Encyclopedia of Biophysics

Living Edition
| Editors: Gordon Roberts, Anthony Watts, European Biophysical Societies

Antibody Modeling, Engineering, and Design

  • Sharon Fischman
  • Yanay Ofran
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-35943-9_10083-1

Introduction

Antibodies, which are primary components of adaptive immunity, are responsible for the body’s recognition of foreign material and subsequent elicitation of immune response to clear these substances. The specific determinant on the antigen that is recognized and bound by the antibody is called the epitope. The region of the antibody that binds the epitope is called the paratope. The immune system can generate a specific binder for virtually any molecular structure by reshuffling and mutating a set of genes that encodes fragments of the antibody. These genes are known as V, D, and J. Over the last few decades, antibodies have become a major reagent in biotechnology and biomedical research and the fastest growing type of therapeutics (Carter and Lazar 2017; Ecker et al. 2015). The fact that antibodies can bind almost any structure is related to the nature of the antibody three-dimensional structure. While there are several classes, also known as isotypes, of antibodies in...
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Copyright information

© European Biophysical Societies’ Association (EBSA) 2018

Authors and Affiliations

  1. 1.Biolojic Design, Ltd.Givat ShmuelIsrael
  2. 2.The Goodman Faculty of Life SciencesBar Ilan UniversityRamat GanIsrael

Section editors and affiliations

  • Franca Fraternali

There are no affiliations available