Definition
Acute myeloid leukemia (AML) is part of a group of hematological malignancies (Hematological Malignancies, Leukemias and Lymphomas) in the bone marrow involving cells committed to the myeloid line of cellular development. It is defined by the malignant transformation of a bone marrow-derived, self-renewing stem cell or progenitor which demonstrates a decreased rate of self-destruction and aberrant differentiation. Uncontrolled growth of such cells, named blasts, is the result of clonal proliferation. Blasts accumulate in the bone marrow and other organs. As a result, mature cells of hematopoiesis are suppressed. For the leukemia to be called acute, the bone marrow must include greater than 20 % leukemic blasts.
Characteristics
Classification
The first comprehensive morphologic-histochemical classification system for AML was developed by the French-American-British (FAB)...
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References
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See Also
(2012) Clonal Proliferation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 884. doi:10.1007/978-3-642-16483-5_1220
(2012) Comorbidity. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 960. doi:10.1007/978-3-642-16483-5_1280
(2012) Cytogenetic Analysis. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1050. doi:10.1007/978-3-642-16483-5_1468
(2012) Differentiation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1113. doi:10.1007/978-3-642-16483-5_1616
(2012) Hematopoiesis. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1644. doi:10.1007/978-3-642-16483-5_2616
(2012) Myeloid. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2436. doi:10.1007/978-3-642-16483-5_3935
(2012) Petechiae. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2829. doi:10.1007/978-3-642-16483-5_4481
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Deschler, B. (2014). Acute Myeloid Leukemia. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_60-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_60-2
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