: Antagonists and Modulators of Chloride Channels.

Ivermectin application increases the release of GABA (γ-aminobutyric acid) at the presynaptic nerve ending leading to the opening of the chloride ion channels and thus increasing the GABA binding at the motor neuron.

Further Reading

  1. Dourmishew AL et al (2005) Ivermectin: pharmacology and application in dermatology. Int J Dermatol 44:1981–1988Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Institut für Zoomorphologie, Zellbiologie und ParasitologieHeinrich-Heine-UniversitätDüsseldorfGermany