Superior Limbic Keratoconjunctivitis
SLK is a chronic noninfectious inflammatory disorder characterized by inflammation of the upper tarsal and bulbar conjunctiva. It was described by Frederick Theodore in 1963 as inflammation of tarsal and bulbar conjunctiva, punctate staining of the cornea and its adjacent conjunctiva, limbic proliferation, and presence of filaments limited to the superior limbus or upper fourth of the cornea.
Superior limbic keratoconjunctivitis typically affects women with a female-to-male ratio of 3:1, usually affecting ages 20–60 years with a mean age of 50. There are no reported familial cases but it did affect identical twins. SLK affects people of different ethnic backgrounds and geographical distributions and not related to specific climates.
The etiology of SLK is still to be determined as many studies were conducted and the causes are still unknown. Theories suspected a viral etiology but never have...
- Krachmer JH, Mannis MJ, Holland EJ (2011) Cornea, vol 1, 3rd edn. Mosby Elsevier, London, pp 623–627Google Scholar