Definition
Mucous membrane pemphigoid is a chronic inflammatory disease that affects mucous membranes of the eyes, gastrointestinal system, skin, and genitals. When the eyes are involved, the term ocular cicatricial pemphigoid (OCP) is used.
Etiology
OCP is thought to represent a cytotoxic, type II hypersensitivity where autoantibodies are directed against cell surface antigens such as bullous pemphigoid antigen II (BP 180), located in the epithelial basement membrane zone (Weisenthal 2013). When these autoantigens are activated in the eye, resultant inflammation and breakdown of the conjunctival surface occur: a process termed cicatrization. IL-1, TNF-alpha, and macrophage-colony stimulating factor are all found to be overexpressed in OCP (Weisenthal 2013). When severe or left untreated, OCP can result in ocular surface scarring and vision loss.
Clinical Presentation
Ocular Manifestations
Symptoms:
...
References
Foster, S et al (2013) Ocular ciccatricial pemphigoid. UpToDate
Krachmer J, Mannis M, Holland E (2005) Cornea. Expert consult, 2nd edn. Volume I. Elsevier Mosby, pp 683–689
Rosa RH Jr. (2013) Basic and clinical science course. Ophthalmic Pathology and Intraocular Tumors, pp 54–56
Weisenthal RW (2013) Basic and clinical science course. External disease and cornea, pp 198–203
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
Zaffos, J. (2014). Pemphigoid, Cicatricial. In: Schmidt-Erfurth, U., Kohnen, T. (eds) Encyclopedia of Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35951-4_917-1
Download citation
DOI: https://doi.org/10.1007/978-3-642-35951-4_917-1
Received:
Accepted:
Published:
Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-35951-4
eBook Packages: Springer Reference MedicineReference Module Medicine