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Bioadhesives: Chemistry and Mode of Operation

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Encyclopedia of Polymeric Nanomaterials

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Synonyms

Bioadhesion; Mucoadhesion

Definitions

Bioadhesion: A state in which two materials, at least one of which of biological origin, are held together by interfacial forces for extended periods of time [1].

Mucoadhesion: A special case of bioadhesion, where polymer chains penetrate mucosa interfaces and subsequently adhere to the mucosa [2, 3].

Introduction to Bioadhesive Applications

The following three fields have been identified as main areas for the use of bioadhesives:

Pharmaceutical Sciences for Drug Delivery

Bioadhesives have been developed for the delivery of small organic molecules, antibiotics, proteins, vaccines, and DNA via the mucosa in the following delivery routes: buccal, oral, nasal, ocular, rectal, vaginal, and transdermal. The mucosa is the moist surface lining of the walls of various body cavities; it is covered with mucus, a viscoelastic hydrogel. Hydrophilic macromolecules with the ability of forming hydrogen bonds act as mucoadhesives materials. Mucoadhesion...

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Author information

Authors and Affiliations

  1. Department of Chemistry, University of Alabama in Huntsville, 301 Sparkman Drive, Huntsville, AL, 35899, USA

    David Ulkoski & Carmen Scholz

Authors
  1. David Ulkoski
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  2. Carmen Scholz
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Corresponding author

Correspondence to David Ulkoski .

Editor information

Editors and Affiliations

  1. Center for Fiber and Textile Science, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, Japan

    Shiro Kobayashi

  2. Max Planck Institute for Polymer Research, Mainz, Germany

    Klaus Müllen

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Ulkoski, D., Scholz, C. (2015). Bioadhesives: Chemistry and Mode of Operation. In: Kobayashi, S., Müllen, K. (eds) Encyclopedia of Polymeric Nanomaterials. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29648-2_281

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