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Carcinoma In Situ, of Conjunctiva

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Encyclopedia of Ophthalmology

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Synonyms

And dyskeratosis; Bowen’s disease; Conjunctival intraepithelial neoplasia (CIN); Conjunctival squamous dysplasia; Intraepithelial epithelioma

Definition

Defined by abnormal malignant appearing epithelial cells replacing the entire conjunctival stratified squamous epithelial layer. If these malignant appearing stratified squamous epithelial cells extend through the epithelial basement membrane and invade the substantia propria of the conjunctiva, it is characterized as invasive squamous cell carcinoma.

Basic Characteristics

The etiology of CIN is uncertain and possibly multifactorial. The lesion most commonly develops on exposed areas of the bulbar conjunctiva, at the nasal or temporal corneoscleral limbus. Risk factors include male sex, advanced age, cigarette smoking, light complexion, prolonged sunlight exposure, and conjunctival infection by human papillomaviruses 16 and 18. In patients with AIDS, these lesions may undergo rapid growth. Immunosuppressed states seem to have...

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References

  • Erie JC, Campbell RJ, Liesegang TJ (1986) Conjunctival and corneal intraepithelial and invasive neoplasia. Ophthalmology 93:176–183

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  • Karp CL, Moore JK, Rosa RH (2001) Treatment of conjunctival and corneal intraepithelial neoplasia with topical interferon α-2b. Ophthalmology 108:1093–1098

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  • Lee GA, Williams G, Hirst LW, Green AC (1994) Risk factors in the development of ocular surface epithelial dysplasia. Ophthalmology 101:360–364

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  • Shields CL, Naseripour M, Shields JA (2002) Topical mitomycin C for extensive, recurrent conjunctival-corneal squamous cell carcinoma. Am J Ophthalmol 133:601–606

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, University of Texas – Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA

    Eli B. Moses

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  1. Eli B. Moses
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Correspondence to Eli B. Moses .

Editor information

Editors and Affiliations

  1. Dept of Ophthal & Optometry,AKH, Medical University of Wien Dept of Ophthal & Optometry,AKH, Wien, Austria

    Ursula Schmidt-Erfurth

  2. Department of Ophthalmology, Goethe University of Frankfurt am Main Department of Ophthalmology, Frankfurt am Main, Germany

    Thomas Kohnen

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© 2014 Springer-Verlag Berlin Heidelberg

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Moses, E.B. (2014). Carcinoma In Situ, of Conjunctiva. In: Schmidt-Erfurth, U., Kohnen, T. (eds) Encyclopedia of Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35951-4_755-1

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  • DOI: https://doi.org/10.1007/978-3-642-35951-4_755-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-35951-4

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