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Arzneimittelinduzierte Leberschäden

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SpringerReference Innere Medizin

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1 Definition

Arzneimittelinduzierte Leberschäden („drug-induced liver injury“, DILI) bezeichnen alle durch Medikamente verursachten Schädigungen der Leber. Es schließt sowohl frei verkäufliche als auch rezeptpflichtige Medikamente ein. Die Leberschädigung kann hoch akut oder mit zeitlichem Abstand von einigen Wochen nach Einnahme eintreten. Die Schädigungen können von leichter und reversibler bis tödlicher Ausprägung sein. Da das Erkennen einer arzneimittelinduzierten Leberschädigung aufgrund des unspezifischen Beschwerdebildes und der zeitlichen Latenz sehr schwierig ist, ist ein hohes Maß an klinischer Aufmerksamkeit zur Diagnosestellung erforderlich.

Besondere Bedeutung gewinnt dieses Thema, da arzneimittelinduzierte Leberschäden die häufigste Ursache eines akuten Leberversagens in den Industrienationen sind (Ostapowicz et al. 2002). Ebenso sind sie der häufigste Grund von Fehlschlägen in der Arzneimittelentwicklung, von Rücknahme von Medikamenten aus dem Markt bzw....

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Literatur

  • Andrade RJ et al (2005) Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology 129(2):512–521

    Article  PubMed  Google Scholar 

  • Bénichou C (1990) Criteria of drug-induced liver disorders. Report of an international consensus meeting. J Hepatol 11(2):272–276

    Article  PubMed  Google Scholar 

  • Danan G, Benichou C (1993) Causality assessment of adverse reactions to drugs I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 46:1323–1330

    Article  CAS  PubMed  Google Scholar 

  • Froomes PR et al (1999) Comparative effects of oxygen supplementation on theophylline and acetaminophen clearance in human cirrhosis. Gastroenterology 116(4):915–920

    Article  CAS  PubMed  Google Scholar 

  • Hadem J et al (2012) Etiologies and outcomes of acute liver failure in Germany. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 10(6):664–669

    Google Scholar 

  • HepNet (2012) No Title. HepNet J, (Ausgabe 2, 6. Jahrgang), 14

    Google Scholar 

  • Kaplowitz N (2005) Idiosyncratic drug hepatotoxicity. Nature reviews. Drug Discov 4(6):489–499

    Article  CAS  Google Scholar 

  • Larrey D (2002) Epidemiology and individual susceptibility to adverse drug reactions affecting the liver. Semin Liver Dis 22(2):145–155

    Article  CAS  PubMed  Google Scholar 

  • Lee WM (2003a) Acute liver failure in the United States. Semin Liver Dis 23(3):217–226

    Article  CAS  PubMed  Google Scholar 

  • Lee WM (2003b) Drug-induced hepatotoxicity — NEJM. N Engl J Med 349:474–485

    Article  CAS  PubMed  Google Scholar 

  • Lee WM et al (2009) Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure. Gastroenterology 137(3):856–864, 864.e1

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Murray-Lyon IM et al (1976) Prognostic value of serum alpha-fetoprotein in fulminant hepatic failure including patients treated by charcoal haemoperfusion. Gut 17(8):576–580

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Ostapowicz G et al (2002) Results of a prospective study of acute liver failure at 17 Tertiary Care Centers in the United States. Ann Intern Med 137(12):947–954

    Article  PubMed  Google Scholar 

  • Sgro C et al (2002) Incidence of drug-induced hepatic injuries: a French population-based study. Hepatology (Baltimore, Md) 36(2):451–455

    Article  Google Scholar 

  • Shapiro MA, Lewis JH (2007) Causality assessment of drug-induced hepatotoxicity: promises and pitfalls. Clin Liver Dis 11(3):477–505

    Article  PubMed  Google Scholar 

  • Smilkstein MJ et al (1988) Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med 319(24):1557–1562

    Article  CAS  PubMed  Google Scholar 

  • Staedt U et al (1993) Effects of ornithine aspartate on plasma ammonia and plasma amino acids in patients with cirrhosis. A double-blind, randomized study using a four-fold crossover design. J Hepatol 19(3):424–430

    Article  CAS  PubMed  Google Scholar 

  • Stirnimann G, Kessebohm K (2010) Liver injury caused by drugs: an update. Swiss Med Wkly 140:w13080

    PubMed  Google Scholar 

  • Teschke R (2002) Liver damage caused by drugs. Deutsche medizinische Wochenschrift (1946) 127(38):1953–1957

    Article  CAS  Google Scholar 

  • Thummel KE et al (2000) Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults. Clin Pharmacol Ther 67(6):591–599

    Article  CAS  PubMed  Google Scholar 

  • Watkins PB, Seeff LB (2006) Drug-induced liver injury: summary of a single topic clinical research conference. Hepatology 43(3):618–631

    Article  PubMed  Google Scholar 

  • Whitehead MW, Hainsworth I, Kingham JG (2001) The causes of obvious jaundice in South West Wales: perceptions versus reality. Gut 48(3):409–413

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Medizinische Hochschule Hannover, Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Zentrum Innere Medizin, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland

    Christoph H­ner zu Siederdissen & Markus Cornberg

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  1. Christoph H­ner zu Siederdissen
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  2. Markus Cornberg
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Correspondence to Christoph H­ner zu Siederdissen .

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  1. Medizinische Klinik I, Universitätsklinikum Schleswig-Hoslstein, Campus Lübeck, Lübeck, Schleswig-Holstein, Germany

    Hendrik Lehnert

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H­ner zu Siederdissen, C., Cornberg, M. (2014). Arzneimittelinduzierte Leberschäden. In: Lehnert, H. (eds) SpringerReference Innere Medizin. SpringerReference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54676-1_151-1

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  • DOI: https://doi.org/10.1007/978-3-642-54676-1_151-1

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  • Online ISBN: 978-3-642-54676-1

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