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Polypoidal Choroidal Vasculopathy

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Encyclopedia of Ophthalmology

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Synonyms

Idiopathic polypoidal choroidal vasculopathy (PCV); Multiple recurrent serosanguineous retinal pigment epithelial detachments in Black women; Posterior uveal bleeding syndrome (PUBS)

Definition

Polypoidal choroidal vasculopathy (PCV) is a macular disorder characterized by recurrent hemorrhage within the retina and retinal pigment epithelium (RPE). It is characterized by the presence of choroidal vascular channels (also known as the branching vascular network, BVN) ending in polyp-like dilations in the peripapillary and macular area.

Etiology

The etiology is still unknown. There are similarities between the genetic predisposition to PCV and to wet AMD. For example, a functional SNP at the promoter of serine protease HTRA1 was associated with a tenfold increased risk of developing PCV and choroidal neovascularization in Asians. Common causative genes include complement factor H on chromosome 1q23–32, albeit with different SNPs: Y402H (for neovascular AMD); rs3753394, rs800292...

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References

  • Hirami Y et al (2007) Hemorrhagic complications after photodynamic therapy for polypoidal choroidal vasculopathy. Retina 27(3):335–341

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  • Koh A et al (2012) EVEREST study: efficacy and safety of verteporfin photodynamic therapy in combination with ranibizumab or alone versus ranibizumab monotherapy in patients with symptomatic macular polypoidal choroidal vasculopathy. Retina 32(8):1453–1464

    Article  CAS  PubMed  Google Scholar 

  • Koh AH et al (2013) Polypoidal choroidal vasculopathy: evidence-based guidelines for clinical diagnosis and treatment. Retina 33(4):686–716

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  • Yuzawa M, Mori R, Haruyama M (2003) A study of laser photocoagulation for polypoidal choroidal vasculopathy. Jpn J Ophthalmol 47(4):379–384

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Eye & Retina Surgeons, 1 Orchard Boulevard, Singapore, Singapore

    Adrian Koh

Authors
  1. Adrian Koh
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Corresponding author

Correspondence to Adrian Koh .

Editor information

Editors and Affiliations

  1. Dept of Ophthal & Optometry,AKH, Medical University of Wien Dept of Ophthal & Optometry,AKH, Wien, Austria

    Ursula Schmidt-Erfurth

  2. Department of Ophthalmology, Goethe University of Frankfurt am Main Department of Ophthalmology, Frankfurt am Main, Germany

    Thomas Kohnen

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© 2014 Springer-Verlag Berlin Heidelberg

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Koh, A. (2014). Polypoidal Choroidal Vasculopathy. In: Schmidt-Erfurth, U., Kohnen, T. (eds) Encyclopedia of Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35951-4_982-1

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  • DOI: https://doi.org/10.1007/978-3-642-35951-4_982-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-35951-4

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