Khodadoust Line

Synonyms

Corneal endothelial rejection line

Definition

Khodadoust line, named after Dr. Ali Asghar Khodadoust, consists of cellular infiltrates that aggregate on the endothelium as a distinct line, which may be observed during corneal allograft endothelial rejection. These inflammatory precipitates can be seen on the endothelial surface in fine precipitates, in random clumps, or in linear form – Khodadoust line. This line tends to migrate from the peripheral corneal to the central cornea and is typically associated with stromal edema overlying the area traversed by the endothelial rejection line. This line is often considered to be the hallmark of graft rejection. Commonly, endothelial rejection is accompanied by inflammatory cells in the anterior chamber; however, the anterior chamber reaction is usually less severe than expected given the extent of keratic precipitates present. Khodadoust line is also accompanied by corneal stromal thickening and edematous epithelium as endothelial...