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Pseudoexfoliation Syndrome

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Encyclopedia of Ophthalmology

Synonyms

PEX; Pseudoexfoliatio lentis ; PXF

Definition

Elastic microfibrillopathy as an ocular manifestation of a systemic disorder is characterized by the deposition of whitish material on and within the structures of the anterior eye segment and is frequently associated with severe chronic secondary open-angle glaucoma and cataract.

Histology

The hallmark of PEX syndrome is a pathologic production and accumulation of an abnormal fibrillar extracellular material in the anterior segment tissues. The characteristic PEX fibrils appear to be multifocally produced by various intraocular cell types including the preequatorial lens epithelium, nonpigmented ciliary epithelium, trabecular endothelium, corneal endothelium, vascular endothelial cells, and virtually all cell types of the iris (Naumann et al. 1998). Accordingly, clinical-histopathologic correlations focus on the involvement of the lens, the zonular apparatus, the ciliary body, the iris, the trabecular meshwork, and the cornea.

Immunohistochemistry...

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References

  • Naumann GOH, Schlötzer-Schrehardt U, Küchle M (1998) Pseudoexfoliation syndrome for the comprehensive ophthalmologist: intraocular and systemic manifestations historical image. Ophthalmology 105(6):951–968

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  • Schlötzer-Schrehardt U (2009) Molecular pathology of pseudoexfoliation syndrome/glaucoma – new insights from LOXL1 gene associations. Exp Eye Res 88(4):776–785

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  • Schlötzer-Schrehardt U, Naumann GOH (2006) Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalmol 141(5):921–937

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  • Yanoff M, Duker JS (2009) Ophthalmology 3rd edition expert consult premium edition: enhanced online features and print. Mosby/Elsevier, London, pp 1172–1174

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Ludwig-Maximilians University, 80336, Munich, Germany

    Daniel Kook

  2. Department of Ophthalmology, Goethe-Universität Frankfurt/Main, 60590, Frankfurt/Main, Germany

    Thomas Kohnen

Authors
  1. Daniel Kook
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  2. Thomas Kohnen
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Corresponding author

Correspondence to Daniel Kook .

Editor information

Editors and Affiliations

  1. Dept of Ophthal & Optometry,AKH, Medical University of Wien Dept of Ophthal & Optometry,AKH, Wien, Austria

    Ursula Schmidt-Erfurth

  2. Department of Ophthalmology, Goethe University of Frankfurt am Main Department of Ophthalmology, Frankfurt am Main, Germany

    Thomas Kohnen

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© 2015 Springer-Verlag Berlin Heidelberg

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Kook, D., Kohnen, T. (2015). Pseudoexfoliation Syndrome. In: Schmidt-Erfurth, U., Kohnen, T. (eds) Encyclopedia of Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35951-4_493-2

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  • DOI: https://doi.org/10.1007/978-3-642-35951-4_493-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-35951-4

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