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Introduction
Melibiose permease (MelB) is encoded by the melB gene in the melAB operon, which is present in many Gram-negative bacteria. MelB belongs to the glycoside–pentoside–hexuronide:cation symporter (GPH) family (TC 2.A.2) of the major facilitator superfamily (MFS). MelB catalyzes the transport of di- or trisaccharides containing a d-galactopyranosyl ring or galactose, and the native substrate is melibiose, a disaccharide formed by an α-1,6 linkage between galactose and glucose (d-Gal-α(1 → 6)-d-Glc) (Fig. 1). It can be also formed by invertase-mediated hydrolysis of raffinose, which produces one melibiose and one fructose.
Structure of melibiose (d-galactopyranosyl-α (1 → 6)-d-glucose). Carbon positions are labeled in red, and the anomeric form of the glycosidic linkage is labeled in blue
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References
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Guan, L. (2018). Na+/Melibiose Membrane Transport Protein, MelB. In: Roberts, G., Watts, A. (eds) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35943-9_10082-1
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DOI: https://doi.org/10.1007/978-3-642-35943-9_10082-1
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