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The Aspergillus species is a member of the deuteromycetes fungi. They are highly aerobic and are found in the air we breathe. It is commonly involved in pulmonary and paranasal sinus infections, and while it occasionally occurs in immunocompetent patients and can lead to orbital involvement and keratitis, it is most commonly related to immunocompromised patients and is the second most common cause of endogenous endophthalmitis following the Candida species. Risk factors for developing Aspergillus infection include neutropenic patients, following solid organ transplantation in those taking systemic corticosteroids or immunosuppression drugs, diabetes mellitus patients, cystic fibrosis patients, intravenous drug users, or those with an impaired immune system, such as those with human immunodeficiency virus infections. Aspergillus flavus, A. fumigatus, A. niger, A. terreus, A. glaucus, and A. nidulanshave all been reported to cause...
Further Reading
Hoenigl M, Krause R (2013) Antifungal therapy of aspergillosis of the central nervous system and aspergillus endophthalmitis. Curr Pharm Des 19(20):3648–3668
Chhablani J (2011) Fungal endophthalmitis. Expert Rev Anti Infect Ther 9(12):1191–1201
Sallam A, Jayakumar S, Lightman S (2008) Intraocular delivery of anti-infective durgs-bacterial, viral, fungal and parasitic. Recent Pat Antiinfect Drug Discov 3(1):53–63
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Lightman, S. (2014). Aspergillus (Aspergillosis), Endogenous Endophthalmitis. In: Schmidt-Erfurth, U., Kohnen, T. (eds) Encyclopedia of Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35951-4_1003-1
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DOI: https://doi.org/10.1007/978-3-642-35951-4_1003-1
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