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Ectasia, Retinal

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Encyclopedia of Ophthalmology

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Synonyms

Choroidal coloboma; Chorioretinal coloboma; Fundus coloboma; Macular coloboma; Retinal coloboma; Retinochoroidal coloboma

Definition

A congenital defect, characterized by the absence of normal retina, retinal pigment epithelium, and choroid.

Etiology

Congenital ocular colobomata are caused by impaired embryogenesis. During embryogenesis, at around day 30 of gestation, the ventral surface of the optic vesicle and stalk invaginates leading to the formation of a double-layered optic cup. This invagination gives rise to the optic fissure, allowing blood vessels from the vascular mesoderm to enter the developing eye. Fusion of the edges of this fissure starts centrally around day 33 of gestation and proceeds anteriorly toward the rim of the optic cup and posteriorly along the optic stalk, with completion by 7 weeks. Failure of part of the fetal fissure to close results in the clinical entity recognized as coloboma which may affect one or more areas of the eye including the eyelid,...

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References

  • Barnard S (2012) Bilateral chorioretinal coloboma discovered with ultra-wide field retinal imaging. J Optom 5(3):150–154

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  • Gregory-Evans CY et al (2004) Ocular coloboma: a reassessment in the age of molecular neuroscience. J Med Genet 41(12):881–891

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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  • Schubert HD et al (2005) Structural organization of choroidal colobomas of young and adult patients and mechanism of retinal detachment. Trans Am Ophthalmol Soc 103:457–472

    PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Rambam Health Campus, Haifa, Israel

    Shiri Soudry & Michael Mimouni

  2. Ruth and Bruce Rappaport Faculty of Medicine, Technion, Hazrot Haikarim 10, 253, 30300, Haifa, Israel

    Shiri Soudry & Michael Mimouni

Authors
  1. Shiri Soudry
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  2. Michael Mimouni
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Corresponding author

Correspondence to Shiri Soudry .

Editor information

Editors and Affiliations

  1. Dept of Ophthal & Optometry,AKH, Medical University of Wien Dept of Ophthal & Optometry,AKH, Wien, Austria

    Ursula Schmidt-Erfurth

  2. Department of Ophthalmology, Goethe University of Frankfurt am Main Department of Ophthalmology, Frankfurt am Main, Germany

    Thomas Kohnen

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© 2014 Springer-Verlag Berlin Heidelberg

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Soudry, S., Mimouni, M. (2014). Ectasia, Retinal. In: Schmidt-Erfurth, U., Kohnen, T. (eds) Encyclopedia of Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35951-4_1009-1

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  • DOI: https://doi.org/10.1007/978-3-642-35951-4_1009-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-35951-4

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