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Encyclopedia of Ophthalmology pp 1–4Cite as

Eales’ Disease

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Synonyms

Presumed tuberculous retinal periphlebitis

Definition

Eales’ disease is an uncommon, idiopathic inflammatory retinal vasculopathy that mainly affects the peripheral retina of otherwise healthy young adults in their second to fourth decade of life. The disease was first described in 1880–1882 by Henry Eales as a noninflammatory condition in young healthy male patients who presented with recurrent vitreous retinal hemorrhages and epistaxis. Subsequently, the condition has been redefined as a primarily inflammatory condition (Biswas et al. 2002).

The disease is characterized by an obliterative, progressive, peripheral retinal vasculitis, predominately periphlebitis that can lead to large areas of peripheral retinal non-perfusion, severe retinal ischemia, and neovascularization, resulting in repeat vitreous hemorrhages with or without retinal detachment. In some patients there are associated retinitis and vitritis, but in others there is very little or no inflammation.

Etiology

Eal...

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References

  • Biswas J, Sharma T, Gopal L, Madhavan HN, Sulochana KN, Ramakrishnan S (2002) Eales disease-an update. Surv Ophthalmol 47:197–214

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  • Biswas J, Ravi RK, Naryanasamy A, Kulandai LT, Madhavan HN (2013) Eales’ disease-current concepts in diagnosis and management. J Ophthalmic Inflamm Infect 3:11

    Article  PubMed  PubMed Central  Google Scholar 

  • Dehghan MH, Ahmadieh H, Soheilian M, Azarmina M, Mashayekhi A, Naghibozakerin J (2005) Therapeutic effects of laser photocoagulation and/or vitrectomy in Eales’ disease. Eur J Ophthalmol 15(3):379–383

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  • Gadkari SS, Kamdar PA, Jehangir RP, Shah NA, Adrianwala SD (1992) Pars plana vitrectomy vitreous haemorrhage due to Eales Disease. Indian J Ophthalmol 40:35–37

    CAS  PubMed  Google Scholar 

  • Gopal L, Abraham C (1985) Efficacy of photocoagulation in Eales’ disease. Trans Asia-Pacific Acad 10:689

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Institute of Ophthalmology, University College London; Moorfields Eye Hospital, London, UK

    Lazha Sharief, Oren Yovel, Abeir Baltmr, Sue Lightman & Oren Tomkins-Netzer

  2. Department of Clinical Ophthalmology, UCL Institute of Ophthalmology (IO), 256 Gray’s Inn Road, King’s Cross, London, WC1X 8LD, UK

    Sue Lightman

Authors
  1. Lazha Sharief
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  2. Oren Yovel
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  3. Abeir Baltmr
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  4. Sue Lightman
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  5. Oren Tomkins-Netzer
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Corresponding author

Correspondence to Lazha Sharief .

Editor information

Editors and Affiliations

  1. Dept of Ophthal & Optometry,AKH, Medical University of Wien Dept of Ophthal & Optometry,AKH, Wien, Austria

    Ursula Schmidt-Erfurth

  2. Department of Ophthalmology, Goethe University of Frankfurt am Main Department of Ophthalmology, Frankfurt am Main, Germany

    Thomas Kohnen

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© 2015 Springer-Verlag Berlin Heidelberg

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Sharief, L., Yovel, O., Baltmr, A., Lightman, S., Tomkins-Netzer, O. (2015). Eales’ Disease. In: Schmidt-Erfurth, U., Kohnen, T. (eds) Encyclopedia of Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35951-4_1063-1

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  • DOI: https://doi.org/10.1007/978-3-642-35951-4_1063-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-35951-4

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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