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Toxicokinetic Tests

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Regulatory Toxicology

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Abstract

Toxicokinetics is an integral component of toxicological studies in order to interrelate the administered dose with the associated effect. Pharmaco−/toxicokinetic tests are essential for judging absorption, bioavailability, and bioefficacy across routes, regimens, and species. In case substances are administered by inhalation, it provides a means to identify substance accumulation and clearance in the lung. Also in other subdisciplines such as oral and skin toxicology, toxicokinetics is important for the assessment of persistence and bioaccumulation. Toxicokinetics includes analyses of temporal change of concentration profiles of the parent substance, its metabolites, or degradation products. Accordingly, toxicokinetic data provide indispensable estimates for systemic and organ-specific substance burdens and contribute significantly to the interpretation of toxicological data and their significance for humans. Many examples, mainly for inhalation testing, are provided.

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References

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Recommended Reading

  • Pauluhn J (2014b) The metrics of MWCNT-induced pulmonary inflammation are dependent on the selected testing regimen. Regul Toxicol Pharmacol 68:343–352

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Authors and Affiliations

  1. Retired from Experimental Toxicology, Bayer HealthCare, Wuppertal, Germany

    Jürgen Pauluhn

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  1. Jürgen Pauluhn
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Correspondence to Jürgen Pauluhn .

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Editors and Affiliations

  1. Universität München Inst. Pharmakologie und Toxikologie, München, Germany

    Franz-Xaver Reichl

  2. Tübingen, Germany

    Michael Schwenk

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Pauluhn, J. (2021). Toxicokinetic Tests. In: Reichl, FX., Schwenk, M. (eds) Regulatory Toxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36206-4_38-2

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  • DOI: https://doi.org/10.1007/978-3-642-36206-4_38-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-36206-4

  • Online ISBN: 978-3-642-36206-4

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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