References
Blencowe BJ (2006) Alternative splicing: new insights from global analyses. Cell 126:37–47
Bonnal S, Martinez C, Forch P, Bachi A, Wilm M, Valcarcel J (2008) RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. Mol Cell 32:81–95
Cavanagh JFW, Palmer IIIAG, Rance M, Skelton NJ (2007) Protein NMR spectroscopy: principles and practice. Academic, London
Corsini L, Bonnal S, Basquin J, Hothorn M, Scheffzek K, Valcarcel J, Sattler M (2007) U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Nat Struct Mol Biol 14:620–629
Gobl C, Madl T, Simon B, Sattler M (2014) NMR approaches for structural analysis of multidomain proteins and complexes in solution. Prog Nucl Magn Reson Spectrosc 80:26–63
Izquierdo JM, Majos N, Bonnal S, Martinez C, Castelo R, Guigo R, Bilbao D, Valcarcel J (2005) Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition. Mol Cell 19:475–484
Leung AK, Nagai K, Li J (2011) Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis. Nature 473:536–539
Lunde BM, Moore C, Varani G (2007) RNA-binding proteins: modular design for efficient function. Nat Rev Mol Cell Biol 8:479–490
Mackereth CD, Sattler M (2012) Dynamics in multi-domain protein recognition of RNA. Curr Opin Struct Biol 22:287–296
Mackereth CD, Simon B, Sattler M (2005) Extending the size of protein-RNA complexes studied by nuclear magnetic resonance spectroscopy. Chembiochem 6:1578–1584
Mackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcarcel J, Sattler M (2011) Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF. Nature 475:408–411
Madl T, Gabel F, Sattler M (2011) NMR and small-angle scattering-based structural analysis of protein complexes in solution. J Struct Biol 173:472–482
Mourao A, Bonnal S, Soni K, Warner L, Bordonne R, Valcarcel J, Sattler M (2016) Structural basis for the recognition of spliceosomal SmN/B/B′ proteins by the RBM5 OCRE domain in splicing regulation. elife 5:e14707
Nilsen TW, Graveley BR (2010) Expansion of the eukaryotic proteome by alternative splicing. Nature 463:457–463
Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL et al (2005) Structure of PTB bound to RNA: specific binding and implications for splicing regulation. Science 309:2054–2057
Tripsianes K, Madl T, Machyna M, Fessas D, Englbrecht C, Fischer U, Neugebauer KM, Sattler M (2011) Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins. Nat Struct Mol Biol 18:1414–1420
Velazquez-Campoy A, Ohtaka H, Nezami A, Muzammil S, Freire E (2004) Isothermal titration calorimetry. Curr Protoc Cell Biol, Chapter 17: Unit 17 18
Voith von Voithenberg L, Sanchez-Rico C, Kang HS, Madl T, Zanier K, Barth A, Warner LR, Sattler M, Lamb DC (2016) Recognition of the 3′ splice site RNA by the U2AF heterodimer involves a dynamic population shift. Proc Natl Acad Sci USA 113:E7169–E7175
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Mourão, A., Sattler, M. (2019). Alternative Splicing Regulation: Structural and Biophysical Studies. In: Roberts, G., Watts, A. (eds) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35943-9_446-1
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DOI: https://doi.org/10.1007/978-3-642-35943-9_446-1
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