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Complement-Mediated Glomerular Injury in Children

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Abstract

The complement system comprises about 30–40 proteins, glycoproteins, and membrane receptors that are present in body fluids and on cell surfaces (Tables 1, 2, and 3). Nearly all the soluble proteins are produced by the liver, but most are also synthesized in other tissues, including cells of the myeloid lineage and renal cells. Complement is considered part of the immune system, as its main biological function is the lysis and removal of pathogens by opsonization. In the past decade, new studies have revealed a pivotal role of complement in immune surveillance, the generation of inflammation, the initiation of antibody production, and tissue repair [1–3].

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Acknowledgments

The authors are grateful to Lilan Varga and Eniko Barnucz for their helpful suggestions. Research in the author’s laboratories was supported by the following grants: Hungarian Scientific Research Fund of Hungary OTKA 100909 to GSR, and OTKA 100687, OTKA 110909 to ZP.

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Authors and Affiliations

  1. 3rd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary

    Zoltán Prohászka

  2. Division of Nephrology and Dialysis, Children’s Hospital Bambino Gesù-IRCCS, Rome, Italy

    Marina Vivarelli

  3. 1st Department of Pediatrics, Faculty of Medicine, Semmelweis University, Budapest, Hungary

    George S. Reusz

Authors
  1. Zoltán Prohászka
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  2. Marina Vivarelli
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  3. George S. Reusz
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Corresponding author

Correspondence to Zoltán Prohászka .

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Editors and Affiliations

  1. Department of Pediatrics, Medical College of Wisconsin, Children’s Research Institute, Children’s Hospital, Health System of Wisconsin, Milwaukee, Wisconsin, USA

    Ellis D. Avner

  2. Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

    William E. Harmon

  3. Service de Néphrologie Pédiatrique, Hôpital Necker-Enfants Malades, Université Paris-Descartes, Paris, France

    Patrick Niaudet

  4. Department of Pediatrics, Wakayama Medical University, Wakayama City, Japan

    Norishige Yoshikawa

  5. Division of Nephrology, Bambino Gesù Children’s Hospital – IRCCS, Rome, Italy

    Francesco Emma

  6. Division of Nephrology and Hypertension, The Heart Institute, Cincinnati Children’s Hospital Medical Center, College of Medicine, Cincinnati, Ohio, USA

    Stuart L. Goldstein

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Prohászka, Z., Vivarelli, M., Reusz, G.S. (2016). Complement-Mediated Glomerular Injury in Children. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein, S. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43596-0_26

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  • DOI: https://doi.org/10.1007/978-3-662-43596-0_26

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