Punctate Epithelial Defects/Erosions
A breakdown of healthy corneal epithelium resulting in pinpoint defects with positive fluorescein, lissamine green, or rose bengal staining seen via a slit-lamp examination.
Tear film instability, desiccation, or inflammatory changes of the cornea resulting in a breakdown of the healthy epithelium. Causes include infectious, allergic, neurologic, toxic, or autoimmune diseases. Inflammation from these diseases leads to a secondary tear deficiency that may then lead to further epithelial disruption.
PEE is a nonspecific sign that occurs in many disease processes, usually as a result of instability of the tear film. The location and pattern of the PEE are important to determine the causative agent.
A full medical history should be conducted targeting autoimmune disorders, infiltrative processes, infectious causes, neuropathic disorders, and endocrine dysfunction. During examination, one of the...