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Nervous About Developments in Electron Transfer-Reactive Oxygen Species-Oxidative Stress Mechanisms of Neurotoxicity?

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Systems Biology of Free Radicals and Antioxidants

Abstract

A broad overview of neurotoxins is presented based on electron transfer, reactive oxygen species, and oxidative stress. Although their mode of action is complex, these aspects evidently play an important role in many cases. It is relevant that metabolites from toxins generally possess electron transfer functionalities, which can participate in redox cycling. Much evidence exists in support of the theoretical framework. Toxic effects at the molecular level include lipid peroxidation, DNA attack, adduction, enzyme inhibition, oxidative attack on the CNS, and cell signaling. The toxins fall into many categories, including drugs, industrial chemicals, abused drugs, reproductive toxins, metal compounds, pesticides, and herbicides. Beneficial effects of antioxidants are documented, which may prove clinically useful. Knowledge of mechanisms operating in CNS insults should prove useful in drug design. This review focusses on recent developments on electron transfer mechanisms in neurotoxicity.

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Acknowledgments

Editorial assistance by Thelma Chavez is acknowledged.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA, 92182, USA

    Peter Kovacic

  2. Centro de Graduados e Investigación del Instituto Tecnológico de Tijuana, Apdo postal 1166, Tijuana, BC, Mexico

    Ratnasamy Somanathan

Authors
  1. Peter Kovacic
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  2. Ratnasamy Somanathan
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Correspondence to Peter Kovacic .

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Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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Kovacic, P., Somanathan, R. (2014). Nervous About Developments in Electron Transfer-Reactive Oxygen Species-Oxidative Stress Mechanisms of Neurotoxicity?. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_90

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