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Basics of Clinical Investigation

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Pediatric Nephrology

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Abstract

How can we best evaluate, treat, and assess long-term risks for children with kidney disease? Who is at risk of developing end-stage renal disease (ESRD) in childhood or young adulthood? Clinicians are often faced with questions such as these with uncertain answers in the practice of pediatric nephrology. Parents ask, “Why did my child get this disease?” “What is the most effective method to treat this condition?” “What’s the prognosis of this condition in my child?” Frequently, these answers are not known, and these questions are the inspiration for high-quality clinical research. The first step in developing a valuable clinical study is determining whether the initial query can be translated into a good research question.

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Author information

Authors and Affiliations

  1. Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    Susan L. Furth

  2. Department of Pediatrics, John Hopkins University School of Medicine, Baltimore, MD, USA

    Jeffrey J. Fadrowski

Authors
  1. Susan L. Furth
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  2. Jeffrey J. Fadrowski
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Corresponding author

Correspondence to Susan L. Furth .

Editor information

Editors and Affiliations

  1. Department of Pediatrics, Medical College of Wisconsin, Children’s Research Institute, Children’s Hospital, Health System of Wisconsin, Milwaukee, Wisconsin, USA

    Ellis D. Avner

  2. Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

    William E. Harmon

  3. Service de Néphrologie Pédiatrique, Hôpital Necker-Enfants Malades, Université Paris-Descartes, Paris, France

    Patrick Niaudet

  4. Department of Pediatrics, Wakayama Medical University, Wakayama City, Japan

    Norishige Yoshikawa

  5. Division of Nephrology, Bambino Gesù Children’s Hospital – IRCCS, Rome, Italy

    Francesco Emma

  6. Division of Nephrology and Hypertension, The Heart Institute, Cincinnati Children’s Hospital Medical Center, College of Medicine, Cincinnati, Ohio, USA

    Stuart L. Goldstein

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© 2016 Springer-Verlag Berlin Heidelberg

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Furth, S.L., Fadrowski, J.J. (2016). Basics of Clinical Investigation. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein, S. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43596-0_15

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  • DOI: https://doi.org/10.1007/978-3-662-43596-0_15

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-43595-3

  • Online ISBN: 978-3-662-43596-0

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