Skip to main content

Bioactive Substances of Plant Origin

  • Reference work entry

Abstract

Plant secondary metabolites are rich sources of bioactive compounds eliciting many beneficial health effects in man and animals. Plant-based foods, including vegetables, fruits, grains, seeds, nuts, and legumes, may contain hundreds of different phytochemicals. Recently, research on phytochemicals suggests their possibility as an important source of therapeutic and preventive agents against diseases. The types of foods containing these bioactive components are those functional foods that can provide desirable health benefits beyond their natural properties when consumed in a regular and consistent manner through diet. Alternatively, dietary supplements can be supplied to consumers in a concentrated form to deliver a specific bioactive phytochemical or a group of phytochemicals. Usually, these nutraceutical ingredients are administered with higher doses than in normal food or in a medicinal form with the purpose of improving human health. This chapter highlights the four most common groups of plant-derived bioactive components, polyphenols, alkaloids, terpenes, and saponins, mainly focusing on their chemistry, sources, and biological functions.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   549.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Al-Sereitia MR, Abu-Amerb KM, Sena P (1999) Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. Indian J Exp Biol 37:124–131

    Google Scholar 

  • Amoo SO (2009) Micropropagation and medicinal properties of Barleria Greenii and Huernia Hystrix. Doctoral dissertation, University of KwaZulu-Natal, Pietermaritzburg

    Google Scholar 

  • Barone JJ, Roberts HR (1996) Caffeine consumption. Food Chem Toxicol 34(1):119–129

    Article  CAS  Google Scholar 

  • Bhat ZA, Kumar D, Shah MY (2011) Angelica archangelica Linn. is an angel on earth for the treatment of diseases. Int J Nutr Pharmacol Neurol Dis 1(1):36

    Article  Google Scholar 

  • Blumenthal M (2004) Bitter orange peel and synephrine. Part 1. Whole Foods 77–79

    Google Scholar 

  • Bomser J, Madhavi DL, Singletary K, Smith MAL (1996) In vitro anticancer activity of fruit extracts from Vaccinium species. Planta Med 62(03):212–216

    Article  CAS  Google Scholar 

  • Borriello SP, Setchell KDR, Axelson M, Lawson AM (1985) Production and metabolism of lignans by the human faecal flora. J Appl Bacteriol 58(1):37–43

    Article  CAS  Google Scholar 

  • Bravo L (1998) Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 56(11):317–333

    Article  CAS  Google Scholar 

  • Brown PN, Paley LA, Roman MC, Chan M (2008) Single-laboratory validation of a method for the detection and/or quantification of select alkaloids in goldenseal supplements and raw materials by reversed-phase high-performance liquid chromatography. Pharm Biol 46(1–2):135–144

    Article  CAS  Google Scholar 

  • Chen C, Wei T, Gao Z, Zhao B, Hou J, Xu H, Packer L (1999) Different effects of the constituents of EGb761 on apoptosis in rat cerebellar granule cells induced by hydroxyl radicals. IUBMB Life 47(3):397–405

    Article  CAS  Google Scholar 

  • Clifford MN (1999) Chlorogenic acids and other cinnamates – nature, occurrence and dietary burden. J Sci Food Agric 79(3):362–372

    Article  CAS  Google Scholar 

  • D’Archivio M, Filesi C, Di Benedetto R, Gargiulo R, Giovannini C, Masella R (2007) Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanita 43(4):348

    Google Scholar 

  • Dewick PM (2001) The mevalonate and deoxyxylulose phosphate pathways: terpenoids and steroids. In: Medicinal natural products: a biosynthetic approach, 2nd edn. Wiley, New York/Chichester, pp 167–289

    Chapter  Google Scholar 

  • Dorman HJD, Deans SG (2000) Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 88(2):308–316

    Article  CAS  Google Scholar 

  • Drewes SE, George J, Khan F (2003) Recent findings on natural products with erectile-dysfunction activity. Phytochemistry 62(7):1019–1025

    Article  CAS  Google Scholar 

  • Erlund I (2004) Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology. Nutr Res 24(10):851–874

    Article  CAS  Google Scholar 

  • Fernández-Mar MI, Mateos R, García-Parrilla MC, Puertas B, Cantos-Villar E (2012) Bioactive compounds in wine: resveratrol, hydroxytyrosol and melatonin: a review. Food Chem 130(4):797–813

    Article  Google Scholar 

  • Gallaher DD, Bunzel M (2012) Potential health benefits of wild rice and wild rice products: literature review. Report. Agriculture Utilization Research Institute, pp 1–23

    Google Scholar 

  • Glade MJ (1999) Food, nutrition, and the prevention of cancer: a global perspective. American Institute for Cancer Research/World Cancer Research Fund, American Institute for Cancer Research, 1997. Nutrition (Burbank, Los Angeles County, Calif) 15(6):523

    Article  CAS  Google Scholar 

  • Gopi C, Dhanaraju MD (2011) Synthesis, characterization and anti-microbial action of novel azo dye derived from 4-methyl 7-OH 8 nitro coumarin. J Pharm Res 4(4):1037–1038

    Google Scholar 

  • Gruenwald J, Freder J, Armbruester N (2010) Cinnamon and health. Crit Rev Food Sci Nutr 50(9):822–834

    Article  Google Scholar 

  • Haaz S, Fontaine KR, Cutter G, Limdi N, Perumean-Chaney S, Allison DB (2006) Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obes Rev 7(1):79–88

    Article  CAS  Google Scholar 

  • He J, Giusti MM (2010) Anthocyanins: natural colorants with health-promoting properties. Ann Rev Food Sci Technol 1:163–187

    Article  CAS  Google Scholar 

  • Heckman MA, Weil J, Mejia D, Gonzalez E (2010) Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. J Food Sci 75(3):R77–R87

    Article  CAS  Google Scholar 

  • Heydari M, Sadeghi M, Akhoundi M, Jamshidi A, Akhoundzadeh S, Ghafari NM, Ghazi Khansari M (2007) Evaluating the effects of Centella asiatica on spermatogenesis in rats. J Reprod Infertil 4(29):367–374

    Google Scholar 

  • Hodgson JM, Puddey IB, Beilin LJ, Mori TA, Croft KD (1998) Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans. J Nutr 128(4):728–732

    CAS  Google Scholar 

  • Hostettmann K, Marston A (2005) Saponins. Cambridge University Press, Cambridge

    Book  Google Scholar 

  • Howes MJR, Perry NS, Houghton PJ (2003) Plants with traditional uses and activities, relevant to the management of Alzheimer’s disease and other cognitive disorders. Phytother Res 17(1):1–18

    Article  CAS  Google Scholar 

  • Jacobson JS, Troxel AB, Evans J, Klaus L, Vahdat L, Kinne D, Grann VR (2001) Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J Clin Oncol 19(10):2739–2745

    Article  CAS  Google Scholar 

  • Jain PK, Joshi H (2012) Coumarin: chemical and pharmacological profile. J Appl Pharm Sci 02(06):236–240

    Google Scholar 

  • Jia L, Zhao Y (2009) Current evaluation of the millennium phytomedicine-ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations. Curr Med Chem 16(19):2475

    Article  CAS  Google Scholar 

  • Johnsson P (2004) Phenolic compounds in flaxseed. Licentiate thesis, Swedish University of Agricultural Sciences

    Google Scholar 

  • Kaur S, Das M (2011) Functional foods: an overview. Food Sci Biotechnol 20(4):861–875

    Article  Google Scholar 

  • Kaur H, Kaur G (2014) A critical appraisal of solubility enhancement techniques of polyphenols. J Pharm 2014:1–14

    Google Scholar 

  • Khadem S, Marles RJ (2010) Monocyclic phenolic acids; hydroxy- and polyhydroxybenzoic acids: occurrence and recent bioactivity studies. Molecules 15(11):7985–8005

    Article  CAS  Google Scholar 

  • Khom S, Baburin I, Timin E, Hohaus A, Trauner G, Kopp B, Hering S (2007) Valerenic acid potentiates and inhibits GABAA receptors: molecular mechanism and subunit specificity. Neuropharmacology 53(1):178–187

    Article  CAS  Google Scholar 

  • Kubo S, Ohkura Y, Mizoguchi Y, Matsui-Yuasa I, Otani S, Morisawa S, Kinoshita H, Takeda S, Aburada M, Hosoya E. (1992). Effect of Gomisin A (TJN-101) on liver regeneration. Planta medica, 58(06), 489–492.

    Article  CAS  Google Scholar 

  • Kuczkowski KM (2009) Caffeine in pregnancy. Arch Gynecol Obstet 280(5):695–698

    Article  CAS  Google Scholar 

  • Kumar D, Bhat ZA, Kumar V, Shah MY (2013) Coumarins from Angelica archangelica Linn. and their effects on anxiety-like behavior. Prog Neuro Psychopharmacol Biol Psychiatry 40:180–186

    Article  CAS  Google Scholar 

  • Kuo YC, Sun CM, Ou JC, Tsai WJ (1997) A tumor cell growth inhibitor from Polygonum hypoleucum Ohwi. Life Sci 61(23):2335–2344

    Article  CAS  Google Scholar 

  • Kushwaha K, O’Bryan CA, Babu D, Crandall PG, Chen P, Lee SO (2014) Human health benefits of isoflavones from soybeans. Agric Food Anal Bacteriol 4(2):122–142

    Google Scholar 

  • Lacy A, O’Kennedy R (2004) Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer. Curr Pharm Des 10(30):3797–3811

    Article  CAS  Google Scholar 

  • Lattanzio V, Kroon PA, Linsalata V, Cardinali A (2009) Globe artichoke: a functional food and source of nutraceutical ingredients. J Funct Foods 1(2):131–144

    Article  CAS  Google Scholar 

  • Lewis SE (2006) Recent advances in the chemistry of macroline, sarpagine and ajmaline-related indole alkaloids. Tetrahedron 62(37):8655–8681

    Article  CAS  Google Scholar 

  • Lim CG, Koffas MAG (2010) Bioavailability and recent advances in the bioactivity of flavonoid and stilbene compounds. Curr Org Chem 14(16):1727–1751

    Article  CAS  Google Scholar 

  • Lu Y, Chen DF (2009) Analysis of Schisandra chinensis and Schisandra sphenanthera. J Chromatogr A 1216(11):1980–1990

    Article  CAS  Google Scholar 

  • Mahadevan S, Park Y (2008) Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses. J Food Sci 73(1):R14–R19

    Article  CAS  Google Scholar 

  • Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L (2004) Polyphenols: food sources and bioavailability. Am J Clin Nutr 79(5):727–747

    CAS  Google Scholar 

  • Mangels AR, Holden JM, Beecher GR, Forman MR, Lanza E (1993) Carotenoid content of fruits and vegetables: an evaluation of analytic data. J Am Diet Assoc 93(3):284–296

    Article  CAS  Google Scholar 

  • Martínez MJA, Bermejo Benito P (2005) Biological activity of quinones. Stud Nat Prod Chem 30:303–366

    Article  Google Scholar 

  • Mateos-Martín ML, Fuguet E, Quero C, Pérez-Jiménez J, Torres JL (2012) New identification of proanthocyanidins in cinnamon (Cinnamomum zeylanicum L.) using MALDI-TOF/TOF mass spectrometry. Anal Bioanal Chem 402(3):1327–1336

    Article  Google Scholar 

  • Mishra S, Verma P (2013) Flaxseed- bioactive compounds and health significance. IOSR J Humanit Soc Sci 17(3):46–50

    Article  Google Scholar 

  • Mistrikova I, Vaverkova S (2006) Echinacea – chemical composition, immunostimulatory activities and uses. Thaiszia J Bot 16:11–26

    Google Scholar 

  • Mulinacci N, Prucher D, Peruzzi M, Romani A, Pinelli P, Giaccherini C, Vincieri FF (2004) Commercial and laboratory extracts from artichoke leaves: estimation of caffeoyl esters and flavonoidic compounds content. J Pharm Biomed Anal 34(2):349–357

    Article  CAS  Google Scholar 

  • Nestel PJ, Yamashita T, Sasahara T, Pomeroy S, Dart A, Komesaroff P, Abbey M (1997) Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscler Thromb Vasc Biol 17(12):3392–3398

    Article  CAS  Google Scholar 

  • Olson JA (1989) Biological actions of carotenoids. J Nutr 119(1):94–95

    CAS  Google Scholar 

  • Pavela R, Vrchotová N (2013) Insecticidal effect of furanocoumarins from fruits of Angelica archangelica L. against larvae Spodoptera littoralis Boisd. Ind Crop Prod 43:33–39

    Article  CAS  Google Scholar 

  • Reissig CJ, Strain EC, Griffiths RR (2009) Caffeinated energy drinks – a growing problem. Drug Alcohol Depend 99(1):1–10

    Article  CAS  Google Scholar 

  • Rodriguez EB, Flavier ME, Rodriguez-Amaya DB, Amaya-Farfán J (2006) Phytochemicals and functional foods. Current situation and prospect for developing countries. Segurança Alimentar e Nutricional Campinas 13(1):1–22

    Google Scholar 

  • Schalch W, Weber P (1994) Vitamins and carotenoids – a promising approach to reducing the risk of coronary heart disease, cancer and eye diseases. In: Free radicals in diagnostic medicine. Springer, New York, pp 335–350

    Chapter  Google Scholar 

  • Selvaraj Y, Chander MS (2013) Senna-its chemistry, distribution and pharmaceutical value. J Ind Inst Sci 60(8):179

    Google Scholar 

  • Setty AR, Sigal LH (2005) Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects. In: Seminars in arthritis and rheumatism, vol 34, no 6. WB Saunders, Philadelphia, pp 773–784

    Google Scholar 

  • Shahidi F, Naczk M (2003) Phenolics in food and nutraceuticals. CRC Press, Boca Raton

    Google Scholar 

  • Shahidi F, Naczk M (2004) Contribution of phenolic compounds to flavor and color characteristics of foods. In: Phenolics in food and nutraceuticals. CRC Press, Boca Raton, pp 443–463

    Google Scholar 

  • Shi J, Yu J, Pohorly JE, Kakuda Y (2003) Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6(4):291–299

    Article  CAS  Google Scholar 

  • Smolinski AT, Pestka JJ (2005) Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver. J Inflamm 2(1):6

    Article  Google Scholar 

  • Srivastava R, Shukla YN, Kumar S (1997) Chemistry and pharmacology of Centella asiatica: a review. J Med Aromat Plant 19(4):1049–1056

    CAS  Google Scholar 

  • Stohs SJ, Shara M (2007) A review of the safety and efficacy of citrus aurantium in weight management. In: Obesity: epidemiology, pathophysiology, and prevention. CRC Press, Boca Raton, pp 371–382

    Chapter  Google Scholar 

  • Teissedre PL, Frankel EN, Waterhouse AL, Peleg H, German JB (1996) Inhibition ofIn VitroHuman LDL Oxidation by Phenolic Antioxidants from Grapes and Wines. Journal of the Science of Food and Agriculture, 70(1), 55–61.

    Article  CAS  Google Scholar 

  • Trauner G, Khom S, Baburin I, Benedek B, Hering S, Kopp B (2008) Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. Planta Med 74(01):19–24

    Article  CAS  Google Scholar 

  • Tsao R (2010) Chemistry and biochemistry of dietary polyphenols. Nutrients 2(12):1231–1246

    Article  CAS  Google Scholar 

  • Tyler VE (1998) Importance of European phytomedicinals in the American market: an overview. In: Phytomedicines of Europe: chemistry and biological activity. American Chemical Society, Washington, DC, pp 2–12

    Chapter  Google Scholar 

  • Upton R (2001) Goldenseal root (Hydrastis canadensis): standards of analysis, quality control, and therapeutics. American Herbal Phramacopoeia, Santa Cruz, pp 1–37

    Google Scholar 

  • Vidal CM, Aguiar TR, Phansalkar R, McAlpine JB, Napolitano JG, Chen SN, Araújo LSN, Pauli GF, Bedran-Russo A (2014) Galloyl moieties enhance the dentin biomodification potential of plant-derived catechins. Acta Biomater 10(7):3288–3294

    Article  CAS  Google Scholar 

  • Wasserman L, Avigad S, Beery E, Nordenberg J, Fenig E (2002) The effect of aloe emodin on the proliferation of a new merkel carcinoma cell line. Am J Dermatopathol 24(1):17–22

    Article  Google Scholar 

  • Wink M, Schmeller T, Latz-Brüning B (1998) Modes of action of allelochemical alkaloids: interaction with neuroreceptors, DNA, and other molecular targets. J Chem Ecol 24(11):1881–1937

    Article  CAS  Google Scholar 

  • Woolf AD, Watson WA, Smolinske S, Litovitz T (2005) The severity of toxic reactions to ephedra: comparisons to other botanical products and national trends from 1993–2002. Clin Toxicol 43(5):347–355

    Article  CAS  Google Scholar 

  • Yang CS, Ju J, Lu G, Xiao H, Hao X, Sang S, Lambert JD (2008) Cancer prevention by tea and tea polyphenols. Asia Pac J Clin Nutr 17(Suppl 1):245

    CAS  Google Scholar 

  • Yildiz F (ed) (2010) Advances in food biochemistry. CRC Press, Boca Raton

    Google Scholar 

  • Yun TK (2001) Brief introduction of Panax ginseng C.A. Meyer. J Korean Med Sci 16(Suppl):S3–S5

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mingfu Wang .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Zhao, Y., Wu, Y., Wang, M. (2015). Bioactive Substances of Plant Origin. In: Cheung, P., Mehta, B. (eds) Handbook of Food Chemistry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36605-5_13

Download citation

Publish with us

Policies and ethics