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References
Camerino DC, Tricarico DA, Desaphy J-F (2007) Ion channel pharmacology. Neurotherapeutics 4:184–198
Conn PJ, Christopoulos A, Lindsley CW (2009) Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders. Nat Rev Drug Discov 8:41–54
Dunlop J, Bowlby M, Peri R, Tawa G, LaRocque J, Soloveva V, Morin J (2008a) Ion channel screening. Comb Chem High Throughput Screen 11:514–522
Dunlop J, Bowlby M, Peri R, Vasilyev D, Arias R (2008b) High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology. Nat Rev Drug Discov 7:358–368
Galandrin S et al (2007) The evasive nature of drug efficacy: implications for drug discovery. Trends Pharmacol Sci 28:423–430
Grigoriadis DE, Hoare SR, Lechner SM, Slee DH, Williams JA (2009) Drugability of extracellular targets: discovery of small molecule drugs targeting allosteric, functional, and subunit-selective sites on GPCRs and ion channels. Neuropsychopharmacology 34:106–125
Heilker R, Wolff M, Tautermann CS, Bieler M (2009) G-protein-coupled receptor-focused drug discovery using a target class platform approach. Drug Discov Today 14:231–240
Milligan G (2003) Principles: extending the utility of [35S]GTPγS binding assays. Trends Pharmacol Sci 24:87–90
Minor LK (2008) Label-free cell-based functional assays. Comb Chem High Throughput Screen 11:573–580
Thomsen W, Frazer J, Unett D (2005) Functional assays for screening GPCR targets. Curr Opin Biotechnol 16:655–665
Waldhoer M, Fong J, Jones RM, Lunzer MM, Sharma SK, Kostenis E, Portoghese PS, Whistler JL (2005) A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proc Natl Acad Sci U S A 102:9050–9055
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Lavreysen, H., Atack, J. (2015). Receptors: Functional Assays. In: Stolerman, I.P., Price, L.H. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36172-2_208
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DOI: https://doi.org/10.1007/978-3-642-36172-2_208
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