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Effects of Reactive Oxygen Species on Sarco-/Endoplasmic Reticulum Ca2+ Pump in Pig Coronary Artery

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Systems Biology of Free Radicals and Antioxidants

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Abstract

Reactive oxygen species are intermediates in biochemical reactions which are essential for life. However, different types of reactive oxygen species accumulate in excessive amounts during ischemia–reperfusion and can cause tissue damage. In healthy coronary arteries, Ca2+ sequestered in the sarco-/endoplasmic reticulum (SER) by the SER Ca2+ pump (SERCA) plays a pivotal role in signal transduction. SERCA is readily damaged by high levels of reactive oxygen species accumulated in ischemic–reperfused coronary arteries leading to loss of arterial pliability. This chapter gives background on reactive oxygen species and their effects on SERCA and coronary artery contractility and also outlines the unresolved problems in this area.

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Abbreviations

Ang II:

Angiotensin II

Ca2+i:

Cytosolic [Ca2+]

ET:

Endothelin

IP3 :

Inositol 1,4,5-trisphosphate

NCX:

Na+-Ca2+-exchanger

PM:

Plasma membrane

ROS:

Reactive oxygen species

SER:

Sarco-/endoplasmic reticulum

SERCA:

SER Ca2+ pump

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Acknowledgments

This work was supported by a Grant-in-Aid from the Heart & Stroke Foundation of Ontario.

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Authors and Affiliations

  1. Department of Medicine, HSC 4N41, McMaster University, 1200 Main Street West, Hamilton, ON, Canada

    Ashok K. Grover

  2. Department of Biology, HSC 4N41, McMaster University, 1200 Main Street West, Hamilton, ON, Canada

    Jyoti Pande & Ashok K. Grover

Authors
  1. Jyoti Pande
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  2. Ashok K. Grover
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Corresponding author

Correspondence to Ashok K. Grover .

Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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Pande, J., Grover, A.K. (2014). Effects of Reactive Oxygen Species on Sarco-/Endoplasmic Reticulum Ca2+ Pump in Pig Coronary Artery. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_51

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