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Dye, Photodynamic Therapy

Encyclopedia of Color Science and Technology

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Definition

Photodynamic therapy may be thought of as a directed and controlled application of the cellular damage possible from light energy. There are two main areas of clinical interest, these being the photodynamic therapy of cancer (shortened to PDT) and the parallel application to microbial disease and infection control, the latter having several names, including antimicrobial photodynamic therapy (APDT), photodynamic antimicrobial chemotherapy (PACT, used in this review), and photodynamic disinfection (PDD). In the case of both areas clinical interest, in order to target and mediate cellular damage, a light-absorbing chemical, called a photosensitizer, is used.

In both anticancer and antimicrobial guises, the underlying science is the same, namely, (i) uptake by or association of the target cell with a photosensitizer, (ii) illumination of the target cell and the concomitant electronic excitation of the photosensitizer, and (iii) chemical reaction of the photosensitizer with its...

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References

  1. Brown, S.B., Brown, E.A., Walker, I.: The present and future role of photodynamic therapy in cancer treatment. Lancet Oncol. 5, 497–508 (2004)

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  2. Wainwright, M.: Photodynamic antimicrobial chemotherapy (PACT). J. Antimicrob. Chemother. 42, 13–28 (1998)

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Authors and Affiliations

  1. Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF, UK

    Mark Wainwright

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  1. Mark Wainwright
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Correspondence to Mark Wainwright .

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  1. School of Design University of Leeds, Leeds, United Kingdom

    Ronnier Luo

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© 2013 Springer Science+Business Media New York

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Wainwright, M. (2013). Dye, Photodynamic Therapy. In: Luo, R. (eds) Encyclopedia of Color Science and Technology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27851-8_160-1

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  • DOI: https://doi.org/10.1007/978-3-642-27851-8_160-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27851-8

  • eBook Packages: Springer Reference Physics and AstronomyReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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Chapter history

  1. Latest

    Dye: Photodynamic Therapy
    Published:
    12 January 2021

    DOI: https://doi.org/10.1007/978-3-642-27851-8_160-2

  2. Original

    Dye, Photodynamic Therapy
    Published:
    29 September 2014

    DOI: https://doi.org/10.1007/978-3-642-27851-8_160-1

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