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Omics in Toxicology

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Regulatory Toxicology

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Abstract

The tremendous progress in the development of new technologies in the areas of molecular biology and bioinformatics enables interrogation of cellular responses to toxicant treatment at a global molecular level, allowing evaluation of toxic effects in the context of molecular pathways.

The major techniques currently employed, especially transcriptomics, but also proteomics and metabolomics, are being used and further evaluated in investigational toxicology. Since they already have been shown to provide increased insight into molecular mechanisms of toxicological effects, such data have been submitted to regulatory authorities to support regulatory assessment of new compounds in few cases. Still, such data could be used more broadly for hazard identification and even risk assessment, which is now being supported by recent initiatives though precompetitive collaborations.

Dr. Hans-Juergen Ahr is retired

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Authors and Affiliations

  1. Investigational Toxicology, Bayer AG, Wuppertal, Germany

    Heidrun Ellinger-Ziegelbauer & Hans-Juergen Ahr

Authors
  1. Heidrun Ellinger-Ziegelbauer
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  2. Hans-Juergen Ahr
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Correspondence to Heidrun Ellinger-Ziegelbauer .

Editor information

Editors and Affiliations

  1. Universität München Inst. Pharmakologie und Toxikologie, München, Germany

    Franz-Xaver Reichl

  2. Tübingen, Germany

    Michael Schwenk

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Ellinger-Ziegelbauer, H., Ahr, HJ. (2020). Omics in Toxicology. In: Reichl, FX., Schwenk, M. (eds) Regulatory Toxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36206-4_40-2

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  • DOI: https://doi.org/10.1007/978-3-642-36206-4_40-2

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  • Print ISBN: 978-3-642-36206-4

  • Online ISBN: 978-3-642-36206-4

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