Physiology of the Developing Kidney: Acid-Base Homeostasis and Its Disorders

  • Peter D. Yorgin
  • Elizabeth G. Ingulli
  • Robert H. Mak
Reference work entry

Abstract

The body is highly dependent on acid–base control by the kidneys, lungs, and buffer systems to provide a cellular environment suitable for normal health, growth, and development. The acid and alkali loads from ingesting food and fluid must be managed so that the extracellular hydrogen ion (H+) concentration is maintained within a very narrow range. There are serious consequences from acid–base perturbations. Patients with severe acidemia, high blood levels of H+, may have problems with hyperkalemia, increased susceptibility to cardiac dysrhythmias, osteopenia, recurrent nephrolithiasis, skeletal muscle atrophy, and growth retardation in children

Keywords

Aspirin Diarrhea Angiotensin Glutamine Glucocorticoid 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Peter D. Yorgin
    • 1
    • 2
  • Elizabeth G. Ingulli
    • 3
    • 4
    • 5
  • Robert H. Mak
    • 1
    • 2
  1. 1.Pediatric NephrologyUniversity of CaliforniaSan DiegoUSA
  2. 2.Pediatric Nephrology DivisionRady Children’s HospitalSan DiegoUSA
  3. 3.Department of PediatricsUniversity of CaliforniaSan DiegoUSA
  4. 4.Division of NephrologyRady Children’s Hospital San DiegoSan DiegoUSA
  5. 5.Kidney Transplant ProgramRady Children’s HospitalSan DiegoUSA

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