Nucleobase-Ascorbate-Transporter (NAT) Family
Living reference work entry
The NAT/NCS2 family, designated A.2.40 (Saier et al. 2006, 2009), consists of thousands of proteins identified in all major domains of life, from archaea and bacteria to plants and animals (Pantazopoulou and Diallinas 2007; Diallinas and Gournas 2008; Gournas et al. 2008; Frillingos 2012). Prominent evolutionary gene-losses of NATs have been identified in several yeasts, including Saccharomyces cerevisiae, and in major pathogenic protozoa (e.g., Leishmania, Trypanosoma, or Plasmodium). The proteins of the NAT family are 414–650 amino acid residues in length and possess 14 transmembrane mostly α-helical segments (TMHs) characterized by a 7-helix inverted repeat (see later). Eukaryotic NAT members have extended N- and C-terminal cytoplasmic regions that include cis-acting amino acid sequence motifs controlling their traffic to the plasma membrane, as well as their turnover by constitutive or physiologically or...
- Yamamoto S, Inoue K, Murata T, Kamigaso S, Yasujima T, Maeda JY, Yuasa H (2010) Identification and functional characterization of the first nucleobase transporter in mammals: implication in the species difference in the intestinal absorption mechanism of nucleobases and their analogs between higher primates and other mammals. J Biol Chem 285:6522–6531CrossRefPubMedGoogle Scholar
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