Posterior Polymorphous Corneal Dystrophy
Endothelial corneal dystrophy.
Posterior polymorphous corneal dystrophy (PPCD) is an autosomal dominantly inherited corneal dystrophy. Three genetic loci – PPCD 1 through 3 – have been isolated to chromosomes 20, 1, and 10, respectively. Mutations in COL8A2 (collagen type VIII alpha 2) and ZEB1 (two-handed zinc-finger homeodomain transcription factor 8) are responsible for PPCD 2 and PPCD 3. The gene implicated for PPCD 1 has not been isolated.